Rainer Machné
@selfsplicing.bsky.social
130 followers 550 following 19 posts
i splice myself when i think about o2
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Reposted by Rainer Machné
biorxiv-evobio.bsky.social
Opposing Copy Number Variation Dynamics Shape Adaptation to Glucose and Galactose in Diploid Yeast https://www.biorxiv.org/content/10.1101/2025.10.01.679718v1
Reposted by Rainer Machné
tobiaswarnecke.bsky.social
Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
meetings.embo.org
Reposted by Rainer Machné
tobiaswarnecke.bsky.social
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Supervisors and Projects
www.bioch.ox.ac.uk
Reposted by Rainer Machné
paveltomancak.bsky.social
To know what WoodstockBio2 & Night Science was really like - you had to be there! As you read about it in @nature.com, be aware that none if this would have happened without the vision, hard work, leadership & passion of @svobodalab.bsky.social
Who was there - knows!

www.nature.com/articles/d41...
Scientific bedlam at the world’s weirdest and wildest research conference
Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.
www.nature.com
selfsplicing.bsky.social
Finding causal structures behind correlations is a key task of science. In biology, we have to do that for evolved, highly connected homeostatic feedback systems. How?

Moving from "pseudo steady state" assumptions to time series may be the only option.
selfsplicing.bsky.social
i loved that poster, as an antipode to mine, just 4 m away, over-crowded on purpose (>10 y work), but also converging on ribosomes (regulation of)
selfsplicing.bsky.social
sounds like a great weekend read, care to share a link?
selfsplicing.bsky.social
Unpopular opinion: I love posters and find them underrated as a form of less linear science communication. There should be platforms to publish in poster format, with supporting online material. My latest one, I loved to present in the Bohemian woods #theconferencetoendallconferences #tcteac
Reposted by Rainer Machné
apoetsch.bsky.social
We have several open postdoc positions! We do computational biology 🧬🖥️ and deep learning to understand the genomics of genome instability and (somatic) genome evolution in ageing and cancer. Interested? 👉🏻 more details: tu-dresden.de/cmcb/biotec/...
Open positions
We are looking for Postdocs! If you are interested in the lab in general as a postdoc, please feel free to apply with an open application, including a letter of motivation and a CV …
tu-dresden.de
Reposted by Rainer Machné
mollygale.bsky.social
🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Barbara McClintock portrait
Reposted by Rainer Machné
jesseveenvliet.bsky.social
Indeed Oded. Some Will think of #TCTeAC as escapism, but I think it was showing us how beautiful we can make this world if the guiding values are respect & trust, and if world leaders would adopt a vision that is based on hope instead of hatred. On collaboration instead of competition. 💚
selfsplicing.bsky.social
This seems like a very solid DIY benchtop reactor design, including a jacketed vessel that allows for calorimetry: www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Rainer Machné
helenajambor.bsky.social
A very short summary of "Data Visualization against fascism":

Fascism conceals truths, disregards evidence-based decision-making, and jeopardizes the education of the next generation. Standing up against means: MONITOR, EXPOSE, and EDUCATE. As scientists we are ready for this!

#TCTeAC
selfsplicing.bsky.social
or perhaps somebody was really quick to capture this iconic moment in art :p bsky.app/profile/elis...
elisecutts.bsky.social
@odedrechavi.bsky.social says he wants to change science for the better.

How? I’m still not quite sure. But 1.5 days into #TCTeAC, the plan seems to involve, among other things, walk-up songs, jumping, dancing, and a hefty serving of joy.
selfsplicing.bsky.social
Ah thanks. I didn't see the creepy babies, but the spider man at the river may be Cžerny as well then.
Reposted by Rainer Machné
natanellae.bsky.social
How was your conference? Mine was #TCTeAC
selfsplicing.bsky.social
Can anyone explain the background of this statue? It was hanging at Lucerna.
selfsplicing.bsky.social
Everybody is just talking about the fun #TCTeAC but the high quality of science, across a diverse range of fields, was equally impressive. Thanks to the organizers, such a unique event.
selfsplicing.bsky.social
More support for the relevance of the twin-domain model of transcription by Sam Meyer's lab: gyrase binding is increased many kb downstream of highly expressed genes, topoI upstream. Context matters.
academic.oup.com/nar/article/...
topoisomerase I and gyarse binding upstream and downstream of transcription units
selfsplicing.bsky.social
i fear that the tesla person is just the designated fall guy
selfsplicing.bsky.social
Psoralen's use in genomewide footprinting of torsional strain (TMP-seq) has been limited. It seems that beautiful data can be obtained with a good reference measurement. Now, we can start to study the twin domain model on a genome-wide scale.

elifesciences.org/reviewed-pre...
High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation
elifesciences.org