The Tidgewell Research Lab
@thetidgelab.bsky.social
Drug Discovery Lab at the University of Kentucky College of Pharmacy
We do natural products discovery and medicinal chemistry synthesis to develop new compounds to treat and understand CNS disorders
Account ran by KJT
We do natural products discovery and medicinal chemistry synthesis to develop new compounds to treat and understand CNS disorders
Account ran by KJT
Great 4th year seminar by one of the grad students working in the lab this morning!! Be on the lookout for some of her work to make it to publication in 2026 hopefully 🤠
November 18, 2025 at 4:47 PM
Great 4th year seminar by one of the grad students working in the lab this morning!! Be on the lookout for some of her work to make it to publication in 2026 hopefully 🤠
Really excited about this paper going live this mornning!!
Lots of hard work by a great team and should be more to come
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization Journal of Natural Products pubs.acs.org/doi/full/10....
Lots of hard work by a great team and should be more to come
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization Journal of Natural Products pubs.acs.org/doi/full/10....
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization
The human sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97) has been identified as a promising target to modulate neuronal excitability in chronic pain and address the unmet need for nonopioid th...
pubs.acs.org
November 6, 2025 at 2:38 PM
Really excited about this paper going live this mornning!!
Lots of hard work by a great team and should be more to come
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization Journal of Natural Products pubs.acs.org/doi/full/10....
Lots of hard work by a great team and should be more to come
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization Journal of Natural Products pubs.acs.org/doi/full/10....
Reposted by The Tidgewell Research Lab
The Department of Biology at the University of Kentucky is hiring a Microbiologist (broadly defined). Microbial eco-evo folks, this is your sign to come work with us. Not in the search committee, but happy to answer questions.
ukjobs.uky.edu/postings/600...
#microbiology #ecology
ukjobs.uky.edu/postings/600...
#microbiology #ecology
Assistant or Associate Professor in Microbiology
The Department of Biology in the College of Arts and Sciences at the University of Kentucky in Lexington, KY seeks to fill a tenure-eligible faculty position at the Assistant or Associate Professor le...
ukjobs.uky.edu
October 1, 2025 at 3:20 PM
The Department of Biology at the University of Kentucky is hiring a Microbiologist (broadly defined). Microbial eco-evo folks, this is your sign to come work with us. Not in the search committee, but happy to answer questions.
ukjobs.uky.edu/postings/600...
#microbiology #ecology
ukjobs.uky.edu/postings/600...
#microbiology #ecology
Fun to start the day off today with a departmental seminar by one of the grad students in the lab.
September 30, 2025 at 3:11 PM
Fun to start the day off today with a departmental seminar by one of the grad students in the lab.
Back in New Hampshire for some fun at the GRC Bioactives and Natural Products!! Stoked for a week of science and walking in the woods and more science
July 27, 2025 at 7:11 PM
Back in New Hampshire for some fun at the GRC Bioactives and Natural Products!! Stoked for a week of science and walking in the woods and more science
So I was doing some account balancing today and just noticed the Sigma is adding a "Tarriff" Charge onto our most recent orders ... anyone else notice that? #chemsky
July 17, 2025 at 3:47 PM
So I was doing some account balancing today and just noticed the Sigma is adding a "Tarriff" Charge onto our most recent orders ... anyone else notice that? #chemsky
Reposted by The Tidgewell Research Lab
A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.
The importance of feeling responsibility and taking pride in doing the best job you can
The importance of feeling responsibility and taking pride in doing the best job you can
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
July 6, 2025 at 11:28 AM
A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.
The importance of feeling responsibility and taking pride in doing the best job you can
The importance of feeling responsibility and taking pride in doing the best job you can
Reposted by The Tidgewell Research Lab
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
July 6, 2025 at 3:13 PM
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by The Tidgewell Research Lab
Lab earned a gold star today! Way to go team, keep up the hard work
@ukresearch.bsky.social
@ukresearch.bsky.social
June 25, 2025 at 6:28 PM
Lab earned a gold star today! Way to go team, keep up the hard work
@ukresearch.bsky.social
@ukresearch.bsky.social
Reposted by The Tidgewell Research Lab
Here is the dirty secret no one is speaking out loud: Trump does not believe that bombing the hell out of Iran is going to send Iran back to the negotiation table, nor has anyone in his inner circle suggested to him that outcome.
