Ren et al. demonstrate pseudo-synaptic connections between sensory neurons and pancreatic ductal adenocarcinoma (PDAC) cells. These pseudo-synapses exhibit enrichment of NMDA receptor subunit GRIN2D/GluN2D, enhancing PDAC responsiveness to neuron-derived glutamate and promoting tumor growth. Disrupting glutamate-GRIN2D signaling at pseudo-synapses improves survival in PDAC, highlighting the therapeutic potential of targeting cancer-neuron-pseudo-synapses.

Nature Communications - Adult zebrafish are capable of heart regeneration, but how the collagenous injury site is replaced remains unclear. Here they provide an in-depth analysis of cardiomyocyte...

Background Identifying neural markers of clinical symptom fluctuations is prerequisite to developing more precise brain-targeted treatments in psychiatry. We have recently shown that working memory (W...

Nature Reviews Rheumatology, Published online: 13 November 2025; doi:10.1038/s41584-025-01323-9The factors and mechanisms that regulate osteoclast-induced inflammatory bone loss are complex. The authors of this Review provide an overview of osteoclast regulation in the context of inflammatory bone loss and rheumatoid arthritis and provide insights into potential treatment strategies.

Via genetic ablation of neurons, Mazloumi Gavgani et al. show that the nervous system is essential for defining axial polarity during whole-body regeneration in the sea anemone Nematostella vectensis.

The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...

Immunosuppressive monocyte-derived macrophages are key targets in cancer therapy; however, the mechanisms of their replenishment and functional plasticity remain elusive. In a recent issue of Nature, Hedge et al. challenge the conventional view that immunosuppressive macrophages are acquired exclusively through tumor microenvironment reprogramming; instead, their study demonstrates that the developmental fate of these macrophages is predisposed in the bone marrow.

Our research has uncovered a muscle-bone communication mechanism primarily mediated by IL-33, linking muscle dysfunction to bone loss. This interaction could be a promising therapeutic target for musc...

Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the r...

Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.

A single letter in the DNA code could change the course of human development