We show that ERH and its associated RNA processing factors prevent intron retention in AU-rich regions of JAK2 transcripts. Loss of this regulation blocks JAK2 protein production and disrupts IFNγ signaling.
🆕 publication! Cells don’t just fight infection - they fine-tune their immune response. A new study from the Versteeg lab in @narjournal.bsky.social led by Adrian Söderholm uncovers how RNA processing of JAK2 helps regulate immune signals ➡️ tinyurl.com/2py27c8u @univie.ac.at @meduniwien.ac.at
New paper out in @natcomms.nature.com! A surprising story of a "non-conserved" protein that's vital for human cell fitness! Fantastic work by Alexandra Shulkina in collaboration with the @lcochella.bsky.social & @clausenlab.bsky.social labs.