He fully knows he has entered America into a war.
He fully knows he has entered America into a war.
June 22, 2025 at 7:39 AM
Here is the dirty secret no one is speaking out loud: Trump does not believe that bombing the hell out of Iran is going to send Iran back to the negotiation table, nor has anyone in his inner circle suggested to him that outcome.
He fully knows he has entered America into a war.
He fully knows he has entered America into a war.
Reposted by The Tidgewell Research Lab
U.S. Rep Thomas Massie (R-KY) declared Saturday evening that his party's leader, the president of the United States, made an unconstitutional move.
'This is not Constitutional': GOP congressman stands up to Trump on Iran strike
U.S. Rep Thomas Massie (R-KY) declared Saturday evening that his party's leader, the president of the United States, made an unconstitutional move.Trump over the weekend announced his administration had dropped a "full payload of bombs" on Iran."We have completed our very successful attack on the th...
bit.ly
June 22, 2025 at 12:55 AM
U.S. Rep Thomas Massie (R-KY) declared Saturday evening that his party's leader, the president of the United States, made an unconstitutional move.
Reposted by The Tidgewell Research Lab
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 3:01 PM
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Group Photo Day!
@ukresearch.bsky.social
@ukresearch.bsky.social
May 2, 2025 at 4:53 PM
Group Photo Day!
@ukresearch.bsky.social
@ukresearch.bsky.social
Reposted by The Tidgewell Research Lab
Research drives discovery at UK.
Funding from the NIH makes a difference. UK Acting Vice President for Research Ilhem Messaoudi explains how this funding impacts Kentuckians.
Learn more: www.research.uky.edu/news/researc...
Funding from the NIH makes a difference. UK Acting Vice President for Research Ilhem Messaoudi explains how this funding impacts Kentuckians.
Learn more: www.research.uky.edu/news/researc...
April 28, 2025 at 3:24 PM
Research drives discovery at UK.
Funding from the NIH makes a difference. UK Acting Vice President for Research Ilhem Messaoudi explains how this funding impacts Kentuckians.
Learn more: www.research.uky.edu/news/researc...
Funding from the NIH makes a difference. UK Acting Vice President for Research Ilhem Messaoudi explains how this funding impacts Kentuckians.
Learn more: www.research.uky.edu/news/researc...
Reposted by The Tidgewell Research Lab
Some important additional considerations about the need to comment of the implementation of schedule F.
First, several sources have indicated that Institute Director and Division Director positions would likely be converted but not Program Officers.
1/n
First, several sources have indicated that Institute Director and Division Director positions would likely be converted but not Program Officers.
1/n
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23.
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
www.federalregister.gov
April 26, 2025 at 10:22 PM
Some important additional considerations about the need to comment of the implementation of schedule F.
First, several sources have indicated that Institute Director and Division Director positions would likely be converted but not Program Officers.
1/n
First, several sources have indicated that Institute Director and Division Director positions would likely be converted but not Program Officers.
1/n
This is heartbreaking and terrifying
April 21, 2025 at 9:13 PM
This is heartbreaking and terrifying
Really fun visit to @ucsantacruz.bsky.social for a seminar
Huge thanks to @drlaurasanchez.bsky.social for the invite
Tried my best to channel banana slugs and was rewarded with a couple along the walk in 😁
Huge thanks to @drlaurasanchez.bsky.social for the invite
Tried my best to channel banana slugs and was rewarded with a couple along the walk in 😁
April 8, 2025 at 7:03 PM
Really fun visit to @ucsantacruz.bsky.social for a seminar
Huge thanks to @drlaurasanchez.bsky.social for the invite
Tried my best to channel banana slugs and was rewarded with a couple along the walk in 😁
Huge thanks to @drlaurasanchez.bsky.social for the invite
Tried my best to channel banana slugs and was rewarded with a couple along the walk in 😁
Reposted by The Tidgewell Research Lab
Somehow you knew this was coming.
