Lightnews — Scholar-powered news

Thomas Jaki @thomasjaki.bsky.social · Jun 23

Incorporating historic information to further improve power when conducting Bayesian information borrowing in basket trials

academic.oup.com/biostatistic...

Incorporating historic information to further improve power when conducting Bayesian information borrowing in basket trials

ABSTRACT. In basket trials a single therapeutic treatment is tested on several patient populations simultaneously, each of which forming a basket, where pa

academic.oup.com

Thomas Jaki @thomasjaki.bsky.social · Jun 23

Design of platform trials with a change in the control treatment arm

academic.oup.com/biometrics/a...

Design of platform trials with a change in the control treatment arm

ABSTRACT. Platform trials are an efficient way of testing multiple treatments. We consider platform trials where, if a treatment is found to be superior to

academic.oup.com

2 2

Reposted by Thomas Jaki

MRC Biostatistics Unit @mrc-bsu.bsky.social · Jun 6

Fantastic two days of stimulating talks and discussions at our Workshop on Adaptive and Bayesian Designs in Real Trials, where statisticians, clinicians and patients have shared their experiences of #ClinicalTrials.

Thanks to all our speakers and all those who attended.

Photo of speakers from day 1, all smiling and looking at camera.

Photo of speaker, Christina Yap, giving talk.

Photo of speakers of day 2, all smiling and looking at camera.

Photo of Pavel Mozgunov delivering talk.

1 1 1

Thomas Jaki @thomasjaki.bsky.social · Apr 25

A thought provoking event. Glad I could participate.

MRC Biostatistics Unit @mrc-bsu.bsky.social · Apr 24

Our Ethics and Innovative Trial Designs Workshop has kicked off with @thomasjaki.bsky.social speaking on routinely used and complex adaptive designs.

2

Reposted by Thomas Jaki

MRC Biostatistics Unit @mrc-bsu.bsky.social · Feb 27

(1/2) Another action packed day at the workshop on Adaptive Designs and Multiple Testing Procedures in Regensburg, with great talks from BSU researchers and PhD students - Gianmarco Caruso, Stef Baas and James Willard.

Photo of Stef Baas giving talk, with presentation screen behind him.

Photo of Gianmarco Caruso giving talk, with presentation screen behind him.

Photo of James Willard giving talk, with presentation screen behind him.

1 1 2

Reposted by Thomas Jaki

MRC Biostatistics Unit @mrc-bsu.bsky.social · Feb 26

David Robertson and Thomas Jaki are organising a workshop on Adaptive Designs and Multiple Testing Procedures, happening today and tomorrow in Regensburg.

admtp.github.io/ADMTP2025/

BSU PhD students, Connor Fitchett and Weishi Chen, have presented today.

Photo of Connor Fitchett giving a presentation with projector screen of slide behind them.

Photo of Weishi Chen giving a presentation with projector screen of slide behind them.

2 2

Reposted by Thomas Jaki

domcouturier.bsky.social @domcouturier.bsky.social · Feb 17

The deadline to apply for a @mrc-bsu.bsky.social PhD studentship has been EXTENDED to March 27, 2025! 🗓️✨

Explore the exciting PhD projects available here: www.mrc-bsu.cam.ac.uk/phd-opportun... 🔍📚

🌟 Special shoutout to the project by @thomasjaki.bsky.social and myself 👼

PhD Opportunities | MRC Biostatistics Unit

shutterstock_337964138_students_small.jpg We actively support equality, diversity and inclusion and encourage applications from all sections of society. We are committed to widening participation in ...

www.mrc-bsu.cam.ac.uk

3 3

Reposted by Thomas Jaki

Charlotte Summers @charlottesummers.bsky.social · Feb 15

I suspect many of us need to hear this today. @charliemackesy1.bsky.social

3 8 58

Reposted by Thomas Jaki

Stormageddon, Dark Lord of All @stormageddon.bsky.social · Dec 2

Bioresonanz. Die Älteren von euch erinnern sich ja daran, dass ich diese Studie so mag.

link.springer.com/article/10.1...

