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Reposted by VU Chemical Biology

VU Chemical Biology @vanderbiltvicb.bsky.social · 10d

📢 VICB Seminar
🗓️ Oct 15 | 12:15 PM | 1220 MRB III
🎤 Yan Zhang (Zhejiang Univ.)

Talk: “GPCR Exoframe Modulators: From de novo design to applications”

Co-sponsored by Pharmacology.
medschool.vanderbilt.edu/vicb/seminar...

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VU Chemical Biology @vanderbiltvicb.bsky.social · 21h

VICB is pleased to announce a collaboration with the
Carl R. Woese Institute for Genomic Biology in introducing LassoESM, a new language model designed to predict properties of lasso peptides.

@vubasicsciences.bsky.social @vanderbilt.edu #research #biology #collaboration #university

ChBE Illinois @chbeillinois.bsky.social · 1d

Meet LassoESM, a lasso peptide-tailored protein language model developed by a team from the Carl R. Woese Institute for Genomic Biology. ChBE professor Diwakar Shukla, project co-leader, has provided valuable insights into machine learning knowledge.

chbe.illinois.edu/news/stories...

Learning the language of lasso peptides to improve peptide engineering

chbe.illinois.edu

Reposted by VU Chemical Biology

ChBE Illinois @chbeillinois.bsky.social · 1d

Meet LassoESM, a lasso peptide-tailored protein language model developed by a team from the Carl R. Woese Institute for Genomic Biology. ChBE professor Diwakar Shukla, project co-leader, has provided valuable insights into machine learning knowledge.

chbe.illinois.edu/news/stories...

Learning the language of lasso peptides to improve peptide engineering

chbe.illinois.edu

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VU Chemical Biology @vanderbiltvicb.bsky.social · 21h

Vanderbilt’s Neuert lab unveils TrueSpot, an algorithm to better automate microscopy image analysis.

Learn more ⏩https://medschool.vanderbilt.edu/basic-sciences/2025/10/06/new-algorithmic-tool-can-improve-microscopy-image-analysis-making-improvements-across-fields/

@vubasicsciences.bsky.social

Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 8d

🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic.

Learn more 👉 medschool.vanderbilt.edu/basic-scienc...

Vanderbilt research looks to smooth out bumps in medicinal chemistry processes

Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

medschool.vanderbilt.edu

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Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 6d

🎉 Jeff Spraggins has been awarded a $4 million NSF grant to develop a next-generation molecular imaging platform. This cutting-edge technology aims to visualize biomolecules in tissues with greater clarity, helping researchers decode disease pathways. medschool.vanderbilt.edu/basic-scienc...

Spraggins awarded $4M NSF grant to develop next-generation molecular imaging platform

In addition to fueling cutting-edge research, a new molecular imaging system will serve as a cornerstone resource at the Mass Spectrometry Research Center, which is recognized nationally as a hub f…

medschool.vanderbilt.edu

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Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 5d

🎉 Congratulations to Prashant Donthamsetti on receiving the prestigious NIH Director's Pioneer Award to push forward research into next-generation strategies for understanding and treating addiction.

Read more 👉 medschool.vanderbilt.edu/basic-scienc...

Prashant Donthamsetti wins prestigious NIH pioneer award to advance addiction research

Prashant Donthamsetti has received a prestigious NIH Director’s Pioneer Award from the National Institute on Drug Abuse. His project will use a new platform called Tag-Guided Drug to uncover how sp…

medschool.vanderbilt.edu

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Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 1d

🔬 Proteins morph and respond to their environment in ways we’re only beginning to understand. A new collaborative project called diffUSE will advance our understanding of protein motion, reshaping how we study disease, drug design, and protein function. medschool.vanderbilt.edu/basic-scienc...

