banner
planarian-brain.bsky.social
INOUE, Takeshi
@planarian-brain.bsky.social
39 followers 54 following 31 posts
プラナリア、脳、定量行動学、環境応答行動、環境適応、再生 /Planarian, Brain, Quantitative Ethology, Environmental response behavior, Environmental Adaptation, and Regeneration https://www.planarianbrain.com
www.planarianbrain.com
Posts Media Videos Starter Packs
Pinned
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Nov 27
Our latest paper entitled "Quantification of planarian behaviors" is published online @dgd_journal. This protocol paper is useful for spatio-temporal analyses of not just planarian behaviors but also for other organisms and cells. #planarian #プラナリア

onlinelibrary.wiley.com/doi/10.1111/...
Quantification of planarian behaviors
Spatiotemporal measurement of individual behaviors offers opportunities to understand complex neural machinery and regeneration of the nervous system in planarians. We describe our step-by-step proto...
onlinelibrary.wiley.com
3
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · 14d
Paper out! Collaborative decoding of the Iberian ribbed newt genome in iScience

The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians: iScience

www.cell.com/iscience/ful...
The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians
Zoology; Phylogenetics; Evolutionary biology; Phylogeny
www.cell.com
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · 20d
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense
Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells -- T cells, natural killer cells, and neutrophils. Here, we identify 'ruptoblasts', a previously unknown cytotoxic ...
www.biorxiv.org
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Sep 2
SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians | bioRxiv
www.biorxiv.org/content/10.1...
SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians
Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying how stem cell fates are specified as neurons in an adul...
www.biorxiv.org
1 4
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Aug 23
Genetic and Genomic Insights into Planarian Biology | Annual Reviews
www.annualreviews.org/content/jour...
Genetic and Genomic Insights into Planarian Biology | Annual Reviews
Species such as planarians expand our horizons of imagination and fuel innovation. The ability to regenerate any tissues lost to injury has fascinated many generations of biologists studying regenerat...
www.annualreviews.org
1 1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Aug 11
Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl - Hayashi - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....
Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl
Cell tracing is an essential method for deciphering cellular processes during organ regeneration. We generated transgenic Iberian ribbed newts carrying the multicolor reporter Brainbow3.0 cassette un...
onlinelibrary.wiley.com
1 1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jun 19
「プラナリアの体が宿した"記憶"」
少しだけコメントさせていただきました。
www.nikkei-science.com/page/magazin...
2025年8月号｜日経サイエンス
天体物理学 特集：認知の原点を探る 人工知能がこれだけ発展しても，私たちはまだ自らの知能についてよく理解できていない。プラナリアの脳再生や動植物の賢い振る舞い，AIとロボットの関係など多様な視点から生物の認知機能を見つめ … 続きを読む →
www.nikkei-science.com
1 2 3
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jun 14
Step‐by‐Step Protocol for Making a Knock‐In Xenopus laevis to Visualize Endogenous Gene Expression - Kagawa - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jun 11
our paper is out!

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs - ScienceDirect
www.sciencedirect.com/science/arti...
Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs
Previous studies suggested the importance of the reciprocal interactions between residual tissues, which we refer to here as the “stump”, and the newl…
www.sciencedirect.com
1 2
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jun 6
Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea | bioRxiv
www.biorxiv.org/content/10.1...
Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea
N6-methyladenosine (m6A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules. This post-transcriptional modification is essential in biological contexts ranging...
www.biorxiv.org
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · May 29
A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen | BMC Genomics
bmcgenomics.biomedcentral.com/articles/10....
A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen - BMC Genomics
Background The isolation of intact, high-molecular-weight genomic DNA (HMW gDNA) is essential for achieving complete genome assemblies. However, extracting HMW gDNA from a single individual of Dugesia...
bmcgenomics.biomedcentral.com
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · May 26
Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons | bioRxiv
www.biorxiv.org/content/10.1...
Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons
During regenerative neurogenesis, neurons must be created in the right types and locations. Though regenerative neurogenesis is limited in humans, other animals use regenerative neurogenesis to faithf...
www.biorxiv.org
2
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · May 16
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians | bioRxiv
www.biorxiv.org/content/10.1...
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians
POU4 homologs are involved in the development of sensory cell types across diverse species, including cnidarians, ascidians, and mammals. Whether these developmental regulators are reused during adult...
www.biorxiv.org
2
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Apr 21
Frontiers | Planarian RNAi knockdown: feeding once might just be enough
www.frontiersin.orghttps//www.frontie...
www.frontiersin.orghttps
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Apr 18
Developmental onset of planarian whole-body regeneration depends on axis reset: Current Biology
www.cell.com/current-biol...
Developmental onset of planarian whole-body regeneration depends on axis reset
Booth et al. show that the planarian Schmidtea polychroa gradually gains its impressive regenerative abilities during development. While regeneration involves many factors, this study shows that the r...
www.cell.com
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Apr 16
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - 2025 - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants
Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro...
onlinelibrary.wiley.com
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Apr 4
Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging
www.nature.com/articles/s43...
Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging
The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...
www.nature.com
2 6
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Apr 2
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense
Cytotoxic killing is an essential immune function, yet its cellular mechanisms have been characterized in only a few model species. Here, we show that planarian flatworms harness a unique cytotoxic st...
www.biorxiv.org
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Mar 30
Temporal integration and active sensing of light in planarians | bioRxiv
www.biorxiv.org/content/10.1...
Temporal integration and active sensing of light in planarians
Animal light sensing and processing are intimately connected to the design of the sensory apparatus, with eye-design a subject of longstanding interest. Understanding animal response to stimuli can el...
www.biorxiv.org
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Mar 13
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells | BMC Genomics |
bmcgenomics.biomedcentral.com/articles/10....
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells - BMC Genomics
Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...
bmcgenomics.biomedcentral.com
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Feb 24
Keratinocyte-driven dermal collagen formation in the axolotl skin | Nature Communications
www.nature.com/articles/s41...
Keratinocyte-driven dermal collagen formation in the axolotl skin - Nature Communications
Type I collagen in the dermis is a major component of the skin, though how this collagen is formed and modified as remained unclear. Here they show that keratinocytes contribute to dermal collagen for...
www.nature.com
3 4
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Feb 12
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/abs/10.1...
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants
Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro....
onlinelibrary.wiley.com
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Feb 2
Regeneration in the absence of canonical neoblasts in an early branching flatworm

www.nature.com/articles/s41...
Regeneration in the absence of canonical neoblasts in an early branching flatworm - Nature Communications
Adult pluripotent stem cells, called neoblasts, are considered a defining feature of all flatworms. This manuscript shows that canonical neoblasts are absent in an early branching flatworm lineage, ra...
www.nature.com
2
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jan 29
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration: Cell Genomics
www.cell.com/cell-genomic...
Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration
Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...
www.cell.com
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jan 14
A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient. | bioRxiv
www.biorxiv.org/content/10.1...
A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient.
Planarians exhibit remarkable whole-body regeneration abilities. The formation of heads at forward-facing wounds and tails at rearward-facing wounds suggests an intrinsic tissue polarity guiding regen...
www.biorxiv.org
1
planarian-brain.bsky.social
INOUE, Takeshi @planarian-brain.bsky.social · Jan 10
Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4 - Tozawa - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....
Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4
Studies on Hox13, Fgf10, and Tbx4 mutant newts with hindlimb defects showed a novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4.
onlinelibrary.wiley.com
1 1