The Tidgewell Research Lab
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thetidgelab.bsky.social
The Tidgewell Research Lab
@thetidgelab.bsky.social
Drug Discovery Lab at the University of Kentucky College of Pharmacy
We do natural products discovery and medicinal chemistry synthesis to develop new compounds to treat and understand CNS disorders
Account ran by KJT
My new favorite one are www.nature.com/articles/s41... and bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

So Yoda1 is the compound that actives Piezo channels and Dooku1 blocks them!!

Piezo channels are ... wait for it ... Force channels
#maythe4thbewithyou
May 5, 2025 at 2:38 AM
Reposted by The Tidgewell Research Lab
See this chart for one stark example: NIH funding has dramatically slowed down.

Grant awards are down *$3 billion* so far, compared to same time period last year

I asked the White House to explain.

“This is not a researcher entitlement program,” said an official, defending their new approach.
March 28, 2025 at 1:13 PM
Reposted by The Tidgewell Research Lab
All of the physics knowledge in the world and all of the paper published about NASA’s success and failures won’t save you if you fired the seamstress who knew the one weird trick to the stitches on a blanket or a parachute.

Not all knowledge is translated well by text. (2/)
March 7, 2025 at 11:07 PM