Traffic
@traffic-journal.bsky.social
43 followers
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onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.
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Traffic
@traffic-journal.bsky.social
· Aug 26
FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway
FGF signaling regulates lysosomal homeostasis in RCS chondrocytes by inducing TFEB/TFE3 nuclear translocation and activation. This promotes the expression of lysosomal genes and mannose 6-phosphate r....
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Aug 26
CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL‐L1
In this study, we characterize tubular recycling endosomes and demonstrate that they are dynamic and undergo biogenesis upon CD98 internalization and fission over time. We identify CD2AP and CIN85 as...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Jul 30
Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases
The three longin domain-containing GAP complexes - CSW, folliculin, and GATOR1 - have a sporadic but pan-eukaryotic distribution and were likely already present in LECA in some form. Their catalytic ...
onlinelibrary.wiley.com
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Traffic
@traffic-journal.bsky.social
· Jun 6
Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo‐Lysosomal Trafficking in Host Cells
Salmonella Typhimurium hijacks the host Qa-SNARE syntaxin 7 (STX7) to manipulate endo-lysosomal trafficking and sustain intracellular survival. STX7 displays cell–type–specific expression and localis...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Jun 6
TENT5/FAM46: An Enigmatic Family of Secretory Tuners
TENT5s multifaceted roles in key biological processes and human diseases. TENT5 is a family of four proteins (TENT5A–D) with tissue-specific functions influencing tumor proliferation, fertility, bone....
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Jun 6
A Sensitive and Versatile Cell‐Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion
In this study, Denus et al. develop a powerful and highly customizable split luciferase-based assay allowing the analysis of multiple cargo proteins released by unconventional protein secretion. This...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Jun 6
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms
Kinesin-1 is auto-inhibited and binds microtubules weakly. Binding of kinesin-1 to the adaptor protein BicD enhances processive motion, while the microtubule-associated protein MAP7 recruits more kin....
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Jun 6
TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· May 2
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...
doi.org
Traffic
@traffic-journal.bsky.social
· May 2
Re‐Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation
The transport of transferrin is among the most extensively studied trafficking processes. In this commentary, we utilize a mathematical simulation of the endomembrane system to revisit transferrin tr...
doi.org
Traffic
@traffic-journal.bsky.social
· Mar 19
Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation
Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Mar 19
Computational Modeling Reveals a Catch‐and‐Guide Interaction Between Kinesin‐1 and Tubulin C‐Terminal Tails
Previous experiments show a decrease in kinesin-1's processivity and velocity when tubulin C-terminal tails (CTTs) are cleaved, but the mechanism of these effects remains unclear. We devise competing...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Mar 19
Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes
TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis.
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Mar 19
Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface
The ER–Golgi interface has garnered significant attention due to recent discoveries suggesting potential non-vesicular transport mechanisms and regulation through liquid-liquid phase separation. Nume...
onlinelibrary.wiley.com
Traffic
@traffic-journal.bsky.social
· Mar 4
PcloC‐Mediated Phase Separation in Short‐Distance Vesicle Transport
Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component ...
onlinelibrary.wiley.com