Beyond the fold: From single snapshots to shapeshifting proteins

Started in June 2025, a new collaborative science project called diffUSE involving Vanderbilt University, Cornell University, and the University of California, San Francisco, could be the next wate…

medschool.vanderbilt.edu

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VU Chemical Biology @vanderbiltvicb.bsky.social · 3d

🧬New research from VICB members

- Metalloproteome remodeling in A. baumannii
- LassoESM for lasso peptides
- Abasic sites & replisome progression
- Off-target of CF corrector VX-445
- Amino acid shifts & Salmonella colonization

➡️ Read more: medschool.vanderbilt.edu/vicb/

Homepage

Core Facility Molecular Design and Synthesis Center Access small molecules with defined or to-be-designed structures as well as hit-to-lead medicinal chemistry support. Learn More Core Facility High T...

medschool.vanderbilt.edu

VU Chemical Biology @vanderbiltvicb.bsky.social · 8d

Welcome to our newest PhD students in Basic Sciences!
🎉 Their journey begins with orientation & the Simple Beginnings ceremony, we’re excited to see where they go next.

More details: medschool.vanderbilt.edu/basic-scienc...

Vanderbilt School of Medicine Basic Sciences welcomes the next generation of biomedical scientists

The Vanderbilt University School of Medicine Basic Sciences welcomed 42 new graduate students into its Interdisciplinary Graduate Program and Quantitative and Chemical Biology Program through orientat...

medschool.vanderbilt.edu

VU Chemical Biology @vanderbiltvicb.bsky.social · 8d

⏰ Deadline coming up!

Apply by Oct 15 for the VICB Ambassador Travel Award. A chance to represent Vanderbilt, share your research, and inspire future scientists.

📩 Send apps to [email protected]

VU Chemical Biology @vanderbiltvicb.bsky.social · 10d

📢 VICB Seminar
🗓️ Oct 15 | 12:15 PM | 1220 MRB III
🎤 Yan Zhang (Zhejiang Univ.)

Talk: “GPCR Exoframe Modulators: From de novo design to applications”

Co-sponsored by Pharmacology.
medschool.vanderbilt.edu/vicb/seminar...

1

VU Chemical Biology @vanderbiltvicb.bsky.social · 10d

New research from Vanderbilt scientists sheds light on ion channel biology with potential implications for future therapies.

Read the latest: medschool.vanderbilt.edu/vicb/publica...

VU Chemical Biology @vanderbiltvicb.bsky.social · 15d

🛑 TODAY @12:15PM in 1220 MRB III

VU Chemical Biology @vanderbiltvicb.bsky.social · 17d

Join us as the Vanderbilt Institute of Chemical Biology (VICB) Wednesday, September 24!

Dr. Tobin Sosnick from the University of Chicago will present at 12:15PM in 1220 MRB III, hosted by Dr. Hassane Mchaourab.

medschool.vanderbilt.edu/vicb/seminar...

VU Chemical Biology @vanderbiltvicb.bsky.social · 15d

🔬 Vanderbilt research is tackling bottlenecks in medicinal chemistry — aiming to make drug discovery more efficient and reliable.

Read more from @VUBasicSciences:
medschool.vanderbilt.edu/basic-scienc...

#Medicinal #Chemistry #Drug #Discovery #Vanderbilt #Research
@vubasicsciences.bsky.social

Vanderbilt research looks to smooth out bumps in medicinal chemistry processes

Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

medschool.vanderbilt.edu

VU Chemical Biology @vanderbiltvicb.bsky.social · 17d

Join us as the Vanderbilt Institute of Chemical Biology (VICB) Wednesday, September 24!

Dr. Tobin Sosnick from the University of Chicago will present at 12:15PM in 1220 MRB III, hosted by Dr. Hassane Mchaourab.

medschool.vanderbilt.edu/vicb/seminar...

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VU Chemical Biology @vanderbiltvicb.bsky.social · 17d

🚨 New VICB Publications 🚨
From antidepressant mechanisms to infection biology, diabetes risk, RNA structure & cancer biology—our members are pushing discovery forward.

Read the latest here: medschool.vanderbilt.edu/vicb/publica...

