Lightnews — Scholar-powered news

Sauer Lab @sauer-lab.bsky.social · Aug 19

🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.

▶️ www.biorxiv.org/content/10.1...

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Reposted by Sauer Lab

SMLMS 2025 @smlm-symposium.bsky.social · Jun 17

Welcome to the youngSMLMS, a pre-SMLMS event for students, PhDs & PostDocs!
We’ll explore science & career in workshops, talks, roundtables, a panel and with time to network.
--> Thanks to our sponsors, youngSMLMS is free & we cover accommodation for all presenting their work. Thus, register now!

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Reposted by Sauer Lab

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Apr 25

Fully Funded PhD Scholarship in Centrosome Biology in the lab of Prof Ciaran Morrison: www.findaphd.com/phds/project...

Fully Funded PhD Scholarship in Centrosome Biology at University of Galway on FindAPhD.com

PhD Project - Fully Funded PhD Scholarship in Centrosome Biology at University of Galway, listed on FindAPhD.com

www.findaphd.com

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Sauer Lab @sauer-lab.bsky.social · Mar 29

Amazing, congratulations!

Luke Lavis @rhodamine110.bsky.social · Mar 28

How it started: About eight years ago Bob Tjian ("Tij") and I sat in the back of cab in San Francisco and discussed the crazy idea of using live-cell single-molecule tracking for high-throughput drug screening.

How it's going:

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Reposted by Sauer Lab

Bornabrit1 @lindarothwell.bsky.social · Mar 4

Look what's happening at the French Embassy in Washington DC.

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Reposted by Sauer Lab

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Feb 12

Chemical Solutions to Structural Biology symposium.
Registration and abstract submission now open:

isbuc.ku.dk/chemical-sol...

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Reposted by Sauer Lab

Jörg Enderlein @joergenderlein.bsky.social · Feb 14

An excellent review about fluorescence labeling strategies by @beliulab.bsky.social Gerti Beliu and colleagues from Würzburg University - highly recommended reading for everybody interested in fluorescence microscopy!

Biophysical Reports @biophysreports.bsky.social · Feb 14

Online now! Fluorescent labeling strategies for molecular bioimaging. Marcel Streit, Made Budiarta, Marvin Jungblut, and Gerti Beliu. www.cell.com/biophysrepor...

Fluorescent labeling strategies for molecular bioimaging

Super-resolution microscopy (SRM) has transformed biological imaging by circumventing the diffraction limit of light and enabling the visualization of cellular structures and processes at the molecula...

www.cell.com

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Sauer Lab @sauer-lab.bsky.social · Feb 12

🆕 Our new functionalized docetaxel probe enables superior visualization of dense mitotic spindle structures during cell division by expansion microscopy!

▶️ pubs.acs.org/doi/10.1021/...

Functionalized Docetaxel Probes for Refined Visualization of Mitotic Spindles by Expansion Microscopy

Visualizing the ultrastructure of mitotic spindles, the macromolecular machines that segregate chromosomes during mitosis, by fluorescence imaging remains challenging. Here we introduce an azido- and ...

pubs.acs.org

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Reposted by Sauer Lab

GdR ImaBio @gdrimabio.bsky.social · Feb 7

SAVE THE DATE 👇

#FiNS2025
Frontiers in Neurophotonics Symposium 2025
frontiersneurophotonics.org

#Bordeaux, 6-9 Oct 2025

@iins-bordeaux.bsky.social
@cnrs.bsky.social
@univbordeaux.bsky.social
@neurobordeaux.bsky.social
@cnrsbiologie.bsky.social
@gaellerecher.bsky.social

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Reposted by Sauer Lab

Fyodor Urnov @urnov.bsky.social · Feb 10

NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.

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Reposted by Sauer Lab

Julius-Maximilians-Universität Würzburg @uni-wuerzburg.de · Jan 10

Delighted to launch our activities on Bluesky with this great news: Our researchers @sauer-lab.bsky.social show in @science.org, how therapeutic #antibodies interact with B cells – thanks to an innovative method of super-resolution microscopy. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...

Mode of action of the new microscopy method LLS-TDI-DNA-PAINT. On the top right, the RTX antibody was visualised on a Raij-B cell: it is easy to see how it links the CD20 molecules in the membrane. Bottom right: the hedgehog-shaped appearance of a living Raji B cell after the antibody has bound. The surface protein CD45, which is homogeneously distributed on the cell surface, is also labelled in green. (Image: Arindam Ghosh / University of Würzburg)

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Sauer Lab @sauer-lab.bsky.social · Jan 10

🔬 Ever wondered how therapeutic antibodies work?
3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies.

📄 Read more: www.science.org/doi/10.1126/...

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Reposted by Sauer Lab

Jörg Enderlein @joergenderlein.bsky.social · Jan 10

Super happy to see the manuscript of my former PhD student and close friend Arindam Ghosh, @arindam92.bsky.social, and the Markus Sauer lab, @sauer-lab.bsky.social, being pblished in Science: www.science.org/doi/10.1126/...

Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy

Elucidating the interaction between membrane proteins and antibodies requires whole-cell imaging at high spatiotemporal resolution. Lattice light-sheet (LLS) microscopy offers fast volumetric imaging ...

www.science.org

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Sauer Lab @sauer-lab.bsky.social · Dec 5

Well-deserved Luke

Luke Lavis @rhodamine110.bsky.social · Dec 5

Gregorio Weber is a giant in our field, and I am deeply honored to receive this award in his name. I want to acknowledge all my collaborators over the years—especially @dyerfulchymist.bsky.social—and the place that made everything possible: @hhmijanelia.bsky.social

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Reposted by Sauer Lab

Benjamin Compans @bencompans.bsky.social · Dec 2

Happy to see my MSCA project with @jbneuro.bsky.social lab available on @biorxiv-neursci.bsky.social

We Increased network activity in vivo and used dSTORM to look at the nanoscale organization of inhibitory synapses formed onto the AIS and onto tufts dendrites of L2/3 S1 Cortex!

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