Stephanie Yan
@smyan.bsky.social
Human genetics & genomics | https://stephaniemyan.github.io/
Reposted by Stephanie Yan
Congrats to Dr. @saracarioscia.bsky.social and Dr. Dylan Taylor!!
May 23, 2025 at 1:44 AM
Congrats to Dr. @saracarioscia.bsky.social and Dr. Dylan Taylor!!
Reposted by Stephanie Yan
I'm defending my PhD next Friday, May 23!(!!!!). I'll be highlighting our work looking at aneuploidy in early human development. If you're interested I'd love to have you join via Zoom (DM me for info) or on the Homewood campus!
May 16, 2025 at 1:27 PM
I'm defending my PhD next Friday, May 23!(!!!!). I'll be highlighting our work looking at aneuploidy in early human development. If you're interested I'd love to have you join via Zoom (DM me for info) or on the Homewood campus!
Reposted by Stephanie Yan
Apparently not all my popgen advice is good.
April 16, 2025 at 12:09 AM
Apparently not all my popgen advice is good.
Reposted by Stephanie Yan
My main PhD work is up! See thread below. I would love to discuss! www.medrxiv.org/content/10.1...
April 7, 2025 at 2:20 PM
My main PhD work is up! See thread below. I would love to discuss! www.medrxiv.org/content/10.1...
Reposted by Stephanie Yan
Thrilled to see this work out - its been fascinating to look at statistical genetics in these IVF embryo datasets underlying meiotic aneuploidies and recombination! Joint work led with @saracarioscia.bsky.social. See thread below, thoughts welcome!
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
April 7, 2025 at 2:27 PM
Thrilled to see this work out - its been fascinating to look at statistical genetics in these IVF embryo datasets underlying meiotic aneuploidies and recombination! Joint work led with @saracarioscia.bsky.social. See thread below, thoughts welcome!
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
huge congrats to @saracarioscia.bsky.social @aabiddanda.bsky.social Margaret and @rajivmccoy.bsky.social!!!! So excited to see this out!
Aneuploidy is the leading cause of pregnancy loss. In work led by @saracarioscia.bsky.social and @aabiddanda.bsky.social, we reanalyzed genetic testing data from 139,416 IVF embryos to discover variants associated with recombination phenotypes and aneuploidy risk. www.medrxiv.org/content/10.1...
April 7, 2025 at 2:11 PM
huge congrats to @saracarioscia.bsky.social @aabiddanda.bsky.social Margaret and @rajivmccoy.bsky.social!!!! So excited to see this out!
Reposted by Stephanie Yan
Very excited to share (most of) my PhD work, in which we use human retinal organoids to understand how thyroid hormone signaling is regulated in the developing retina to promote robust and accurate photoreceptor subtype specification. Turns out, it's a lot more complicated than we expected. 1/n
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids https://www.biorxiv.org/content/10.1101/2025.03.20.644422v1
March 24, 2025 at 1:41 PM
Very excited to share (most of) my PhD work, in which we use human retinal organoids to understand how thyroid hormone signaling is regulated in the developing retina to promote robust and accurate photoreceptor subtype specification. Turns out, it's a lot more complicated than we expected. 1/n
Reposted by Stephanie Yan
Congrats to Brian Guy from my lab who became Dr. Guy PhD today!!!
April 1, 2025 at 10:10 PM
Congrats to Brian Guy from my lab who became Dr. Guy PhD today!!!
Reposted by Stephanie Yan
Check out this tour de force work from @christ3na.bsky.social in my lab!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids https://www.biorxiv.org/content/10.1101/2025.03.20.644422v1
March 24, 2025 at 10:29 PM
Check out this tour de force work from @christ3na.bsky.social in my lab!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Reposted by Stephanie Yan
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...
www.biorxiv.org
February 4, 2025 at 6:04 PM
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
Reposted by Stephanie Yan
Now: Rajiv McCoy: Genetic architecture of meiotic recombination across 90,431 in vitro fertilized embryos #ASHG24 🧪🧬🖥️
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eppro02.ativ.me
November 6, 2024 at 12:24 AM
Now: Rajiv McCoy: Genetic architecture of meiotic recombination across 90,431 in vitro fertilized embryos #ASHG24 🧪🧬🖥️