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Vaclav Veverka

@vaclav-veverka.bsky.social

270 followers 190 following 4 posts

Senior group-leader at IOCB (Chromatin Structural Biology Lab)/Cell Biology, Charles University in Prague Transcription and epigenetics seen through networks of intrinsically disordered proteins

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Vaclav Veverka @vaclav-veverka.bsky.social · 21d

How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145

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Reposted by Vaclav Veverka

Harvard Med Cell Biology @harvardcellbio.bsky.social · 24d

New work from the Moazed lab reveals the requirements for establishment & epigenetic stability of mammalian heterochromatin! www.cell.com/molecular-ce...

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...

www.cell.com

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Reposted by Vaclav Veverka

Lucas Farnung @lucas.farnunglab.com · Aug 29

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

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Vaclav Veverka @vaclav-veverka.bsky.social · Jul 23

Chromatin remodelers engage with transcription factors through β-catenin. A new story from @hodgeshc.bsky.social and @cermakova.bsky.social in Mol Cell reveals a key role for intrinsically disordered regions. Congratulations! We're really happy to help out.

H. Courtney Hodges @hodgeshc.bsky.social · Jul 22

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...

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Vaclav Veverka @vaclav-veverka.bsky.social · Jun 10

#TCTeAC awesome crowd

Vaclav Veverka @vaclav-veverka.bsky.social · May 28

Exploring unsettled biomolecular interactions with an NMR twist. A joint effort with the Obsil lab. www.nature.com/articles/s41...

Structural plasticity of the FOXO-DBD:p53-TAD interaction - Nature Communications

Interactions between human transcription factors Forkhead box O4 (FOXO4) and p53 promote cellular senescence and activate p21 transcription. Here, the AUs use NMR to characterise the transient nature ...

www.nature.com

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