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Reposted by Jennifer Trowbridge

Peter van Galen @vangalenlab.bsky.social · Sep 6

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

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Reposted by Jennifer Trowbridge

FASEB @faseborg.bsky.social · May 15

Celebrate 30 years of #HEMSRC with FASEB! Your research could be presented at the same meeting as hematology experts like @trowbridgelab.bsky.social and @juliamaxson.bsky.social. Submit your abstract by June 1 and save your space: buff.ly/2W1wk85

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Reposted by Jennifer Trowbridge

FASEB @faseborg.bsky.social · Apr 23

For 30 years, #HEMSRC has brought together researchers to share their important research. Join organizers @juliamaxson.bsky.social
and Sergei Doulatov alongside keynotes @trowbridgelab.bsky.social and George Vassiliou to network, learn, and find new therapies. Save your space: buff.ly/2QuHlti

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Reposted by Jennifer Trowbridge

Elmira @drelmira.bsky.social · Apr 16

Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.

Bluesky

lab.bsky.social

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Grateful for funding support for this work from NIH, EvansMDS & @llsusa.bsky.social

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with @marcmansour.bsky.social, @challenlab.bsky.social, @ericpietras.bsky.social, Kelsey Fisher-Wellman, @keisukeito-lab.bsky.social & Steven Chan

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

To me, one of the coolest things about these papers is that three different labs in three different countries (US, Canada, UK) INDEPENDENTLY observed the same foundational phenotype of increased mitochondrial OXPHOS in Dnmt3a-mutant hematopoietic stem & progenitor cells 🇨🇦🇬🇧🇺🇸

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Together, we report that mitochondrial activity is a targetable mechanism by which clonal hematopoiesis-mutant HSCs gain a selective advantage over wild-type HSCs.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

We find that MitoQ also targets elevated mitochondrial respiration and the selective advantage of human DNMT3A-mutant HSCs, supporting species conservation.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Exploiting elevated mitochondrial membrane potential, we used long-chain alkyl-TPP molecules (ex. MitoQ) that selectively accumulate in the mitochondria. These caused reduced mitochondrial respiration, apoptosis, and ablated the competitive advantage of Dnmt3a-mutant HSCs.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Dnmt3a-mutant HSCs have DNA hypomethylation and increased expression of oxidative phosphorylation gene signatures, increased functional OXPHOS capacity, high
mitochondrial membrane potential & greater dependence on mitochondrial respiration versus wild-type HSCs.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Using a mouse model of Dnmt3a-mutant CH that our lab previously developed, we found that mutant HSCs sustain elevated mitochondrial respiration which is associated with their resistance to aging-induced changes in the bone marrow microenvironment.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

Drivers of clonal hematopoiesis include aging and inflammation. How hematopoietic stem cells (HSCs) with somatic mutations gain a selective advantage in these contexts is an unresolved question that we set out to tackle.

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16

New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...

Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.

www.nature.com

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Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 11

I am honored to have been selected by my colleagues to serve a 4-year term as vice president & president of the International Society of Experimental Hematology. Now, as ever, uniting, empowering and inspiring our collective scientific community to press on is essential.

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Apr 10

The results are in 🗳️ Congratulations to our incoming 2025-2026 Board of Directors who will start their terms at the conclusion of #ISEH2025🏯 in September! 👏

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Jennifer Trowbridge @trowbridgelab.bsky.social · Feb 18

It is an honor to be considered alongside the fantastic @kentlab.bsky.social for the role of Vice President of ISEH. To all @ISEHSociety members: please make an important contribution to the society by voting. It's easy! Good luck to all of the nominees; we are in great hands!!

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Feb 17

Vote for the 2025-2026 Board of Directors! The election closes 18 March. You must be an ISEH member to cast a vote ➡️ Learn more: www.iseh.org/2025Election

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 20

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 20

Happy holidays from the Trowbridge lab! The festive games got a wee bit competitive this year 😅 Thanks James for the inspiration!

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

I'm so glad you stayed until the very end @paralkarlab.bsky.social! It was my honor to present a curated subset of the top abstracts presented at #ASH24. For those that couldn't make it, it is available for viewing on the @ash-hematology.bsky.social meeting app & webcasts are available online.

Vikram Paralkar @paralkarlab.bsky.social · Dec 10

I always try to stay until the BEST OF ASH, which is the very final session on the final day of ASH. It's the best way of getting an overview of the top abstracts. Excellent work by Scientific Chairs Jen Trowbridge (@trowbridgelab.bsky.social) and Sant-Rayn Pasricha. #ASH24

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

Lastly, a shout out to my co-chair Sant-Rayn Pasricha (whom I will nudge onto Bluesky!) for a lot of laughs, for keeping an at-times challenging job light and fun, & for literally sharing the spotlight with me. Wouldn't have wanted to partner with anyone else. Hope to see everyone at #ASH25!

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

I have learned more about the breadth and depth of the #hematology field than I ever knew before. I also learned that it's near impossible to keep up with social media posts while also having the scientific program co-chair role (my bad!). 5/n

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

I leave #ASH24 tired (obv!) but inspired. Thank you to the basic scientists, the drug developers, the clinical trialists, the practicing physicians that bring their best science, successes & failures, & unique perspectives to this meeting. 4/n

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

Behind the scenes, @ash-hematology.bsky.social staff are the most professional, hard-working partners that not only care deeply about hematology but also essential topics of DEI & health advocacy. They make the magic happen. Shout out to Alice Kuaban, Kelly Rose & Patricia Frustace. 3/n

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

The annual @ash-hematology.bsky.social meeting is a result of dedicated work of many, many brilliant volunteers over 18+ months. Scientific Committees (shout out to the chairs!), abstract reviewers, Committee for Scientific Affairs, Program Committee, Executive Committee. It's amazing. 2/n

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Jennifer Trowbridge @trowbridgelab.bsky.social · Dec 11

That's a wrap #ASH24! Co-chairing the scientific program was an unforgettable experience. Congratulations to the poster presenters, the oral abstract presenters, the invited speakers, the plenary presenters, late-breaking abstracts & those considered for 'Best of ASH'! A thread:

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