Huge thanks to @iguaracy.bsky.social and @epetsalaki.bsky.social for being such great collaborators, and to @ebi.embl.org for the opportunity through the EMBL CPP fellowship to visit/work at EBI in 2024! And for the Network Biology @cshlmeetings.bsky.social for nurturing this collaboration.

“I met Yifei Cai during the opening keynote by Dana Pe’er; we happened to sit next to each other and immediately connected over how exciting the talk was”. And that’s how our beautiful (and wonderfully productive) collaboration got started!

Many thanks Jaime! ❤️

haha, thanks so much, Jaime! That’s such a high compliment, really appreciate it!

Thanks so much, Lindsay! I'm also really excited about the potential of this proximity labeling proteomics approach for other neuro-glial applications. I can’t wait to try it, and if anyone's interested, I’d be more than happy to help and collaborate!

Many thanks to the generous support of my mentors @jgrutzendler.bsky.social , Angus Nairn, and many amazing collaborators @iguaracy.bsky.social @mslob95 and funding from the NIH, @embl.org, @brightfocus.bsky.social, @alzassociation.bsky.social, Yale/NIDA Neuroproteomics Center, and Yale ADRC.

This study was made possible by the generous support of my mentors @jgrutzendler.bsky.social, Angus Nairn, and Kristen Brennand, as well as many amazing collaborators and funding from the NIH, @brightfocus.bsky.social , @alzassociation.bsky.social , Yale/NIDA Neuroproteomics Center, and Yale ADRC.

In our most recent paper, we uncover the myelin-axon interactome in human brains and reveal molecular perturbations and structural disruptions at the myelin-axon interface in Alzheimer’s disease @jgrutzendler.bsky.social @epetsalaki.bsky.social @reimand.bsky.social
www.nature.com/articles/s41...

Excited to share that two studies from my postdoc research were published back to back! In the first, we uncovered the molecular basis of axon spheroids—a key hallmark of Alzheimer's disease—and demonstrated their potential reversibility.
www.nature.com/articles/s43...

Thanks Junjie!

Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease.

🔗 Read here: www.nature.com/articles/s43...

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

Many thanks, Jüri! It’s our privilege to have such an exciting and productive collaboration with you and your team! I'm very excited to see how integrative pathway analysis can be applied to subcellular proteomics data, and I look forward to seeing it extended to new data (types) in the future!