They will do anything to avoid responding meaningfully to FOIA requests.
They will do anything to avoid responding meaningfully to FOIA requests.
Waltz and staff used Gmail for government communications, officials say
Trump’s national security adviser is trying to manage his way out of a crisis. But new revelations about his team’s operational security are piling up in the inbox.
www.washingtonpost.com
April 1, 2025 at 10:42 PM
Somehow you knew this was coming.
They will do anything to avoid responding meaningfully to FOIA requests.
They will do anything to avoid responding meaningfully to FOIA requests.
Reposted by The Tidgewell Research Lab
See this chart for one stark example: NIH funding has dramatically slowed down.
Grant awards are down *$3 billion* so far, compared to same time period last year
I asked the White House to explain.
“This is not a researcher entitlement program,” said an official, defending their new approach.
Grant awards are down *$3 billion* so far, compared to same time period last year
I asked the White House to explain.
“This is not a researcher entitlement program,” said an official, defending their new approach.
March 28, 2025 at 1:13 PM
See this chart for one stark example: NIH funding has dramatically slowed down.
Grant awards are down *$3 billion* so far, compared to same time period last year
I asked the White House to explain.
“This is not a researcher entitlement program,” said an official, defending their new approach.
Grant awards are down *$3 billion* so far, compared to same time period last year
I asked the White House to explain.
“This is not a researcher entitlement program,” said an official, defending their new approach.
Awesome visit to @utah.edu for a seminar in the Pharm Tox Department
Lots of great neuroscience focused chats and great group of faculty plus snuck out to see a bit of nature as well
Lots of great neuroscience focused chats and great group of faculty plus snuck out to see a bit of nature as well
March 24, 2025 at 4:34 AM
Awesome visit to @utah.edu for a seminar in the Pharm Tox Department
Lots of great neuroscience focused chats and great group of faculty plus snuck out to see a bit of nature as well
Lots of great neuroscience focused chats and great group of faculty plus snuck out to see a bit of nature as well
Another fun international collaboration (that started via email) resulting in a publication out today!
Happy to be a small part of this awesome chemistry effort by the groups at Uni Bristol
Happy to be a small part of this awesome chemistry effort by the groups at Uni Bristol
Now online & open access:
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A - Nature Synthesis
The structures of 1,5-polyol-containing polyketide-derived natural products are notoriously difficult to determine using spectroscopic techniques due to spectral overlap and chemical shift degeneracy....
www.nature.com
March 13, 2025 at 1:26 PM
Another fun international collaboration (that started via email) resulting in a publication out today!
Happy to be a small part of this awesome chemistry effort by the groups at Uni Bristol
Happy to be a small part of this awesome chemistry effort by the groups at Uni Bristol
Reposted by The Tidgewell Research Lab
All of the physics knowledge in the world and all of the paper published about NASA’s success and failures won’t save you if you fired the seamstress who knew the one weird trick to the stitches on a blanket or a parachute.
Not all knowledge is translated well by text. (2/)
Not all knowledge is translated well by text. (2/)
March 7, 2025 at 11:07 PM
All of the physics knowledge in the world and all of the paper published about NASA’s success and failures won’t save you if you fired the seamstress who knew the one weird trick to the stitches on a blanket or a parachute.
Not all knowledge is translated well by text. (2/)
Not all knowledge is translated well by text. (2/)
New paper with my collaborator in Cameroon exploring the utility of traditionally used plants as therapeutics and for discovering new leads for development. Check it out!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Aqueous and Ethanol Extracts of Acacia sieberiana (Fabaceae) Stem Bark Reverse the Pain–Depression Dyad in Mice Through Modulation of Catecholamines, Proinflammatory Cytokines, and Oxidative Stress
Rationale and Objective: The pain–depression dyad is highly prevalent and has reciprocal psychological and behavioral effects, leading to poor quality of life, increased disability, and challenging t...
onlinelibrary.wiley.com
March 6, 2025 at 2:00 PM
New paper with my collaborator in Cameroon exploring the utility of traditionally used plants as therapeutics and for discovering new leads for development. Check it out!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....