Tadasu Nozaki
@tadasu443.bsky.social
Chromosome researcher at Harvard University
#LiveCell #SingleMolecule #Meiosis #Chromatin #pairing
https://scholar.google.com/citations?user=us0AM-wAAAAJ&hl=en
#LiveCell #SingleMolecule #Meiosis #Chromatin #pairing
https://scholar.google.com/citations?user=us0AM-wAAAAJ&hl=en
Reposted by Tadasu Nozaki
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 5, 2025 at 7:46 AM
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
Reposted by Tadasu Nozaki
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Reposted by Tadasu Nozaki
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Tadasu Nozaki
Chromosome Dynamics 2026 @ Awaji Japan www.fbs.osaka-u.ac.jp/labs/fukagaw...
November 21, 2025 at 11:09 AM
Chromosome Dynamics 2026 @ Awaji Japan www.fbs.osaka-u.ac.jp/labs/fukagaw...
I launched my lab at UMass Amherst this fall. We study the mechanisms of meiotic homolog pairing using advanced live‑cell and super‑resolution imaging. Currently in budding yeast, with plans to expand to other eukaryotes. #Chromosome #Meiosis #Mitosis
www.umass.edu/biology/abou...
www.umass.edu/biology/abou...
November 13, 2025 at 12:13 PM
I launched my lab at UMass Amherst this fall. We study the mechanisms of meiotic homolog pairing using advanced live‑cell and super‑resolution imaging. Currently in budding yeast, with plans to expand to other eukaryotes. #Chromosome #Meiosis #Mitosis
www.umass.edu/biology/abou...
www.umass.edu/biology/abou...
Reposted by Tadasu Nozaki
Reposted by Tadasu Nozaki
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Tadasu Nozaki
Dynamic chromosomes
May 30, 2025 at 7:12 PM
Dynamic chromosomes
Reposted by Tadasu Nozaki
In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Saccharomycopsis yichangensis sp. nov., a Novel Predacious Yeast Species Isolated From Soil
Saccharomycopsis yichangensis sp. nov. occurs in soil from a subtropical forest in central China. This novel species is homothallic and produces asci containing four spheroidal ascospores, which can ...
onlinelibrary.wiley.com
May 22, 2025 at 9:21 AM
In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Tadasu Nozaki
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
May 5, 2025 at 7:22 AM
Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!
Reposted by Tadasu Nozaki
🧬My retrospective chromatin review is out @Proc Jpn Acad:
doi.org/10.2183/pjab...
The textbook view of #chromatin as 30-nm fibers is fading.
A new paradigm: chromatin forms #liquid-like domains—locally dynamic, yet globally stable at the chromosome level (viscoelastic)—supporting genome function. ✨
doi.org/10.2183/pjab...
The textbook view of #chromatin as 30-nm fibers is fading.
A new paradigm: chromatin forms #liquid-like domains—locally dynamic, yet globally stable at the chromosome level (viscoelastic)—supporting genome function. ✨
April 25, 2025 at 12:24 AM
🧬My retrospective chromatin review is out @Proc Jpn Acad:
doi.org/10.2183/pjab...
The textbook view of #chromatin as 30-nm fibers is fading.
A new paradigm: chromatin forms #liquid-like domains—locally dynamic, yet globally stable at the chromosome level (viscoelastic)—supporting genome function. ✨
doi.org/10.2183/pjab...
The textbook view of #chromatin as 30-nm fibers is fading.
A new paradigm: chromatin forms #liquid-like domains—locally dynamic, yet globally stable at the chromosome level (viscoelastic)—supporting genome function. ✨
Reposted by Tadasu Nozaki
A blutorial on my latest manuscript, which will appear as a Hypothesis article in Journal of Cell Science (no embargo requested as far as I am aware). If you are interested in mitosis/meiosis/kinetochores/evolution/deep phylogeny, please read it (1/n)
April 27, 2025 at 2:19 PM
A blutorial on my latest manuscript, which will appear as a Hypothesis article in Journal of Cell Science (no embargo requested as far as I am aware). If you are interested in mitosis/meiosis/kinetochores/evolution/deep phylogeny, please read it (1/n)
Reposted by Tadasu Nozaki
New open access review from Jon Harper and George Brown—charting the evolutionary history of Spo11 and its regulation.
portlandpress.com/biochemsoctr... #meiosis4eva
portlandpress.com/biochemsoctr... #meiosis4eva
Spo11: from topoisomerase VI to meiotic recombination initiator
Meiotic recombination is required to break up gene linkage and facilitate faithful chromosome segregation during gamete formation. By inducing DNA double-strand breaks, Spo11, a protein that is conser...
portlandpress.com
April 22, 2025 at 8:40 AM
New open access review from Jon Harper and George Brown—charting the evolutionary history of Spo11 and its regulation.
portlandpress.com/biochemsoctr... #meiosis4eva
portlandpress.com/biochemsoctr... #meiosis4eva
Reposted by Tadasu Nozaki
I’m pleased to announce that I have now officially started my research group at the University of Dundee, UK. My laboratory focus on how transcription factors orchestrate epigenetic reprogramming in mammalian embryos.
