3. The effect of the interaction between TMS E-fields and functional brain networks on clinical outcome was evident within 5 TMS sessions, i.e a fraction (5/30) of the full TMS dose. This suggests that robust responses to TMS can occur early when the right functional networks are engaged.

2. E-field magnitude at the peak sgACC-anticorrelated voxel in the prefrontal cortex was associated with treatment response: ⬆️ E-field magnitude at sgACC-anticorrelated peak, ⬆️ reduction in depression symptoms post treatment. True regardless of whether we normalize the w.r.t. overall E-field.

1. Resting state functional connectivity between the “E-field center of gravity” and the subgenual anterior cingulate cortex (sgACC) was associated with symptom reduction: ⬆️ E-field CoG-sgACC anticorrelation, ⬆️ reduction in depression symptoms post treatment. Without E-fields, no clear relationship.

So excited for this!