RSC Chemical Biology
@rscchembio.rsc.org
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.
🌐 Website: rsc.li/rscchembio Published by @rsc.org
🌐 Website: rsc.li/rscchembio Published by @rsc.org
#RSCChemBio Issue 12 is now online and #openaccess!
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
November 27, 2025 at 11:16 AM
#RSCChemBio Issue 12 is now online and #openaccess!
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more!
📰Read the full issue here: pubs.rsc.org/en/journals/...
Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
November 14, 2025 at 10:45 AM
Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.
👉 Read the full paper here: doi.org/10.1039/D5CB...
Fresh from Yogo Sakakibara et al.!
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
November 12, 2025 at 12:10 PM
Fresh from Yogo Sakakibara et al.!
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."
👉Read the full article here: doi.org/10.1039/D5CB...
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
November 5, 2025 at 8:04 AM
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
October 29, 2025 at 12:32 PM
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
October 21, 2025 at 2:30 PM
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
October 15, 2025 at 1:48 PM
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
October 7, 2025 at 1:21 PM
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
October 2, 2025 at 3:06 PM
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
October 1, 2025 at 2:36 PM
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
September 23, 2025 at 12:49 PM
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
September 18, 2025 at 11:00 AM
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
September 17, 2025 at 11:16 AM
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
September 16, 2025 at 10:47 AM
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
September 9, 2025 at 12:41 PM
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch
September 3, 2025 at 3:05 PM
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch
🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology.
🔗 Read now: https://rsc.li/cbbmt25
🔗 Read now: https://rsc.li/cbbmt25
August 26, 2025 at 12:00 PM
🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology.
🔗 Read now: https://rsc.li/cbbmt25
🔗 Read now: https://rsc.li/cbbmt25
Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
August 11, 2025 at 2:57 PM
Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
New in RSC Chemical Biology: EBI ⚡ — promising for food safety, but how can AI 🤖, MAP, and natural antimicrobials 🌱 help scale it up? We explore solutions in our latest review.
🔗 Read full article: doi.org/10.1039/D5CB...
#FoodSafety #EmergingTech #RSCChemicalBiology
🔗 Read full article: doi.org/10.1039/D5CB...
#FoodSafety #EmergingTech #RSCChemicalBiology
July 21, 2025 at 6:47 PM
New in RSC Chemical Biology: EBI ⚡ — promising for food safety, but how can AI 🤖, MAP, and natural antimicrobials 🌱 help scale it up? We explore solutions in our latest review.
🔗 Read full article: doi.org/10.1039/D5CB...
#FoodSafety #EmergingTech #RSCChemicalBiology
🔗 Read full article: doi.org/10.1039/D5CB...
#FoodSafety #EmergingTech #RSCChemicalBiology
Excited to sponsor the 21st Tri-Institutional Chemical Biology Symposium on Aug 28 at @mskcancercenter.bsky.social 🎉
RSC Chemical Biology + @rscmedchem.rsc.org are proud to support this event 👩🔬👨🔬
Poster subs open! Reg by Aug 20 🔬🧪
#ChemBio #MedChem #TPCB #RSCJournals
RSC Chemical Biology + @rscmedchem.rsc.org are proud to support this event 👩🔬👨🔬
Poster subs open! Reg by Aug 20 🔬🧪
#ChemBio #MedChem #TPCB #RSCJournals
July 21, 2025 at 12:01 PM
Excited to sponsor the 21st Tri-Institutional Chemical Biology Symposium on Aug 28 at @mskcancercenter.bsky.social 🎉
RSC Chemical Biology + @rscmedchem.rsc.org are proud to support this event 👩🔬👨🔬
Poster subs open! Reg by Aug 20 🔬🧪
#ChemBio #MedChem #TPCB #RSCJournals
RSC Chemical Biology + @rscmedchem.rsc.org are proud to support this event 👩🔬👨🔬
Poster subs open! Reg by Aug 20 🔬🧪
#ChemBio #MedChem #TPCB #RSCJournals
New in RSC Chemical Biology: SpyBLI — a fast, low-cost way to measure binding kinetics straight from crude samples. No purification, no cloning, data in under 24h. A game-changer for binder engineering!
DOI doi.org/10.1039/D5CB...
#ProteinEngineering #SpyBLI
DOI doi.org/10.1039/D5CB...
