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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 4h

🧠 Today is #WorldMentalHealthDay - a reminder of how mental health connects to overall brain health.

At TIME-AD, we’re advancing research on how depression and its treatment shape brain health and risk of #dementia. Read about it here: www.time-ad.org/projects/oce...

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 2d

👁️ In recognition of #WorldSightDay tomorrow, we’re spotlighting our research on how sensory impairments influence dementia risk, and whether treatments like cataract surgery could help reduce that risk.

🔗 Learn more: www.time-ad.org/projects/sus...

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 4d

It’s Mental Illness Awareness Week 🧠

This year’s theme, Building Connection, highlights the power of meaningful connections for mental health. At TIME-AD, we study how depression, treatment, and social isolation shape dementia risk.

Read about it here: www.time-ad.org/projects

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 7d

📊 In TIME-AD’s latest publication, researchers combined test scores across two cohorts reflecting a range of backgrounds to understand drivers of differences in cognitive aging.

🧠 Read the article here: tinyurl.com/43ss93ry

#EpiSky #NeuroSky

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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 9d

Today, on #InternationalDayOfOlderPersons, we celebrate the important role that older adults play in our families, communities, and societies.

At TIME-AD, we’re striving for a dementia-free future by studying how to reduce risks and support healthy brain aging 🌍

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 11d

Did you know❓

There are estimated to be over 55 million people worldwide living with #dementia.

TIME-AD examines various interventions that could help reduce the risk of developing Alzheimer’s disease and related dementias.

Learn about our work: www.time-ad.org

@alzint.org

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 14d

🌟 Scientist Spotlight: Yulin Yang, Postdoctoral Researcher, UCSF

Yulin explores how social isolation can contribute to and result from pain and Alzheimer’s disease–related dementias (ADRDs).

🔗 Learn more: www.time-ad.org/yulin-yang

#ScientistSpotlight #TIME-AD

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 15d

🔁 ICYMI: In a recent #TIMEAD publication, we share methods to compare findings from dementia studies that use different cognitive tests. This helps researchers to better compare the impact of interventions.

📄 Read the full article: pubmed.ncbi.nlm.nih.gov/40000573/

#ADRD

Methods to crosswalk between cognitive test scores using data from the Alzheimer's Disease Neuroimaging Cohort - PubMed

Developed methods to crosswalk from one cognitive outcome to another in studies of dementia interventions. Methods illustrated using combinations of global cognitive tests: the CDR-SB, MoCA, and MMSE....

pubmed.ncbi.nlm.nih.gov

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 18d

Yesterday #WorldAlzheimersDay 🧠

57M people live with #ADRD worldwide. Research points to ways to prevent up to 45% of cases.

TIME-AD is advancing knowledge and bringing together data to reduce this burden.

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 21d

Social and clinical factors shape dementia and care experiences. Silvia Miramontes, TIME-AD investigator, studies patient data to spot and close gaps in care.

🔗 Learn more about her research and motivations: www.time-ad.org/silvia-miram...

#TIME-AD #ResearchReflections

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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 22d

September is #HealthyAgingMonth and #DeafAwarenessMonth 🩺

Read about what TIME-AD is doing to understand the link between hearing loss and dementia: www.time-ad.org/projects/sus...

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 25d

TIME-AD turns 1! 🎉

Over the past year, we’ve combined diverse data and innovative methods to explore ways to prevent dementia.

🌐 Learn more: www.time-ad.org

#TIMEAD #ADRD

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · 27d

🔎 Meta-analysis and triangulation depend on credible science.

📈 TIME-AD’s latest paper, led by Dr. Sarah Ackley, examines 20,000+ abstracts using an LLM to determine whether P value trends reflect changes in p-hacking, publication bias, or statistical power.

Read it: tinyurl.com/3f3nuxma

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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Sep 10

Social isolation is linked to poor mental health and higher risk of dementia in older adults. TIME-AD investigators like Mary are studying how to intervene with meaningful social connection.

🔗 Read more: www.time-ad.org/mary-thoma

#TIME-AD #ResearchReflections

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Sep 8

🔁 ICYMI: TIME-AD introduces the AI-Y Checklist, a framework for evaluating the development and deployment of AI tools in population health through an ethical lens.

🔗 Check it out: link.springer.com/article/10.1...

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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Sep 5

🚨 New from TIME-AD: Researchers developed measure to capture social isolation in the Health & Retirement Study. It works for all participants and will help show how isolation contributes to Alzheimer’s & dementia.

📖 Read it in JAGS: agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Sep 3

🔁 ICYMI: TIME-AD published an article in the American Journal of Epidemiology on “The Association of Alzheimer's Disease Genetic Risk with Social Connectedness in Middle- And Older-Ages”

Read it here: pubmed.ncbi.nlm.nih.gov/40512627/

The Association of Alzheimer's Disease Genetic Risk with Social Connectedness in Middle- And Older-Ages - PubMed

Observational evidence suggests that social connectedness protects against Alzheimer's Disease (AD), but reverse causality has not been ruled out. We evaluated the potential for a reverse path by esti...

pubmed.ncbi.nlm.nih.gov

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Sep 1

🌍 September is #WorldAlzheimersMonth

🧠 #TIME-AD is advancing research on modifiable risk factors that could inform interventions with the goal of healthy brain aging.

🔗 www.time-ad.org

#AskAboutDementia #AskAboutAlzheimers

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 29

🔁 ICYMI from TIME-AD!

How much time and follow-up is needed to study cognitive decline over time?

🔗 Our article in the American Journal of Epidemiology breaks it down: academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaf049/8071273

#TIME-AD #EpiSky #NeuroSky

Are we there yet? Estimating the waves of follow-up required for stable effect estimates in cognitive aging research

Mary C Thoma, Jingxuan Wang, Elizabeth Rose Mayeda, Charles E McCulloch, Eleanor Hayes-Larson, Jacqueline M Torres, M Maria Glymour; Are we there yet? Esti

academic.oup.com

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 27

⚙️Check out the software we developed to accompany TIME-AD’s recent publication on methods to crosswalk between cognitive test scores.

It is under development and feedback is welcome!

🔗 Download & instructions: jrgant.github.io/cogxwalkr/

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Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 25

📊 Differences in cognitive tests make it hard to compare results across studies.

This new #TIME-AD article offers methods to align effect estimates to increase comparability across studies and trials.

🔗 pubmed.ncbi.nlm.nih.gov/40000573/

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 22

🔁 ICYMI at #AAIC25:

TIME-AD presented new research on whether removing amyloid from the brain can accurately predict declines in cognition and functioning.

📖 Read the preprint to learn more: www.medrxiv.org/content/10.1...

#TIMEAD #EpiSky

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 20

🌟 Scientist Spotlight: Silvia Miramontes, PhD Candidate, UCSF

Silvia’s research explores how clinical and social factors shape the trajectory of dementia

Outside the lab, you might find Silvia on a scenic run, a long walk, or at a city viewpoint.

🔗 Learn more: www.silviamiramontes.com

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 18

💡New from TIME-AD!

In our latest journal article, we introduce and apply a checklist for making sure AI is used responsibly across global health and research settings.

📊Check it out in Current Epidemiology Reports: link.springer.com/article/10.1...

#TIME-AD #ResponsibleAI

Triangulation of Innovative Methods to End Alzheimer’s Disease @timead.bsky.social · Aug 15

#ΨMCA2025 has come to an end!

We’re heading home energized after a week full of discussion around cognitive aging research 💬

Thank you to the organizers and all who joined us!

#TIME-AD #DementiaResearch

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