Zampieri Lab
@zampierilab.bsky.social
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Systems Pharmacology and Biology Lab at @DepBiomedicine, University of Basel, Switzerland. We exploit metabolic weaknesses for therapeutic applications. www.zampierilab.org
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zampierilab.bsky.social
In our recent journal club, we discussed an impressive paper published in Nature Microbiology titled “A shared alarmone–GTP switch controls persister formation in bacteria”. A comprehensive work on a (p)ppGpp–GTP antagonism pathway!

Check it out:
doi.org/10.1038/s415...
A shared alarmone–GTP switch controls persister formation in bacteria - Nature Microbiology
Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.
doi.org
zampierilab.bsky.social
We are happy to welcome Charleen Braun, doing her Master’s degree in Bioanalytics at Coburg University of Applied Sciences with a specialization in Human Biology.
zampierilab.bsky.social
At our annual Summer Symposium, Laurentz Schuhknecht from our Lab received this year’s DBM Research Prize, for his groundbreaking work in drug discovery and systems pharmacology, published in Nature Biotechnology (Nature Portfolio) earlier this year.
biomedizin.unibas.ch/en/communica...
DBM Research Prize Winner 2024 / 2025
Congratulations to this year’s DBM research prize winner! As we enjoy our annual summer symposium, we would like to recognize Dr. Laurentz Schuhknecht from Mattia Zampieri’s Systems Pharmacology and B...
biomedizin.unibas.ch
zampierilab.bsky.social
We are happy to welcome Sandra Pflästerer, doing her Master’s degree in Molecular and Cellular Biology at Ludwig-Maximilian University.
zampierilab.bsky.social
In our recent journal club, we discussed a nice publication from Nature: “Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses”. These exciting findings open the door to approaches that regulate immunometabolism during bacterial infections.

www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
zampierilab.bsky.social
We are looking for highly motivated Master and Bachelor Students to work on computational projects to better understand how bacteria and cancer cells metabolically adapt to chemical perturbations. Write us and find out how to conduct your semester or master project in our lab!

www.zampierilab.org
Home - Zampieri Lab
By studying fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations, our lab aims at finding new and unconventional therapeutic strategies, fr...
www.zampierilab.org
zampierilab.bsky.social
A warm welcome to Dana Reddmann, Biochemistry Master's student at Freie Universität Berlin, starting her Master Thesis in our lab!
zampierilab.bsky.social
We are happy to welcome Elena Pintea, MSc-Student in the Drug Sciences program at the University of Basel.
zampierilab.bsky.social
A warm welcome to Thomas Gosselin-Monplaisir, visiting PhD-Student from Toulouse Biotechnology Institute.
zampierilab.bsky.social
Today in our journal club: impressive work by the group of S.M. Fendt KU Leuven, published in Nature:

www.nature.com/articles/s41...

Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
zampierilab.bsky.social
We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!

Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...
A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology
Mapping the metabolic effects of drugs helps define their mode of action.
www.nature.com
zampierilab.bsky.social
This is our new lab profile on @bsky.app ! Stay tuned for regular news and updates from our lab!