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Reposted by Prof Chloe Orkin

hideta77.bsky.social @hideta77.bsky.social · Aug 13

Pleased to inform that a consortium of Japanese doctors has published a paper on LAI. I’m honored to be listed as a co-author. Prof. Orkin encouraged us to form the consortium. We appreciate your support. @profchloeorkin.bsky.social @toshtaniguc.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

Evaluation of cabotegravir plus rilpivirine in routine clinical settings in Japan: A multicentre study of efficacy, safety and biomarker dynamics

Objectives Long-acting cabotegravir plus rilpivirine (CAB+RPV) offers an alternative to daily oral therapy, but real-world data in East Asia remain scarce. This study aims to evaluate the impact of ...

onlinelibrary.wiley.com

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Reposted by Prof Chloe Orkin

UK-CAB @ukcab.bsky.social · Aug 6

We encourage all people living with HIV in Europe to join this short study run by @shareeastlondon.bsky.social & @profchloeorkin.bsky.social to share their experiences with new HIV treatments & conversations with the clinical teams about treatment choices.

Visit the page & complete the survey below

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Prof Chloe Orkin @profchloeorkin.bsky.social · Jul 23

Are you:
✅working in a UK sexual health service that provides #PrEP,
AND
✅willing to take part in a 15 minute survey?
We are conducting a brief survey of sexual health clinics for our #beyondtheclinic study. You can complete the survey here: bit.ly/40weNaX #studyparticipants

Beyond the Clinic Survey | SHARE Research Collaborative

A survey to understand the breadth and scale of issues which may impact equitable implementation of CAB-LA outside of sexual health clinics in the UK.

bit.ly

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Reposted by Prof Chloe Orkin

Matthew Hodson @matthewhodson.bsky.social · Jul 22

Do you live with HIV?
Are you in Europe and currently on treatment?
Please take part in the Ask Us Europe survey, which aims to improve treatment and care for people with HIV.
I am proud to have worked on it with @shareeastlondon.bsky.social and a powerful group of people with HIV.
Please share. 🙏

Flyer for the Ask Us Europe study, including a QR code. I will add the link to the survey in a post that I will thread to this one.

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Prof Chloe Orkin @profchloeorkin.bsky.social · Jul 22

Our latest study to understand the perspective of people living with HIV in Europe is now live!

We created it together with an amazing steering group of community members from 17 countries.

Please do the survey if you are living with HIV in UK and Europe and SHARE widely !! 🙏🙏🙏🙏

SHARE Collaborative @shareeastlondon.bsky.social · Jul 22

Our latest study 'ASK US Europe' is live and open to recruitment for people living with HIV in Europe who are on ART!

Please share widely across your networks in Europe and the UK.

bit.ly/4m5ktRm

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Ask Us Europe

This survey aims to gather insights from the perspective of people living with HIV on discussions with HIV healthcare provider about new HIV treatments.

bit.ly

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Reposted by Prof Chloe Orkin

WHO @who.int · Mar 27

A decline in funding for the HIV response could result in millions of preventable new infections and deaths, with up to 120,000 of these deaths affecting children.

International cooperation is essential to sustain the advances we’ve made in HIV prevention, testing, and treatment.

bit.ly/43uTfxA

10 million potential new HIV infections by 2030; 3 million potential more deaths, including 120,000 children, due to HIV-related causes by 2030. This could be the impact of HIV funding cuts.

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Reposted by Prof Chloe Orkin

BK. Titanji @boghuma.bsky.social · Mar 24

🚨1.25 million people died of TB in 2023
🚨10.8 million new cases of TB were diagnosed in 2023
🚨Multi-drug resistant TB is a public health crisis
🚨US$ 22 billion is needed annually for TB prevention, diagnosis, treatment and care, but funding is being cut.
🚨Poverty fuels TB globally
#WorldTBDay2025

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 20

#DEI , women’s rights, LGBTQ+ rights, disability rights, global & domestic public health are under attack and being censored in the US.

