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pina85.bsky.social
Giuseppina lambiase
@pina85.bsky.social
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Giuseppina lambiase @pina85.bsky.social · May 2
I'm thrilled to announce that my #phd work is now out in #biorxiv. Check it out here! I will be happy to have your feedback! www.biorxiv.org/content/10.1... Thank you to @karinayaniv.bsky.social, Rudra N. Das for the menthorship and all authors.
In this work we discovered that during metamophosis there is a remodeling of Zebrafish Cardinal Vein followed by a replacement with the Inferior Vena Cava. This process mirrors the Human Inferior Vena Cava development, demostrating a conserved mechanism through the mammals. In this panel all the steps of Inferior Vena Cava formation (blood vascular marker, kdrl in green).
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Giuseppina lambiase @pina85.bsky.social · May 3
Thank you very much for the support !
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Giuseppina lambiase @pina85.bsky.social · May 2
Thank you Laura!
pina85.bsky.social
Giuseppina lambiase @pina85.bsky.social · May 2
Functionally, we demostrated that transition from CV to IVC represents a shift from a multifunctional embryonic vein to a specialized adult conduit adapted for high-volume blood return.
Here one of the functional divergence between CV and IVC. Rhodamine Dextran 10KDA is internalized by the embryonic cardinal vein ( fig. I, yellow arrowheads) but not by the IVC (fig.J) indicating that IVC lack the scavenger function characteristic of their CV counterparts!
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pina85.bsky.social
Giuseppina lambiase @pina85.bsky.social · May 2
We found that this vein-to-vein process is regulated by vegfa/flt1/dll4 axis.
This panel shows a malformed IVC when vegfa is mutated
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pina85.bsky.social
Giuseppina lambiase @pina85.bsky.social · May 2
Using lineare tracing tool we demostrated that IVC arise only from the venous source with no contribution of the #Artery or #lymphatic
In this panel, “flibow” tool was used to study the cellular original of the inferior Vena Cava. Venous sprouts from the cardinal vein ( fig. D, magenta arrowhead) give rise to the Inferior Vena Cava (fig. F, magenta arrowhead) .
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pina85.bsky.social
Giuseppina lambiase @pina85.bsky.social · May 2
I'm thrilled to announce that my #phd work is now out in #biorxiv. Check it out here! I will be happy to have your feedback! www.biorxiv.org/content/10.1... Thank you to @karinayaniv.bsky.social, Rudra N. Das for the menthorship and all authors.
In this work we discovered that during metamophosis there is a remodeling of Zebrafish Cardinal Vein followed by a replacement with the Inferior Vena Cava. This process mirrors the Human Inferior Vena Cava development, demostrating a conserved mechanism through the mammals. In this panel all the steps of Inferior Vena Cava formation (blood vascular marker, kdrl in green).
1 4 19