Stacey Kigar
@staceykigar.bsky.social
Research Associate, University of Cambridge | Leading Edge fellow | first-gen academic | molecular biologist studying effects of stress across the lifespan 🧠🩸🧬
This work is an important first step toward refining psychiatric diagnoses, aligning them with biological processes, and empowering discovery of new treatment options.
November 28, 2025 at 2:09 PM
This work is an important first step toward refining psychiatric diagnoses, aligning them with biological processes, and empowering discovery of new treatment options.
i.e., anxious-depression, social withdrawal, compulsivity & intrusive thought - and the levels of different immune cells and plasma cytokines. These relationships varied with and without exposure to stress. Exposing white blood cells to an immune challenge revealed further symptom relationships
November 28, 2025 at 2:07 PM
i.e., anxious-depression, social withdrawal, compulsivity & intrusive thought - and the levels of different immune cells and plasma cytokines. These relationships varied with and without exposure to stress. Exposing white blood cells to an immune challenge revealed further symptom relationships
laying the groundwork to reveal common biological processes & to enable future therapeutic options. We used a laboratory-induced stressor, immunophenotyping, and comprehensive cognitive testing to profile healthy volunteers. We find relationships between transdiagnostic symptoms...
November 28, 2025 at 1:59 PM
laying the groundwork to reveal common biological processes & to enable future therapeutic options. We used a laboratory-induced stressor, immunophenotyping, and comprehensive cognitive testing to profile healthy volunteers. We find relationships between transdiagnostic symptoms...
“balanced on a toothpick labelled DNS” - @scalarmoon.bsky.social
November 18, 2025 at 10:04 PM
“balanced on a toothpick labelled DNS” - @scalarmoon.bsky.social
Thank you! That is certainly the hope, though there’s much work ahead re: translating these results from rodent to human.
October 1, 2025 at 7:55 PM
Thank you! That is certainly the hope, though there’s much work ahead re: translating these results from rodent to human.
I am so grateful to everyone involved in bringing this paper to fruition, and am especially grateful to the NIH and @cambridgebrc.bsky.social for supporting me throughout. To read a summary of the project, please check out this summary by Craig Brierley here: www.cam.ac.uk/research/new...
Depression linked to presence of immune cells in the brain’s protective layer
Immune cells released from bone marrow in the skull in response to chronic stress and adversity could play a key role in symptoms of depression and anxiety,
www.cam.ac.uk
September 1, 2025 at 11:08 AM
I am so grateful to everyone involved in bringing this paper to fruition, and am especially grateful to the NIH and @cambridgebrc.bsky.social for supporting me throughout. To read a summary of the project, please check out this summary by Craig Brierley here: www.cam.ac.uk/research/new...
It involved lots of hard work from my brilliant co-authors, including co-first author @maryellenlynall.bsky.social and others who as far as I know aren’t on blue sky. Data collection took place during Covid lockdown, and involved coordinating teams transatlantically, requiring lots of grit/tenacity!
September 1, 2025 at 11:03 AM
It involved lots of hard work from my brilliant co-authors, including co-first author @maryellenlynall.bsky.social and others who as far as I know aren’t on blue sky. Data collection took place during Covid lockdown, and involved coordinating teams transatlantically, requiring lots of grit/tenacity!
Systemic depletion of type I interferon signaling improved depressive behavior in chronically stressed mice, and may hold promise as a future target for depression treatment. This project was a labor of love, stemming from work done many years ago now while I was still a postdoc at the NIH campus…
September 1, 2025 at 10:56 AM
Systemic depletion of type I interferon signaling improved depressive behavior in chronically stressed mice, and may hold promise as a future target for depression treatment. This project was a labor of love, stemming from work done many years ago now while I was still a postdoc at the NIH campus…
A unique population of neutrophils that are regulated independently of neutrophils derived from other bone marrow stores, like tibia. Our single cell RNA sequencing analysis of meningeal tissue showed type I interferons as a plausible candidate triggering movement of neutrophils into the meninges…
September 1, 2025 at 10:51 AM
A unique population of neutrophils that are regulated independently of neutrophils derived from other bone marrow stores, like tibia. Our single cell RNA sequencing analysis of meningeal tissue showed type I interferons as a plausible candidate triggering movement of neutrophils into the meninges…