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Tim Cleland @paleoproteomicist.bsky.social · 21d

We characterized the membranes after demineralization from pieces of shell from the edge of the opening.

Ecphora gardnerae shells from the paper. Each gastropod (snail) shell has external ridges and they all have a rust orange coloration.

Tim Cleland @paleoproteomicist.bsky.social · 21d

Like other invert paleoproteomic studies, we were hindered by limited protein annotations. This study required conversion of several Conus genomes to protein databases with GeMoMa to have searchable gastropod databases.

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Tim Cleland @paleoproteomicist.bsky.social · 21d

As part of the study we also explored the mineral preservation with both scanning electron microscopy and Raman spectroscopy. We found that the membranes come from the calcite crust layer of the shells.

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Tim Cleland @paleoproteomicist.bsky.social · 21d

#palaeoproteomics

Tim Cleland @paleoproteomicist.bsky.social · 21d

I have a new paper with @iondoctor.bsky.social and other MCI, Carnegie Science, and Calvert Marine Museum colleagues where we analyzed 8 and 10 million year old Ecphora shell membranes. We found chitin and various gastropod specific peptides. www.app.pan.pl/article/item...

Protein and chitin preservation in polymeric sheets in Miocene <em>Ecphora gardnerae</em> shells from Maryland, USA - Acta Palaeontologica Polonica

www.app.pan.pl

Tim Cleland @paleoproteomicist.bsky.social · 21d

We detected the chitin with DART-MS not requiring addition sample preparation beyond isolating the membranes from the mineral matrix. To our knowledge, this is the oldest chitin detected by DART-MS.

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Tim Cleland @paleoproteomicist.bsky.social · 21d

I have a new paper with @iondoctor.bsky.social and other MCI, Carnegie Science, and Calvert Marine Museum colleagues where we analyzed 8 and 10 million year old Ecphora shell membranes. We found chitin and various gastropod specific peptides. www.app.pan.pl/article/item...

Protein and chitin preservation in polymeric sheets in Miocene <em>Ecphora gardnerae</em> shells from Maryland, USA - Acta Palaeontologica Polonica

www.app.pan.pl

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Reposted by Tim Cleland

asher newsome @iondoctor.bsky.social · Aug 18

My second paper with former fellow Tjasa is out now. The focus is about swabbing large plastic art objects to study their surfaces (so that anyone can do it for GCMS) but we also do NPDPI for real-time high-res MS www.nature.com/articles/s40...

Non-destructive mass spectrometry of historical poly(vinyl chloride) object surfaces with swab analysis - npj Heritage Science

npj Heritage Science - Non-destructive mass spectrometry of historical poly(vinyl chloride) object surfaces with swab analysis

www.nature.com

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Tim Cleland @paleoproteomicist.bsky.social · Jul 17

www.cambridge.org/core/journal...

On the impact of micro-CT scanning on radiocarbon dating of fossil material: A cautionary note for the palaeoanthropological community and beyond | Radiocarbon | Cambridge Core

On the impact of micro-CT scanning on radiocarbon dating of fossil material: A cautionary note for the palaeoanthropological community and beyond

www.cambridge.org

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Tim Cleland @paleoproteomicist.bsky.social · Jul 17

The impacts of microCT on preserved proteins is something we probably need to consider in the #palaeoproteomics community as well. theconversation.com/scientists-c...

Scientists could be accidentally damaging fossils with a method we thought was safe

A common scanning method used to create ‘virtual copies’ of precious fossils could be erasing some of the crucial information held within.

theconversation.com

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Reposted by Tim Cleland

Tim Cleland @paleoproteomicist.bsky.social · Jul 9

We published a new paper on enamel paleoproteomics from teeth up to 18 million years old from the Turkana Basin in Kenya. www.nature.com/articles/s41...

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

www.nature.com

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Reposted by Tim Cleland

Kevin Uno @kevinuno.bsky.social · Jul 9

Check out our new paper, led by former postdoc and current colleague Daniel Green on 18 Ma proteins in fossil teeth! Tim Cleland, a proteomics wizard, did the measurements. What's the take home? We hope to use protein fingerprints to study mammal and hominin phylogenetics! bit.ly/OldProteome

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

bit.ly

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Reposted by Tim Cleland

Frido Welker @fridowelker.bsky.social · Jul 9

Two great new studies out in @nature.com today, pushing back the recovery of dental enamel proteins to 21+ million years in the Arctic (www.nature.com/articles/s41...) and 18+ million years in East Africa (www.nature.com/articles/s41...).

