@psybalazs.bsky.social
If different addictions are the just different manifestations of the same underlying condition and #psychedelics-assisted therapy addresses that condition, then it should work about the same for all forms of addictions.
March 22, 2025 at 11:35 PM
If different addictions are the just different manifestations of the same underlying condition and #psychedelics-assisted therapy addresses that condition, then it should work about the same for all forms of addictions.
Criticisms of psychedelic trials focus on positive expectancy in the psychedelic arms (eg. tinyurl.com/3bmj7ykb), but maybe eliminating disappointment in the control arms is just as important. How to do that? Well, I have ideas ... wait for the paper here or catch me at my next conference talk :)
History repeating: guidelines to address common problems in psychedelic science - PubMed
Research in the last decade has expressed considerable optimism about the clinical potential of psychedelics for the treatment of mental disorders. This optimism is reflected in an increase in researc...
tinyurl.com
February 4, 2025 at 9:44 PM
Criticisms of psychedelic trials focus on positive expectancy in the psychedelic arms (eg. tinyurl.com/3bmj7ykb), but maybe eliminating disappointment in the control arms is just as important. How to do that? Well, I have ideas ... wait for the paper here or catch me at my next conference talk :)
Why is the placebo effect diminished in psychedelic trials? IMO its the 'know-cebo' effect: the disappointment when patients realize they are in the placebo group. No patient wants to be control, but noticing it is much easier in psychedelic trials due to their intense effects.
February 4, 2025 at 9:44 PM
Why is the placebo effect diminished in psychedelic trials? IMO its the 'know-cebo' effect: the disappointment when patients realize they are in the placebo group. No patient wants to be control, but noticing it is much easier in psychedelic trials due to their intense effects.
I checked the data from a 2021 meta analysis of traditional AD trials (tinyurl.com/4am6vuyv) where in total 304 placebo arms were included. In all of them patients improved, showing just how odd is the result from the Cybin trial.
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
All antidepressants were more efficacious than placebo in adults with major depressive
disorder. Smaller differences between active drugs were found when placebo-controlled
trials were included in the...
tinyurl.com
February 4, 2025 at 9:44 PM
I checked the data from a 2021 meta analysis of traditional AD trials (tinyurl.com/4am6vuyv) where in total 304 placebo arms were included. In all of them patients improved, showing just how odd is the result from the Cybin trial.
An extreme example of the lack of placebo effect in psychedelic trials is the interim analysis of a Cybin trial, where patients in the placebo group got WORSE after dosing (its a depression scale, so higher is worse; tinyurl.com/3aw9j74d )!
Cybin Announces Unprecedented Positive Phase 2 Interim Data for CYB003 in Major Depressive Disorder Meeting Primary Efficacy Endpoint with Rapid and Significant Improvements in Depression Symptoms Aft...
Cybin Inc. (NYSE American:CYBN) (NEO:CYBN) (“Cybin” or the “Company”), a clinical-stage biopharmaceutical company committed to revolutionizing mental
tinyurl.com
February 4, 2025 at 9:44 PM
An extreme example of the lack of placebo effect in psychedelic trials is the interim analysis of a Cybin trial, where patients in the placebo group got WORSE after dosing (its a depression scale, so higher is worse; tinyurl.com/3aw9j74d )!
The placebo effect is ~4 points lower on the Hamilton scale (HAMD17) in psychedelic trials' placebo arm. For context, this 4 points is about twice the effect as the difference between placebo and traditional ADs.
February 4, 2025 at 9:44 PM
The placebo effect is ~4 points lower on the Hamilton scale (HAMD17) in psychedelic trials' placebo arm. For context, this 4 points is about twice the effect as the difference between placebo and traditional ADs.