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Pieter Meysman

@pmeysman.bsky.social

290 followers 120 following 56 posts

Professor in biomedical data science at the University of Antwerp. Part-time CTO of ImmuneWatch. Immunoinformatics with a focus on T-cell receptors.

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Pieter Meysman @pmeysman.bsky.social · 12d

Very proud to have been a jury member at the newly revived @iscb.bsky.social RSG Belgium hackathon! Exciting to see so many people giving their best efforts tackling challenging #bioinformatics problems!

Pieter Meysman @pmeysman.bsky.social · Jul 21

The AIRR Diagnostics WG commentary is now available, wherein our members discuss both the challenges of current #AIRR-based #diagnostics, as well as the future directions that we see the field going into!
www.sciencedirect.com/science/arti...

Challenges and Future Directions of AIRR-seq-Based Diagnostics

Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a promising diagnostic method across various clinical conditions, yet its widespread impl…

www.sciencedirect.com

Pieter Meysman @pmeysman.bsky.social · May 29

That's it. #ATCR25 is over!
Thanks again to all attendees, speakers and support staff for making this an amazing meeting!

Pieter Meysman @pmeysman.bsky.social · May 28

Last #ATCR25 speaker: Paul Thomas on deciphering the T cell receptor recognition code.

Pieter Meysman @pmeysman.bsky.social · May 28

Fifth speaker on #ATCR25 day 2: Michael Birnbaum on high throughput TCR analysis and generation.

Pieter Meysman @pmeysman.bsky.social · May 28

Fifth speaker, #ATCR25 day 2: Encarnita Mariotti-Ferrandiz on TCR repertoire signatures in auto immune and infectious disease.

Pieter Meysman @pmeysman.bsky.social · May 28

Fourth speaker, #ATCR25 day 2: Hashem Koohy on decoding antigen-specific T cell recognition.

Pieter Meysman @pmeysman.bsky.social · May 28

Third speaker, #ATCR25 day 2, Soumya Raychaudhuri on how the HLA affects the TCR repertoire, and how the TCR affects cell fate.

Pieter Meysman @pmeysman.bsky.social · May 28

MHC peptide predictions are accurate but fail to identify the few immunodominant epitopes within the larger list of binders.

Pieter Meysman @pmeysman.bsky.social · May 28

There many epitopes that could induce a strong T cell response, but do not get processed from their protein and do not get presented.

Pieter Meysman @pmeysman.bsky.social · May 28

Second speaker, #ATCR25 day 2: Antonio Lanzavecchia on CD8 T cell immunodominance

Pieter Meysman @pmeysman.bsky.social · May 28

Immunogenecity might not be the best sole criteria for the basis of vaccines, epitopes need to be protective too. This is hard but doable to figure out.

Pieter Meysman @pmeysman.bsky.social · May 28

Organoids might be a way forward, but not the answer to everything (but could be the answer to a lot of things)

Pieter Meysman @pmeysman.bsky.social · May 28

The spleen harbor a collection of different immune cells, and contain memory of infection and vaccination.

Pieter Meysman @pmeysman.bsky.social · May 28

Next topic: two classes of regulatory T cells: CD4 Foxp3 T cells regulating B cells and a CD8 regulatory subset using granzyme B regulating T cell auto reactivity.

Pieter Meysman @pmeysman.bsky.social · May 28

Exposure to pathogens (Mtb, CMV,...) remodels our immune system in a way that benefits them (and may hurt us)

Pieter Meysman @pmeysman.bsky.social · May 28

Within TCR repertoires are motif clusters linked to disease progression, suggesting the existence of 'distractopes', epitopes that the disease wants you to react to, as a 'smoke screen' to redirect or exhaust the immune system.

Pieter Meysman @pmeysman.bsky.social · May 28

Investigating the way that Mtb evades the immune system lead to the innovation of looking at the TCRs from tetramer sorting experiments.

Pieter Meysman @pmeysman.bsky.social · May 28

Second topic: failures in vaccine trials. An infectious disease only becomes 'famous' when it learns how to evade our immune system.

Pieter Meysman @pmeysman.bsky.social · May 28

First topic: how do human immune systems compare to inbred mice? Mice are the 'starter car', simple but lacking complexity, leading to failure in mice models.

Pieter Meysman @pmeysman.bsky.social · May 28

First speaker, second #ATCR25 day: Mark Davis on analyzing the T cell response.

Pieter Meysman @pmeysman.bsky.social · May 27

#ATCR25 short talk 8: Nicole Mifsud on the immune signatures of alloreactive T cells during transplantation rejection.

Pieter Meysman @pmeysman.bsky.social · May 27

#ATCR25 short talk 7: Vincent Van Deuren on using TRIASSIC to identify convergent TCR clusters in the synovial fluid of rheumatoid arthritis patients.

Pieter Meysman @pmeysman.bsky.social · May 27

#ATCR25 short talk 6: Orian Bricard on using TWISTAR to identify cognate cancer epitopes of a TCR of interest.

Pieter Meysman @pmeysman.bsky.social · May 27

#ATCR25 short talk 5: Giancarlo Croce on using phage display screening to identify cancer-specific TCRs at the epitope level.