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Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 17d

🎉 Congratulations to William Tansey and Douglas Kojetin on their new leadership roles at Vanderbilt-Ingram Cancer Center!

These leaders are stepping up to drive innovation, enhance collaboration, and accelerate cancer research at Vanderbilt. 🧬✨

Learn more 👉 news.vumc.org/2025/09/10/v...

Vanderbilt-Ingram Cancer Center names associate directors and new program leaders

Four high-profile researchers at Vanderbilt-Ingram Cancer Center have assumed new and varied leadership roles.

news.vumc.org

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Reposted by VU Chemical Biology

Vanderbilt School of Medicine Basic Sciences @vubasicsciences.bsky.social · 22d

A colorectal #cancer research team led by Robert Coffey (CDB), Stephen Fesik (Biochemistry), Ken Lau (CDB), and Bill Tansey (Biochemistry) has received a $12.6M SPORE #grant renewal from the National Cancer Institute 🎉

Learn more 👉 news.vumc.org/2025/09/08/s...

SPORE grant funds $12 million for colorectal cancer research

Vanderbilt colorectal cancer research team receives a Specialized Programs of Research Excellence grant renewal totaling $12.6 million.

news.vumc.org

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VU Chemical Biology @vanderbiltvicb.bsky.social · 22d

Join us TODAY, as the VICB seminar series continues!

We are excited to welcome Dr. Mo Seyedsayamdost from Princeton University, who will present “Natural Product Antibiotics: Past, Present, Future.”

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VU Chemical Biology @vanderbiltvicb.bsky.social · 28d

👏 Congrats to Dr. Prashant Donthamsetti on new NIH funding for his project developing a Tag-Guided Drug platform to study brain signaling with precision!

🔗 reporter.nih.gov/project-deta...

@vubasicsciences.bsky.social #research #nih #funding #brain #congrats #neuroscience #new #drugdiscovery

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VU Chemical Biology @vanderbiltvicb.bsky.social · 28d

A new study from the Douglas Kojetin lab (Biochemistry), led by staff scientist Paola Munoz-Telloby and graduate student Christopher Williams, used NMR to study Pin1–PPARγ binding, advancing insight into Pin1 catalysis and PPARγ regulation. bit.ly/488vJsw

Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics

By Cameron I. Cohen Amino acid peptides can exist in cis and trans conformations, with most heavily favoring the latter. Proline, however, is unique among amino acids in that its peptide bonds can sta...

bit.ly

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VU Chemical Biology @vanderbiltvicb.bsky.social · 28d

🎉 Congrats to VICB member David Cortez on receiving the Chancellor’s Award for Research at Vanderbilt’s Fall Faculty Assembly!

His Science paper on RAD51 and DNA replication is reshaping our understanding of genome stability.

www.vanderbilt.edu/csb/2025/07/...

Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics

By Cameron I. Cohen Amino acid peptides can exist in cis and trans conformations, with most heavily favoring the latter. Proline, however, is unique among amino acids in that its peptide bonds can sta...

www.vanderbilt.edu

VU Chemical Biology @vanderbiltvicb.bsky.social · Sep 9

🚨 New VICB Publications

📖 Peptide C-termini modification (bioRxiv)
🧪 Potent Mcl-1 inhibitors (J. Med. Chem.)
📑 Tryptophan halogenation (Angew. Chem. Int. Ed.)
🔬 Pin1 isomerization mechanism (PNAS)
💊 3D collagen screen in colorectal cancer (Comm. Biol.)
📍 Imaging neutral lipids (JASMS)

VU Chemical Biology @vanderbiltvicb.bsky.social · Sep 5

Join us Sept 10 at 12:15 PM in 1220 MRB III for the VICB Seminar with Christian Melander (Notre Dame):

“Small Molecule Approaches to Disarming Antibiotic Resistance Mechanisms.”

@vubasicsciences.bsky.social #lecture #notredame

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