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

www.nature.com

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Reposted by Tim Cleland

Riley Black 🦕 🏳️‍⚧️ @restingdinoface.bsky.social · Jul 9

Are we ever going to say “Bingo! Dino DNA”? No. But there are other microbio clues about ancient creatures in the rock record, including proteins from 18 million years ago that may help work our relationships of extinct creatures. And it hints there are likely even older protein scraps out there.

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

www.nature.com

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Reposted by Tim Cleland

Nature @nature.com · Jul 9

Molecules from 20-million-year-old rhino-relative teeth are among the oldest ever sequenced

go.nature.com/4lFx4KN

Ancient proteins rewrite the rhino family tree — are dinosaurs next?

Molecules from 20-million-year-old teeth are among the oldest ever sequenced.

go.nature.com

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Reposted by Tim Cleland

Meagan Mulcair, Ph.D. @drmeagan.bsky.social · Jul 9

The record for the oldest protein ever found has been smashed five-fold after analyzing ancient fossilized teeth 🦷

@paleoproteomicist.bsky.social @fridowelker.bsky.social @harvardpress.bsky.social @smithsonianmag.bsky.social @newscientist.com

www.newscientist.com/article/2487...

Oldest proteins yet recovered from 18-million-year-old teeth

The oldest protein fragments ever recovered have been extracted from fossilised teeth found in Kenya's Rift Valley, revealing the remains belonged to the ancient ancestors of rhinoceroses and elephant...

www.newscientist.com

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Tim Cleland @paleoproteomicist.bsky.social · Jul 9

We explored teeth ranging in age from 1.5 million years to 29 million years from a variety of species including elephant relatives, rhino relatives, and hippo relatives.

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Tim Cleland @paleoproteomicist.bsky.social · Jul 9

This is a super exciting day for paleoproteomics. In addition to our paper on Kenyan enamel, the Cappellini group published a complementary paper on 21-24 million year old enamel from the Arctic www.nature.com/articles/s41...

Phylogenetically informative proteins from an Early Miocene rhinocerotid - Nature

Protein sequences from fossil tooth enamel of a rhinocerotid from Canada’s High Arctic are used to develop phylogenetic frameworks from a specimen too old to preserve ancient DNA.

www.nature.com

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Tim Cleland @paleoproteomicist.bsky.social · Jul 9

We published a new paper on enamel paleoproteomics from teeth up to 18 million years old from the Turkana Basin in Kenya. www.nature.com/articles/s41...

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

www.nature.com

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Tim Cleland @paleoproteomicist.bsky.social · Jun 20

Mary was a good advisor but always had struggles throughout her career both before the 2005 soft tissue paper and significantly after.

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Tim Cleland @paleoproteomicist.bsky.social · Jun 20

🤔

Tim Cleland @paleoproteomicist.bsky.social · Jun 7

If you’d like me to do a GeMoMa conversion and send it to you let me know which caiman genome you’d like converted and I can email the proteome to you.

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Tim Cleland @paleoproteomicist.bsky.social · Jun 1

@iondoctor.bsky.social and I will be presenting our museum work at #ASMS2025

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Tim Cleland @paleoproteomicist.bsky.social · May 14

I was recently asked to do so on a non-model organism project and I suggested my coauthors say that the proteomics community does not support using Westerns this way and gave them the following pubs: www.nature.com/articles/s41... and www.mcponline.org/article/S153...

The incongruity of validating quantitative proteomics using western blots - Nature Plants

Nature Plants - The incongruity of validating quantitative proteomics using western blots

www.nature.com

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Reposted by Tim Cleland

Welker Group @welkergroup.bsky.social · Apr 24

New publication! 🎉 Here you can read all about dog drool, bleach, and a probable Central Asian Neanderthal child:
doi.org/10.1016/j.ja...

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Reposted by Tim Cleland

Matthew Collins @matthewcollins.bsky.social · Jan 21

10th Bone Diagenesis Meeting, to be held in Athens, Greece 🇬🇷, on 24–26 September 2025

American School of Classical Studies at Athens (ASCSA)

bd-2025.com

Abstract submission is now open!

more information here: bd-2025.com/abstracts

10th International Bone Diagenesis Meeting

It is with great pleasure that we invite you to the 10th Bone Diagenesis Meeting, to be held in Athens, Greece on 24-26 September 2025. Our meeting will take place at the premises of the American Scho...

bd-2025.com

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