Zampieri Lab
@zampierilab.bsky.social
160 followers
170 following
20 posts
Systems Pharmacology and Biology Lab at @DepBiomedicine, University of Basel, Switzerland.
We exploit metabolic weaknesses for therapeutic applications.
www.zampierilab.org
Posts
Media
Videos
Starter Packs
Zampieri Lab
@zampierilab.bsky.social
· Aug 21
DBM Research Prize Winner 2024 / 2025
Congratulations to this year’s DBM research prize winner! As we enjoy our annual summer symposium, we would like to recognize Dr. Laurentz Schuhknecht from Mattia Zampieri’s Systems Pharmacology and B...
biomedizin.unibas.ch
Zampieri Lab
@zampierilab.bsky.social
· Jul 21
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
www.nature.com
Zampieri Lab
@zampierilab.bsky.social
· Jul 1
In-cell NMR reveals metabolic adaptations in central carbon pathways driving antibiotic tolerance in Salmonella Typhimurium
Antibiotic tolerance presents a significant challenge in eradicating bacterial infections, as tolerant strains can survive antibiotic treatment, contributing to the recurrence of infections and the de...
pubs.rsc.org
Zampieri Lab
@zampierilab.bsky.social
· May 27
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
Zampieri Lab
@zampierilab.bsky.social
· May 13
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.
Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...
www.biorxiv.org
Zampieri Lab
@zampierilab.bsky.social
· Mar 3
A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators
Abstract. Transcription factors (TFs) are often classified as activators or repressors, yet these context-dependent labels are inadequate to predict quanti
doi.org
Zampieri Lab
@zampierilab.bsky.social
· Feb 3
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
Zampieri Lab
@zampierilab.bsky.social
· Nov 28
Gut microbiota regulates stress responsivity via the circadian system
Gut microbes are known to modulate stress responsivity and behavior. Tofani et al.
demonstrate that such modulations occur via the circadian system. The oscillations
in gut microbiota composition regu...
www.cell.com
Zampieri Lab
@zampierilab.bsky.social
· Nov 28