Palancade lab
@palancadelab.bsky.social
Benoit Palancade's lab at Institut Jacques Monod - part of @cnrs.fr and @upcite.bsky.social. Exploring the mysterious connexions between mRNA metabolism and genome functions - DNA:RNA hybrids, genome stability, gene expression, RNA regulons, RBPomes
Read more here: rdcu.be/ecYmz (8/8)
DNA lesions can frequently precede DNA:RNA hybrid accumulation
Nature Communications - DNA:RNA hybrids are linked to genetic instability in several pathological situations. Here, the authors report that various types of DNA lesions can trigger hybrid formation...
rdcu.be
March 11, 2025 at 4:42 PM
Read more here: rdcu.be/ecYmz (8/8)
Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)
March 11, 2025 at 4:42 PM
Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)
Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)
March 11, 2025 at 4:42 PM
Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)
Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)
March 11, 2025 at 4:42 PM
Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)
For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)
March 11, 2025 at 4:42 PM
For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)
We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)
March 11, 2025 at 4:42 PM
We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)
In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)
March 11, 2025 at 4:42 PM
In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)