Pengxin Chai
@pengxinchai.bsky.social
40 followers 71 following 3 posts
Graduate student in Kai Zhang Lab at Yale MB&B.
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pengxinchai.bsky.social
Thrilled to receive this special gift from the Kai Zhang lab—a 3D-printed model of Dynein-X—to celebrate my graduation! Huge thanks to my advisor, Kai, for the support and mentorship. This model is definitely going on my desk!
pengxinchai.bsky.social
Thrilled to receive this special gift from the Kai Zhang lab—a 3D-printed model of Dynein-X—to celebrate my graduation! Huge thanks to my advisor, Kai, for the support and mentorship. This model is definitely going on my desk!
pengxinchai.bsky.social
This DHC is non-motile and forms a heterodimeric "phi particle" with another, yet-to-be-identified axonemal DHC, potentially playing a role in axonemal dynein inhibition and transport. This discovery sheds light on a previously unexplored area of "dynein diversity" and opens future directions.
pengxinchai.bsky.social
Excited to share our work on bioRxiv before my thesis defense! Together with my undergraduate mentee Diego, postdocs Wan and Jun, and my advisor Kai, we identified a novel dynein heavy chain subfamily, DNAHX, from sea urchin sperm axoneme.

Check out the details here: www.biorxiv.org/content/10.1...
DNAHX: a novel, non-motile dynein heavy chain subfamily, identified by cryo-EM endogenously
Ciliogenesis and cilia motility rely on the coordinated actions of diverse dyneins, yet the complexity of these motor proteins in cilia has posed challenges for understanding their specific roles. Tra...
www.biorxiv.org