Hunter Shain
@shainlab.bsky.social
UCSF, Department of Dermatology. Part of HTAN. Cancer, genomics, melanoma, cutaneous squamous cell carcinoma, dermatology, somatic mutations, tumor evolution, spatial transcriptomics, single-cell
Pinned
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Nature Communications - The evolution of cutaneous squamous cell carcinoma (cSCC) remains poorly understood. Here, the authors employ multi-omics and multi-scale analyses to explore the genetic...
www.nature.com
I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...
What drives the earliest steps of skin cancer development?
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
December 2, 2025 at 12:32 AM
What drives the earliest steps of skin cancer development?
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
In keratinocyte cancers, the first selected mutations almost always hit TP53 and NOTCH genes—plus occasional hits in chromatin remodeling genes or the Hippo pathway.
I remain stunned by this finding -- melanocytes have 5x more mutations than keratinocytes, despite the fact that the cells are next to each other in the basal layer of the epidermis, [theoretically] experiencing the same doses of UV radiation.
November 29, 2025 at 5:22 PM
I remain stunned by this finding -- melanocytes have 5x more mutations than keratinocytes, despite the fact that the cells are next to each other in the basal layer of the epidermis, [theoretically] experiencing the same doses of UV radiation.
I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Nature Communications - The evolution of cutaneous squamous cell carcinoma (cSCC) remains poorly understood. Here, the authors employ multi-omics and multi-scale analyses to explore the genetic...
www.nature.com
November 27, 2025 at 4:11 PM
I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...
Too small!
November 15, 2025 at 3:57 AM
Too small!
Reposted by Hunter Shain
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
November 14, 2025 at 8:49 PM
Today at 4pm: Cancer Center Friday Seminar | Ashley Kiemen, PhD, Johns Hopkins Inst for NanoBioTechnology "Integration of histology and multiplex imaging for targeted understanding of pancreatic cancer progression" cancer.ucsf.edu/seminars Host: @shainlab.bsky.social @ucsanfrancisco.bsky.social
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
November 6, 2025 at 3:49 PM
Nancy Pelosi is retiring after decades of service. I still remember when I received my first R01, and she sent me a congratulatory letter!
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
October 24, 2025 at 8:07 PM
1/ Should you get feedback on your grant proposals?
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
Sure — but do it right. And take positive feedback with a grain of salt. 🧂
What is your favorite gene expression deconvolution software?
October 21, 2025 at 7:36 PM
What is your favorite gene expression deconvolution software?
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
October 19, 2025 at 2:47 AM
Hey @bontahill.bsky.social , who are you rooting for? Stanford or FSU?
Reposted by Hunter Shain
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
a dog is sitting on a rug in front of a brick wall and a plant .
ALT: a dog is sitting on a rug in front of a brick wall and a plant .
media.tenor.com
October 16, 2025 at 12:25 AM
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Reposted by Hunter Shain
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
October 9, 2025 at 2:01 PM
A bundle of interesting papers just dropped on Nature. Collectively, they describe the somatic mutational landscapes normal tissues.
Reposted by Hunter Shain
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Dear collaborator, I am writing to confirm support for your grant. Before I write one sentence describing my tiny role on your project, please read 3 paragraphs about how awesome your grant is, which I definitely wrote myself.
October 7, 2025 at 3:37 PM
Dear collaborator, I am writing to confirm support for your grant. Before I write one sentence describing my tiny role on your project, please read 3 paragraphs about how awesome your grant is, which I definitely wrote myself.
What a satisfying mate!
September 30, 2025 at 2:40 PM
What a satisfying mate!
Reposted by Hunter Shain
I felt it #moderate
#California #quake M4.8 | 3 km ESE of Berkeley, California | 1m ago | Sep 22, 2025 01:56 am (Pacific Standard Time)
Did you feel it? Submit a report!
#moderate #M2+ #M3+ #M4+ #United_States #California
Did you feel it? Submit a report!
#moderate #M2+ #M3+ #M4+ #United_States #California
Moderate magnitude 4.8 earthquake at 9 km depth
See detailed quake info, read user reports, submit your own if you felt it!
www.volcanodiscovery.com
September 22, 2025 at 1:48 PM
I felt it #moderate
Earthquake! Bay Area
September 22, 2025 at 9:58 AM
Earthquake! Bay Area
RFK said he would determine the cause of autism by "September" and Trump has pre-announced a major announcement on autism to come on Monday. 🍿
September 21, 2025 at 3:22 PM
RFK said he would determine the cause of autism by "September" and Trump has pre-announced a major announcement on autism to come on Monday. 🍿
STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution
September 21, 2025 at 3:21 PM
STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution
Does anyone else have dogs that ruin their sleep score? I was all good till 7am, but then an intermittent Mastiff with a HrV of 300 took over
September 20, 2025 at 4:53 AM
Does anyone else have dogs that ruin their sleep score? I was all good till 7am, but then an intermittent Mastiff with a HrV of 300 took over
After clearly saving changes to an NIH RPPR form, the system inevitably gives this warning.
September 18, 2025 at 3:36 PM
After clearly saving changes to an NIH RPPR form, the system inevitably gives this warning.
Serious question for the crowd: has a K-awardee ever actually done the coursework/mentor meetings they promised in the training plan? Or is it just a rite of passage?
September 16, 2025 at 3:29 PM
Serious question for the crowd: has a K-awardee ever actually done the coursework/mentor meetings they promised in the training plan? Or is it just a rite of passage?
Reposted by Hunter Shain
1,333 Notices issued by the NIH in the past week. Including 116 new R01 projects.
reporter.nih.gov/search/6lVq4...
reporter.nih.gov/search/6lVq4...
RePORT ⟩ RePORTER
reporter.nih.gov
September 8, 2025 at 2:12 PM
1,333 Notices issued by the NIH in the past week. Including 116 new R01 projects.
reporter.nih.gov/search/6lVq4...
reporter.nih.gov/search/6lVq4...