How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Amazing news! Congratulations and good luck!

I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:

www.fmi.ch/education-ca...

Also grateful to Ellen Potoczky and Alpha Yap
@yap-lab.bsky.social for their elegantly written focus article about our paper!🔗 tinyurl.com/287yv4pn

Many thanks to the labs of Michiyuki Matsuda, Beth Pruitt & Harmjan Vos for their valuable contributions! Special thanks as well to the huge effort of Willem-Jan Pannekoek and other people from the Gloerich lab that made this work possible.

Phosphoproteomics and transcriptomics of stretched epithelial monolayers revealed that mechanical strain activates EGFR-ERK signaling via E-cadherin mechanotransduction. How? Intercellular forces transduced by E-cadherin trigger ADAM-mediated shedding of EGFR ligands that drive downstream signaling.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

I have a 1 year fellowship available (MSc level) for someone interested in studying how nuclear mechanics regulates the timing of mitotic entry. Plus it´s in the beautiful city of Porto! Please spread the word to anyone who might be interested. dozer.i3s.up.pt/applicationm...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

What happens between cells with adhesion differences in crowded tissues? Mechanical cell competition!

Check the final version of our study to learn more about compression-independent cell elimination, interactions at tissue interfaces and the role of force transmission in that

tinyurl.com/4yw97bm3

Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student!

werkenbij.amsterdamumc.org/en/vacatures...

📣Funded #PhDposition! – Pls RT!
Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging.
Join us @VetmeduniVienna in a vibrant research environment!
#CancerResearch #PhD
👉 euraxess.ec.europa.eu/jobs/302158

That's amazing! Congrats @alexandralong.bsky.social!

Super interesting work!

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA

Thanks for creating this pack. I would be happy to join, thanks!

Perfect reason for my first post here. Super excited to see this work on PIEZO mechanosensing of the intestinal stem cell niche led by Meryem Baghdadi @vignjeviclab.bsky.social and Kim lab out in Science! Honored to have contributed to this story as 2nd author. 🎉

www.science.org/doi/10.1126/...

That's great, I would love to be added!