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thelahalab.bsky.social
Debabrata Laha
@thelahalab.bsky.social
34 followers 62 following 4 posts
Assistant Professor, Department of Biochemistry, Indian Institute of Science, Bangalore. Molecular Plant Physiology, Inositol Phosphate Biology, Cell Signalling. Former @ZMBP Tuebingen, @LMCB UCL
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thelahalab.bsky.social
Debabrata Laha @thelahalab.bsky.social · Jul 31
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com

www.nature.com/articles/s41...
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology
A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...
www.nature.com
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thelahalab.bsky.social
Debabrata Laha @thelahalab.bsky.social · 28d
We are grateful to the editor and reviewers for their critical and constructive feedback that strengthened our conclusion.
thelahalab.bsky.social
Debabrata Laha @thelahalab.bsky.social · 28d
Happy to share our work on identification of non-archetypal activity of IPK2 in producing inositol pyrophosphate 4/6-IP7 and regulating heat stress acclimation-conserved in studied land plants. Grateful to @jessenlab.bsky.social for wonderful collaborative efforts!

journals.plos.org/plosgenetics...
Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants
Author summary Inositol pyrophosphates (PP-InsPs) are eukaryote-specific cellular messengers that control a plethora of critical physiological processes, ranging from cellular metabolism to cellular e...
journals.plos.org
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thelahalab.bsky.social
Debabrata Laha @thelahalab.bsky.social · Jul 31
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com

www.nature.com/articles/s41...
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology
A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...
www.nature.com
2 7
Reposted by Debabrata Laha
jessenlab.bsky.social
Henning Jessen @jessenlab.bsky.social · Jul 1
congrats to Kevin! His paper on new inositol pyrophosphates is out in @angewandtechemie.bsky.social

doi.org/10.1002/anie...
Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despit...
doi.org
2 2 10
thelahalab.bsky.social
Debabrata Laha @thelahalab.bsky.social · Jul 1
Congratulations Henning, Kevin, Gabriel and team!
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Reposted by Debabrata Laha
jessenlab.bsky.social
Henning Jessen @jessenlab.bsky.social · Apr 18
An alternative strategy to access inositol derivatives by stereoselective dephosphorylation. Happy to share the work by Markus Haener together with @gabrielschaaf.bsky.social and many others.
chemrxiv.org/engage/chemr...
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Phosphorylated myo-inositols (InsPs) are essential cytoplasmic signaling molecules, while their lipidated analogs (PtdInsPs) play a crucial role in membrane signaling. Stereoselective synthesis of the...
chemrxiv.org
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Reposted by Debabrata Laha
grandpahiro.bsky.social
Hiro Nakagami @grandpahiro.bsky.social · Apr 17
The final version of our study on SERK-BIR module in Marchantia is out.

Congratulations Cate and many thanks to collaborators!

www.sciencedirect.com/science/arti...
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Reposted by Debabrata Laha
jessenlab.bsky.social
Henning Jessen @jessenlab.bsky.social · Mar 28
Happy to share Kevin´s great work on PP-InsP4 synthesis and analysis now available on Chemrxiv!

chemrxiv.org/engage/chemr...
Expanding the PP-INSP₄ Toolbox: Synthesis, Stereochemical Assignment, and Application in Plant Phosphate Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite...
chemrxiv.org
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