Let’s remember the phenomenon of ‘social contagion’ -the concept that thoughts 💭 can be as contagious as viruses 🦠 and keep committing to celebrating #DEI 🏳️‍🌈🏳️‍⚧️✊🏿♿️

Photo of woman with purple hair and rainbow t shirt.
Text reads : Queen Mary
University of London
Celebrating Women's History
Month
'Stories of everyday sexism and sexual harassment appear almost daily in the news because sexism and harassment continue to be perpetrated in the workplace with depressing frequency.
That's why celebrating women who speak up and beat a better path for those who follow them continues to be relevant.'

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 20

Nice to see your lovely photos again

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 12

Re-suppression post CAB LA PrEP 083 #CROI2025
9/44 had INSTI resistance before ART

6/6 people suppressed on INSTIs (VL less than / equal to 50 c/ML)

15/16 on other ART

5 further participants from other oral regimens switched to INSTIs afterwards and maintained suppression where data available.

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 12

Very strong data from the PILLAR study LA CAB PrEP #CROI2025 60% were cis BiPOC men and were 6% trans men

•201 people
•0 transmissions
•High retention and coverage
•22% had not taken PrEP in past 3/12

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 12

Brazilian CAB PrEP cohort #CROI2025
•genXpert test at baseline
•diverse cohort
•86% chose CAB LA
•CAB adherence very high
•PREP coverage much higher than oral PrEP
•no incident infections on CAB
•6% did not persist on CAB
• 4% switched away due to side effects

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 12

Very strong data on LA CAB PrEP from Kaiser Permanente large US real world cohort #CROI2025:

•141 received LA CAB
•25% had never taken PrEP
•75% persistence
•No incident infections
•> 90% of injections given on time

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Reposted by Prof Chloe Orkin

WHO @who.int · Mar 12

✅ WHO does not impose lockdowns or policies on countries. It does not have the authority to do this and isn't trying to get it.

Only governments can make those decisions.

Know the facts ⬇️

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 11

Open label arm of #mpox STOMP trial (people with severe disease/HIV/ pregnant/exfoliative skin) with lab confirmed mpox
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 11

Optimising on demand TDF/FTC in Cis & trans women:
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 11

ARV session part 2:

•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 11

ARV session highlights #CROI2025:
•Once yrly LEN dose tolerable with good PK
•VH499 (capsid inhibitor) with LA potential led to rapid resistance at lowest dose
•VH184 3rd gen INSTI appears potent against multiple mutations
•ZAB/TAB/LEN-1 breakthru VF (low LEN levels & single bNAb susceptibility)

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 10

For those at #CROI2025 there is a ‘Save our Science’ rally this evening at Yerba gardens next to the Moscone centre

Non US people CAN attend but you won’t be able to register

Hope to see you there @iasociety.bsky.social @hivpxresearch.bsky.social @bhiva.bsky.social

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 9

National datasets with data or guidelines on gender identity and sexuality have been removed off CDC (centre for disease control ) government websites in recent months. I am here to listen to science on vaccines at a time when high profile meetings on flu strains have been cancelled/ postponed.

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 9

Unlike federally employed US scientists I have been able to travel here(they are subject to a travel ban). I am able to present data that reports on gender identity (this is banned for government employees as part of the war on ‘woke’ which prevents all research on transgender people and GAHT).

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 9

Post from #CROI2025 San Francisco:

I have been re-posting recently to amplify voices of US colleagues on the war on science and public health that is taking place in the US and the cuts to public funding for PEPFAR HIV programmes supporting treatment and HIV prevention for millions worldwide.

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 8

@qmul.ac.uk @blizardinstitute.bsky.social @bhiva.bsky.social

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 8

At a time where these principles are under siege 🇺🇸 let’s stand proud and together. Let’s commit to be better and to do better 🏳️‍🌈✊🏿♿️🏳️‍⚧️

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Prof Chloe Orkin @profchloeorkin.bsky.social · Mar 8

Let’s all keep fighting for equity diversity and inclusion, for a better understanding of intersectionality. Let’s remember that the playing field is not level for all women to succeed.

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