@PhysGenCenter
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The mission of the Center for Physical Genomics and Engineering at Northwestern University’s McCormick School of Engineering is to create new strategies for the treatment of disease and the reversible manipulation of living systems
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@PhysGenCenter
@physgencenter.bsky.social
· Jul 14
Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome - Nature Communications
Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promotin...
www.nature.com
@PhysGenCenter
@physgencenter.bsky.social
· Jul 10
Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing
In single cells, chromatin packs into organized structures to perform biological functions, such as RNA transcription regulation. Characterizing such structural behaviors, including packing density an...
pubs.acs.org
Reposted by @PhysGenCenter
Luay Almassalha
@almassalha.bsky.social
· May 30
Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome
Human tissues require a mechanism to generate durable, yet modifiable, transcriptional memories to sustain cell function across a lifetime. Previously, we demonstrated that nanoscale packing domains c...
www.biorxiv.org
Reposted by @PhysGenCenter