Last day repping @smolka-lab.bsky.social with @wjcomstock.bsky.social at the 73nd(?) #ASMS2025! Had an awesome time—already excited for next year!

Big thanks to everyone in the @smolka-lab.bsky.social for their support on this project! 🙏

My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out:
doi.org/10.1016/j.jb...

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS.

ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.

We applied it to DDR kinases. Please share.

www.biorxiv.org/content/10.1...

In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q!

Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization.

A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.