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Roham Parsa

@rohamparsa.bsky.social

830 followers 75 following 35 posts

Group Leader at the Chan Zuckerberg Biohub New York. Adjunct Assistant Professor at The Rockefeller University. Immunologist with a passion for T cells! parsalab.org

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Roham Parsa @rohamparsa.bsky.social · Aug 29

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

Reposted by Roham Parsa

Iliev Lab @ilievlab.bsky.social · 26d

Just a few days left for scholarship and short talk submissions!
Science, snow, and exciting advances in fungal and immunology research🔬 🍄❄️Claim your spot! #KSFUNGALPATH26 www.keystonesymposia.org/conferences/...

Fungal Pathogens: Emerging Threats and Future Challenges | Keystone Symposia

Join us at the Keystone Symposia on Fungal Pathogens: Emerging Threats and Future Challenges, January 2026, in Breckenridge, with field leaders!

www.keystonesymposia.org

Roham Parsa @rohamparsa.bsky.social · Aug 29

Many thanks to @danmucida.bsky.social and all our co-authors for their contributions to this work!

Roham Parsa @rohamparsa.bsky.social · Aug 29

We believe these findings provide important insights into how T cells adapt across organs and how tissue cues shape both their function and clonal expansion. We also hope that TRACK mice will be a valuable tool for the scientific community studying T cell dynamics in health and disease.

Roham Parsa @rohamparsa.bsky.social · Aug 29

Interestingly, early clonal segregation during infection evolved into greater inter-organ sharing, leading to clonal equilibrium over time, likely driven by retrograde migration previously reported in CD8 T cells. Additionally, TCR specificity converged on a few viral proteins at the memory stage.

Roham Parsa @rohamparsa.bsky.social · Aug 29

During viral infection, different tissues, including secondary lymphoid organs, not only shape the transcriptional profile of CD4 T cells but also control the expansion of specific clones, likely driven by TCR specificity and each tissue’s unique antigen landscape.

Roham Parsa @rohamparsa.bsky.social · Aug 29

The novel TRACK mice we developed allow us to carefully follow recently activated, antigen-agnostic polyclonal CD4 T cells during perturbations (controlled by tamoxifen) and determine how they are clonally selected and transcriptionally defined across organs.

Roham Parsa @rohamparsa.bsky.social · Aug 29

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

Roham Parsa @rohamparsa.bsky.social · May 5

ICQ !!!

Roham Parsa @rohamparsa.bsky.social · Apr 7

One project is to determine how T cells adapts to various tissue environments and how long this information is stored within the cell. The second project is to develop novel tools to track T cell migration across organs.

Please spread the word! #postdoc #STEMjobs #sciencejobs #czbiohub

Roham Parsa @rohamparsa.bsky.social · Apr 7

Hi, we are looking for two motivated postdocs to join our group!

job-boards.greenhouse.io/chanzuckerbe...

job-boards.greenhouse.io/chanzuckerbe...

Research Scholar, T cell Tissue Adaptation and Residency (Parsa Group - Biohub NY)

New York, New York, United States

job-boards.greenhouse.io

Reposted by Roham Parsa

Justin Eyquem @j-eyquem.bsky.social · Feb 4

🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇

sciencedirect.com/science/arti...

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

sciencedirect.com

Roham Parsa @rohamparsa.bsky.social · Feb 5

Congrats Justin! Amazing work

Roham Parsa @rohamparsa.bsky.social · Jan 17

We're recruiting new Group Leaders and Platform Leaders at Chan Zuckerberg Biohub New York! Our mission: to decode and understand the language of the immune system to better detect and treat cancer, autoimmunity, and neurodegenerative diseases.

www.czbiohub.org/careers/?loc...

#newPI #ScienceJobs

Career Opportunities at the CZ Biohub Network

Find job openings at the CZ Biohub Network.

www.czbiohub.org

Reposted by Roham Parsa

Ciça Canesso @cicacanesso.bsky.social · Dec 21

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....

Identification of antigen-presenting cell–T cell interactions driving immune responses to food

The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

www.science.org

Roham Parsa @rohamparsa.bsky.social · Dec 20

Beautiful work from my talented friend @cicacanesso.bsky.social

Sarah Ross @sarahhross.bsky.social · Dec 19

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

Roham Parsa @rohamparsa.bsky.social · Dec 17

We are looking for a Research Assistant! Come and build a great science team with me! #STEMjobs #ImmunoSky

job-boards.greenhouse.io/chanzuckerbe...

Research Associate - Parsa Group

New York, New York, United States

job-boards.greenhouse.io

Reposted by Roham Parsa

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Roham Parsa @rohamparsa.bsky.social · Dec 6

Mug competition with @cyrilpedia.bsky.social , gift to me from @danmucida.bsky.social lab, immunologists best friend

Roham Parsa @rohamparsa.bsky.social · Dec 2

Santa came early this year :) #newPI

Roham Parsa @rohamparsa.bsky.social · Nov 30

Anyone knows where I can find some influenza PR8 proteins, specifically - M2, PB2 and PA… I’ll send you some top quality Swedish candy :)

Roham Parsa @rohamparsa.bsky.social · Nov 29

Here is the commentary published in Cell regarding this topic!

www.cell.com/cell/abstrac...

Problem choice and decision trees in science and engineering

Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for eva...

Roham Parsa @rohamparsa.bsky.social · Nov 29

Great podcast! Everyone—graduate students, postdocs, and new PIs—should listen to this episode!

The Night Science Podcast @nightsciencepod.bsky.social · Nov 25

New Night Science Podcast episode! Stanford's Michael Fischbach talks about choosing a research problem, managing risks, and turning crises into opportunities; as discussed in his Cell paper "Problem choice and decision trees in science and engineering"
www.buzzsprout.com/1744020/epis...

66 | Michael Fischbach and the scientific decision tree - Night Science

In this episode, Stanford professor Michael Fischbach discusses insights from his course on how to choose meaningful research problems. Highlights include:- Invest time in problem selection: Spend mor...

www.buzzsprout.com

Roham Parsa @rohamparsa.bsky.social · Nov 28

And as a bonus—the position is based in the heart of New York City! Beyond the exciting scientific opportunities, you’ll have access to the vibrant, culturally rich, and inspiring environment that makes New York such an extraordinary place to live and work.

Roham Parsa @rohamparsa.bsky.social · Nov 28

CZ Biohub NY is affiliated with three powerhouse institutions—The Rockefeller University, Columbia University, and Yale University. This provides opportunities to engage with leading scientists, attend world-class lectures, and access cutting-edge technologies across these institutions.

Roham Parsa @rohamparsa.bsky.social · Nov 28

I’m looking for a postdoc to join my group here at Chan Zuckerberg Biohub NY! This position offers the chance to delve deeply into the dynamic and functional behavior of T cells, exploring how their fate decisions shape immune responses in health and disease.

More information at parsalab.science

The Parsa Laboratory at CZ Biohub New York

The Parsa laboratory investigates the functional and clonal dynamics of T cells during various immune responses. Using innovative genetic approaches, we will precisely track and analyze the behavior of polyclonal perturbation-specific T cells over time and space. We seek to uncover the rules governing the development of effector and memory T cells, ultimately enhancing our understanding of adaptive immunity and advancing therapies for various diseases, including cancer and autoimmunity.

parsalab.science