The Menachery Lab
@themenacherylab.bsky.social
A coronavirus lab looking for low hanging pebbles and shiny fruit.
Emory University
Emory University
Results show #SARS2 uses NSP3 at early times to limit SG formation.
Our prior work with N shows antagonism of SGs at late times pubmed.ncbi.nlm.nih.gov/38492217
Coupled with reported anti-SG activities in NSP1 & NSP5, the results show SARS2 invests significant genetic capital in controlling SGs
Our prior work with N shows antagonism of SGs at late times pubmed.ncbi.nlm.nih.gov/38492217
Coupled with reported anti-SG activities in NSP1 & NSP5, the results show SARS2 invests significant genetic capital in controlling SGs
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity - PubMed
G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress granule assembly and interacts with G3BP1/2 via an ITFG moti …
pubmed.ncbi.nlm.nih.gov
November 25, 2025 at 12:57 PM
Results show #SARS2 uses NSP3 at early times to limit SG formation.
Our prior work with N shows antagonism of SGs at late times pubmed.ncbi.nlm.nih.gov/38492217
Coupled with reported anti-SG activities in NSP1 & NSP5, the results show SARS2 invests significant genetic capital in controlling SGs
Our prior work with N shows antagonism of SGs at late times pubmed.ncbi.nlm.nih.gov/38492217
Coupled with reported anti-SG activities in NSP1 & NSP5, the results show SARS2 invests significant genetic capital in controlling SGs
Our work shows disruption of Y138/F145 disrupts FXR1 binding and attenuates infection both in vitro and in vivo.
Importantly, the NSP3 mutant has no augmentation of type I IFN responses, but is unable to control SG formation after infection and inductions by arsenite.
Importantly, the NSP3 mutant has no augmentation of type I IFN responses, but is unable to control SG formation after infection and inductions by arsenite.
November 25, 2025 at 12:57 PM
Our work shows disruption of Y138/F145 disrupts FXR1 binding and attenuates infection both in vitro and in vivo.
Importantly, the NSP3 mutant has no augmentation of type I IFN responses, but is unable to control SG formation after infection and inductions by arsenite.
Importantly, the NSP3 mutant has no augmentation of type I IFN responses, but is unable to control SG formation after infection and inductions by arsenite.
This advice is what has worked for me at #ASV2023 meetings in the past.
It may not work for you, but hopefully gives you some thoughts on how to approach networking.
It may not work for you, but hopefully gives you some thoughts on how to approach networking.
July 14, 2025 at 6:50 PM
This advice is what has worked for me at #ASV2023 meetings in the past.
It may not work for you, but hopefully gives you some thoughts on how to approach networking.
It may not work for you, but hopefully gives you some thoughts on how to approach networking.
Last bit of advice: Trust your gut.
You won’t connect with some people. Maybe they aren’t a good fit or make you feel uncomfortable.
Don’t stay engaged cause they are in an important lab or are part of a cool club.
These interactions are often paths to toxicity. Beware…
You won’t connect with some people. Maybe they aren’t a good fit or make you feel uncomfortable.
Don’t stay engaged cause they are in an important lab or are part of a cool club.
These interactions are often paths to toxicity. Beware…
July 14, 2025 at 6:50 PM
Last bit of advice: Trust your gut.
You won’t connect with some people. Maybe they aren’t a good fit or make you feel uncomfortable.
Don’t stay engaged cause they are in an important lab or are part of a cool club.
These interactions are often paths to toxicity. Beware…
You won’t connect with some people. Maybe they aren’t a good fit or make you feel uncomfortable.
Don’t stay engaged cause they are in an important lab or are part of a cool club.
These interactions are often paths to toxicity. Beware…
Once you start in a group bring others in.
Maybe people from your university or the guy you met on the bus. Whoever.
Grow the group you interact with. It will help everyone network.
Maybe people from your university or the guy you met on the bus. Whoever.
Grow the group you interact with. It will help everyone network.
July 14, 2025 at 6:50 PM
Once you start in a group bring others in.
Maybe people from your university or the guy you met on the bus. Whoever.
Grow the group you interact with. It will help everyone network.
Maybe people from your university or the guy you met on the bus. Whoever.
Grow the group you interact with. It will help everyone network.
At one #ASV I glommed onto
Tim Sheahan
&
@christopherbrooke.bsky.social
having met them at a UNC grad school interview years earlier ( I didn’t get in).
I hung out with UNC people that meeting and thereafter and paved my way to a postdoc there years later.
Tim Sheahan
&
@christopherbrooke.bsky.social
having met them at a UNC grad school interview years earlier ( I didn’t get in).
I hung out with UNC people that meeting and thereafter and paved my way to a postdoc there years later.
July 14, 2025 at 6:50 PM
At one #ASV I glommed onto
Tim Sheahan
&
@christopherbrooke.bsky.social
having met them at a UNC grad school interview years earlier ( I didn’t get in).
I hung out with UNC people that meeting and thereafter and paved my way to a postdoc there years later.
Tim Sheahan
&
@christopherbrooke.bsky.social
having met them at a UNC grad school interview years earlier ( I didn’t get in).
I hung out with UNC people that meeting and thereafter and paved my way to a postdoc there years later.
“But I don’t know anyone at #ASV2023”
Advice 5: Find a group of people. Students from your lab, university are a good start. Friendships in lab are often started at conferences through shared experiences.
From there you can go to groups like #binningvirologists & other groups
Advice 5: Find a group of people. Students from your lab, university are a good start. Friendships in lab are often started at conferences through shared experiences.
From there you can go to groups like #binningvirologists & other groups
July 14, 2025 at 6:50 PM
“But I don’t know anyone at #ASV2023”
Advice 5: Find a group of people. Students from your lab, university are a good start. Friendships in lab are often started at conferences through shared experiences.
From there you can go to groups like #binningvirologists & other groups
Advice 5: Find a group of people. Students from your lab, university are a good start. Friendships in lab are often started at conferences through shared experiences.
From there you can go to groups like #binningvirologists & other groups
Advice 4: careful approaching groups of faculty to chat.
We were all once trainees. When we are together, we talk science. We also gossip and talk smack. Most of us don’t do that in front of trainees.
Be aware of what your interrupting. Read the signals. It’s ok, but be cool.
We were all once trainees. When we are together, we talk science. We also gossip and talk smack. Most of us don’t do that in front of trainees.
Be aware of what your interrupting. Read the signals. It’s ok, but be cool.
July 14, 2025 at 6:50 PM
Advice 4: careful approaching groups of faculty to chat.
We were all once trainees. When we are together, we talk science. We also gossip and talk smack. Most of us don’t do that in front of trainees.
Be aware of what your interrupting. Read the signals. It’s ok, but be cool.
We were all once trainees. When we are together, we talk science. We also gossip and talk smack. Most of us don’t do that in front of trainees.
Be aware of what your interrupting. Read the signals. It’s ok, but be cool.
Personally I take an intro more seriously as the person introducing vouches for you.
Also I will get more info from them later so make sure your contact will be truthful and supportive (in that order for me).
Also I will get more info from them later so make sure your contact will be truthful and supportive (in that order for me).
July 14, 2025 at 6:50 PM
Personally I take an intro more seriously as the person introducing vouches for you.
Also I will get more info from them later so make sure your contact will be truthful and supportive (in that order for me).
Also I will get more info from them later so make sure your contact will be truthful and supportive (in that order for me).