Warum ist diese Studie so toll?

Weil keine andere Studie Bioresonanz an Menschen, Leberkäse(!), einem feuchten Tuch sowie einem Leichnam(!) ausprobiert hat.

Ein paar Zitate:

Einfache Testverfahren zur Überprüfung der Aussagekraft von Bioresonanz-basierten medizinischen Befunden — der Leberkäse-Test - Allergo Journal

Allergo Journal - Trotz aller Aufklärungsarbeit wird die Bioresonanz weiter benutzt. Seit einigen Jahren sind modifizierte Geräte auf dem Markt, die auch in Reformhäusern zum Einsatz...

link.springer.com

43 190 550

Reposted by Thomas Jaki

pmozgunov.bsky.social @pmozgunov.bsky.social · Nov 26

I am looking for a PhD student in Medical Statistics. This project aims to develop new methods for design of early phase trials starting from monotherapy and progressing into combinations. More details are in the link. Feel free to contact me if any questions. www.findaphd.com/phds/project...

Designs for sequences of early phase (modular) studies at University of Cambridge on FindAPhD.com

PhD Project - Designs for sequences of early phase (modular) studies at University of Cambridge, listed on FindAPhD.com

www.findaphd.com

6 6

Thomas Jaki @thomasjaki.bsky.social · Nov 25

Interested in learning about Bayesian Clinical Trials? We are running a 2-day short course (24th-25th February 2025) on the topic directly prior to the Adaptive Designs and Multiple Testing Procedures Workshop.

To register and more information visit admtp.github.io/ADMTP2025/co...

1 4

Reposted by Thomas Jaki

Jonathan Bartlett @jonathan-bartlett.bsky.social · Nov 21

Our 3 day short course @lshtm.bsky.social on multiple imputation for missing data using R is now open for registration. 17-19 June 2025. This year the course will be online only. More info here: www.lshtm.ac.uk/study/course...

Statistical Analysis with Missing Data Using Multiple Imputation | LSHTM

www.lshtm.ac.uk

6 7

Thomas Jaki @thomasjaki.bsky.social · Nov 19

Our design for the early phase platform AGILE for treatments for COVID-19 has just been published.

journals.sagepub.com/doi/10.1177/...

A seamless Phase I/II platform design with a time-to-event efficacy endpoint for potential COVID-19 therapies - Thomas Jaki, Helen Barnett, Andrew Titman, Pavel Mozgunov, 2024

In the search for effective treatments for COVID-19, the initial emphasis has been on re-purposed treatments. To maximize the chances of finding successful trea...

journals.sagepub.com

3

Reposted by Thomas Jaki

Munya Dimairo @mdimairo.bsky.social · Nov 14

Our part 2 series paper in peer review...

Confidence intervals for adaptive trial designs II: Case study and practical guidance

arxiv.org/abs/2411.08771

Confidence intervals for adaptive trial designs II: Case study and practical guidance

In adaptive clinical trials, the conventional confidence interval (CI) for a treatment effect is prone to undesirable properties such as undercoverage and potential inconsistency with the final hypoth...

arxiv.org

5 8

Reposted by Thomas Jaki

Munya Dimairo @mdimairo.bsky.social · Nov 14

Our part 1 series paper in peer review ...

Confidence intervals for adaptive trial designs I: A methodological review

arxiv.org/abs/2411.08495

Confidence intervals for adaptive trial designs I: A methodological review

Regulatory guidance notes the need for caution in the interpretation of confidence intervals (CIs) constructed during and after an adaptive clinical trial. Conventional CIs of the treatment effects ar...

arxiv.org

4 5

Thomas Jaki @thomasjaki.bsky.social · Oct 25

Registration is open for the next Adaptive Designs and Multiple Testing Procedures Workshop (taking place on 26th-27th February 2025 in Regensburg, Germany). For further details and to register, please see admtp.github.io/ADMTP2025/regi…

1 3