#ProteinEngineering #SpyBLI
July 18, 2025 at 2:53 PM
New in RSC Chemical Biology: SpyBLI — a fast, low-cost way to measure binding kinetics straight from crude samples. No purification, no cloning, data in under 24h. A game-changer for binder engineering!
DOI doi.org/10.1039/D5CB...
#ProteinEngineering #SpyBLI
DOI doi.org/10.1039/D5CB...
#ProteinEngineering #SpyBLI
We're pleased to announce that Cecilie Mia Jørgensen (@ceciliejoergensen.bsky.social) has won the RSC Chem. Biol. and Org. Biomol. Chem. (@orgbiomolchem.rsc.org) poster award at the 2025 Peptide and Protein Science Group Early Stage Researcher Meeting! Please join us in congratulating Cecilie.
July 16, 2025 at 11:08 AM
We're pleased to announce that Cecilie Mia Jørgensen (@ceciliejoergensen.bsky.social) has won the RSC Chem. Biol. and Org. Biomol. Chem. (@orgbiomolchem.rsc.org) poster award at the 2025 Peptide and Protein Science Group Early Stage Researcher Meeting! Please join us in congratulating Cecilie.
Exciting news! Our Editorial Board member, Ali Tavassoli, has won the 2025 Interdisciplinary Prize! 🎉
Ali is being recognised for pioneering creating new approaches to target "undruggable" protein–protein interactions.
Check out Ali's work here 👉 doi.org/10.1039/C8SC...
Ali is being recognised for pioneering creating new approaches to target "undruggable" protein–protein interactions.
Check out Ali's work here 👉 doi.org/10.1039/C8SC...
June 26, 2025 at 10:04 AM
Exciting news! Our Editorial Board member, Ali Tavassoli, has won the 2025 Interdisciplinary Prize! 🎉
Ali is being recognised for pioneering creating new approaches to target "undruggable" protein–protein interactions.
Check out Ali's work here 👉 doi.org/10.1039/C8SC...
Ali is being recognised for pioneering creating new approaches to target "undruggable" protein–protein interactions.
Check out Ali's work here 👉 doi.org/10.1039/C8SC...
#ChemBioParis2025
🚨 Early Bird Registration & Abstract Submission CLOSES TOMORROW!
Register & send you abstract today!
📍 Sorbonne Université, Paris
📆 6-9 October, 2025
Register below 👇
🔗 lnkd.in/dpfzrSpX
#ICBS2025 #ECBS2025 #ChemBio
🚨 Early Bird Registration & Abstract Submission CLOSES TOMORROW!
Register & send you abstract today!
📍 Sorbonne Université, Paris
📆 6-9 October, 2025
Register below 👇
🔗 lnkd.in/dpfzrSpX
#ICBS2025 #ECBS2025 #ChemBio
June 23, 2025 at 2:04 PM
#ChemBioParis2025
🚨 Early Bird Registration & Abstract Submission CLOSES TOMORROW!
Register & send you abstract today!
📍 Sorbonne Université, Paris
📆 6-9 October, 2025
Register below 👇
🔗 lnkd.in/dpfzrSpX
#ICBS2025 #ECBS2025 #ChemBio
🚨 Early Bird Registration & Abstract Submission CLOSES TOMORROW!
Register & send you abstract today!
📍 Sorbonne Université, Paris
📆 6-9 October, 2025
Register below 👇
🔗 lnkd.in/dpfzrSpX
#ICBS2025 #ECBS2025 #ChemBio
The Early Stage Researcher Meeting 2025 at @unibirmingham.bsky.social is on July 10!
The @rsc-ppsg.bsky.social event includes oral presentations by PhD students, postdoc researchers, and a poster award session.
🗓️ Register by June 20
👉 https://bit.ly/3TsMCFK
#PPSG2025
The @rsc-ppsg.bsky.social event includes oral presentations by PhD students, postdoc researchers, and a poster award session.
🗓️ Register by June 20
👉 https://bit.ly/3TsMCFK
#PPSG2025
June 17, 2025 at 4:00 PM
The Early Stage Researcher Meeting 2025 at @unibirmingham.bsky.social is on July 10!
The @rsc-ppsg.bsky.social event includes oral presentations by PhD students, postdoc researchers, and a poster award session.
🗓️ Register by June 20
👉 https://bit.ly/3TsMCFK
#PPSG2025
The @rsc-ppsg.bsky.social event includes oral presentations by PhD students, postdoc researchers, and a poster award session.
🗓️ Register by June 20
👉 https://bit.ly/3TsMCFK
#PPSG2025