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xiangyiding.bsky.social
Xiangyi Ding
@xiangyiding.bsky.social
5 followers 9 following 5 posts
PhD Candidate @ucdavis | Starr–Luxton Lab | Cell biology & biophysics
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xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · 29d
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
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xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · 16d
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
gwgl.bsky.social
GW Gant Luxton @gwgl.bsky.social · 16d
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...
www.biorxiv.org
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Reposted by Xiangyi Ding
gwgl.bsky.social
GW Gant Luxton @gwgl.bsky.social · 29d
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
2 3 11
xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · 29d
Grateful to my mentors @danstarrucdavis.bsky.social and @gwgl.bsky.social. Huge thanks to @HongyanHao and @DanielElnatan for their key contributions, and to our collaborator @liamholt.bsky.social. Thanks to @alleninstitute.org and NIGMS for the funding and support to our research.
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xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · 29d
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
www.science.org
1 1 4
Reposted by Xiangyi Ding
gwgl.bsky.social
GW Gant Luxton @gwgl.bsky.social · Sep 9
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration
Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kines…
www.sciencedirect.com
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Reposted by Xiangyi Ding
genetics-gsa.bsky.social
Genetics Society of America @genetics-gsa.bsky.social · Jun 25
Ellen Gregory, @gwgl.bsky.social‬, & @danstarrucdavis.bsky.social‬ show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX
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xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · Jun 30
It was great to gave a plenary talk to the worm community 🪱 Received great questions and comments. Thanks to both of my PIs @gwgl.bsky.social and @danstarrucdavis.bsky.social for the co-mentorship and thanks to the organizers @genetics-gsa for bringing us together.
microbeminded.bsky.social
Buck Samuel 🪱🦠🧬🔬 @microbeminded.bsky.social · Jun 29
Amazing talk (and videos) in plenary 2 from Xiangyi Ding ( @danstarrucdavis.bsky.social ) about biophys constraints in cytoplasm. #Celegans cytoplasm is more like jelly than honey (human cells), plus found gene that constrains this mess particle diffusion. #worm25

www.biorxiv.org/content/10.1...
Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo
Understanding how cells control their biophysical properties during development remains a fundamental challenge. While cytoplasmic macromolecular crowding affects multiple cellular processes in single...
www.biorxiv.org
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xiangyiding.bsky.social
Xiangyi Ding @xiangyiding.bsky.social · Jun 30
Thank you so much! I’m tagging the other PI of mine @gwgl.bsky.social and as this work is made possible with both of my PIs support.
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