April 22, 2025 at 3:09 PM
I’m pleased to announce that I have now officially started my research group at the University of Dundee, UK. My laboratory focus on how transcription factors orchestrate epigenetic reprogramming in mammalian embryos.
Reposted by Tadasu Nozaki
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 4:06 PM
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Reposted by Tadasu Nozaki
James M. Berger will Deliver the Paul Doty Lecture on April 10
www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social @rivaselenarivas.bsky.social @fleshball.bsky.social @jeeyunc.bsky.social @hekstralab.bsky.social
www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social @rivaselenarivas.bsky.social @fleshball.bsky.social @jeeyunc.bsky.social @hekstralab.bsky.social
James Berger will Deliver the Paul Doty Lecture on April 10 - Harvard University - Department of Molecular & Cellular Biology
This year, James M Berger, of Johns Hopkins University School of Medicine will return to Harvard to present the Doty Lecture, “Still Unscrambling the Puzzle of Biological Machines: […]
www.mcb.harvard.edu
March 31, 2025 at 3:08 PM
James M. Berger will Deliver the Paul Doty Lecture on April 10
www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social @rivaselenarivas.bsky.social @fleshball.bsky.social @jeeyunc.bsky.social @hekstralab.bsky.social
www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social @rivaselenarivas.bsky.social @fleshball.bsky.social @jeeyunc.bsky.social @hekstralab.bsky.social
Reposted by Tadasu Nozaki
(1/2) Glad to inform that our work is finally out from Science Advances!
Our Repli-Histo labeling revealed the distinct physical properties of euchromatin (liquid-like) and heterochromatin (gel-like) and their implications for replication timing.
Our Repli-Histo labeling revealed the distinct physical properties of euchromatin (liquid-like) and heterochromatin (gel-like) and their implications for replication timing.
Our new paper is out@ScienceAdvances👇
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
April 1, 2025 at 12:11 PM
(1/2) Glad to inform that our work is finally out from Science Advances!
Our Repli-Histo labeling revealed the distinct physical properties of euchromatin (liquid-like) and heterochromatin (gel-like) and their implications for replication timing.
Our Repli-Histo labeling revealed the distinct physical properties of euchromatin (liquid-like) and heterochromatin (gel-like) and their implications for replication timing.
Reposted by Tadasu Nozaki
Our new paper is out@ScienceAdvances👇
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
March 29, 2025 at 1:06 AM
Our new paper is out@ScienceAdvances👇
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
Reposted by Tadasu Nozaki
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
March 25, 2025 at 4:00 PM
Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...
Reposted by Tadasu Nozaki
Countdown to an epic new pre-print.
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
March 25, 2025 at 10:35 AM
Countdown to an epic new pre-print.
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!
Reposted by Tadasu Nozaki
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
March 24, 2025 at 3:29 PM
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Reposted by Tadasu Nozaki
There are ~180 chromosomes in this diplonemid, which organize into two rings during mitosis. Chromosomal passenger complex proteins localize in between the rings. Indirect evidence suggests that the cell is in metaphase but the two rings are separated by up to 1 µm. How are they connected?
March 24, 2025 at 3:28 PM
There are ~180 chromosomes in this diplonemid, which organize into two rings during mitosis. Chromosomal passenger complex proteins localize in between the rings. Indirect evidence suggests that the cell is in metaphase but the two rings are separated by up to 1 µm. How are they connected?
Reposted by Tadasu Nozaki
I am happy to share a preprint on the marine plankton project I started one year ago (thanks to Julius and Drahomira's help)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 24, 2025 at 3:22 PM
I am happy to share a preprint on the marine plankton project I started one year ago (thanks to Julius and Drahomira's help)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tadasu Nozaki
Happy that Jon Chen @jonchenjk.bsky.social's cryo-ET and confocal study of RPE-1 chromatin in situ is online www.embopress.org/doi/full/10.1038/s44318-025-00407-2
Congrats also to coauthors Tingsheng Liu, @shujuncai.bsky.social, Cai Tong Ng, Jian Shi and collaborators Weimei Ruan Uttam Surana.
Congrats also to coauthors Tingsheng Liu, @shujuncai.bsky.social, Cai Tong Ng, Jian Shi and collaborators Weimei Ruan Uttam Surana.
March 17, 2025 at 9:36 PM
Happy that Jon Chen @jonchenjk.bsky.social's cryo-ET and confocal study of RPE-1 chromatin in situ is online www.embopress.org/doi/full/10.1038/s44318-025-00407-2
Congrats also to coauthors Tingsheng Liu, @shujuncai.bsky.social, Cai Tong Ng, Jian Shi and collaborators Weimei Ruan Uttam Surana.
Congrats also to coauthors Tingsheng Liu, @shujuncai.bsky.social, Cai Tong Ng, Jian Shi and collaborators Weimei Ruan Uttam Surana.