#NatMetab
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natmetabolism.nature.com
✨New issue✨

Check out the latest in #Metabolism research from across all disciplines 🧪

Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics!

www.nature.com/natmetab/vol...
October 24, 2025 at 7:50 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪

www.nature.com/natmetab/vol...
September 24, 2025 at 8:58 PM
natmetabolism.nature.com
RESEARCH | Hägele, Bosy-Westphal et al.( @uni-kiel.de ):

Short-term consumption of protein-rich ultra-processed foods doesn't prevent overeating but favourably affects energy partitioning

https://bit.ly/4jcKEDK ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance - Nature Metabolism
This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning.
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May 21, 2025 at 7:02 PM
natmetabolism.nature.com
RESEARCH | S Devlin, ME Patti et al (‪ @harvardmed.bsky.social‬ )

FGF19 increase in post-bariatric hypoglycaemia is mediated by #bile acid dysregulation.

https://bit.ly/3SpfdeJ ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia - Nature Metabolism
FGF19 increase in post-bariatric hypoglycaemia is mediated by bile acid dysregulation, and can be countered by inhibiting bile acid transport.
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May 26, 2025 at 7:01 PM
natmetabolism.nature.com
PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)

An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism
Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
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August 27, 2025 at 4:42 PM
natmetabolism.nature.com
RESEARCH | Y Chen, JS Zheng, L Tao et al. (Westlake, Sun Yat-Sen U)

The microbial metabolite 4HPAA protects against #obesity by modulating mucosal immunity and intestinal lipid uptake.

https://bit.ly/4j4Tl34 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
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May 13, 2025 at 7:10 PM
natmetabolism.nature.com
RESEARCH |
@hanseulkim.bsky.social‬ @hutlab.bsky.social‬ ‪@longnguyen.bsky.social‬ - @hsph.harvard.edu‬

Multi-omic profiling indicates widespread transkingdom gut dysbiosis in MASLD
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https://bit.ly/3JbUkSS ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease - Nature Metabolism
High-resolution multi-omic profiling indicates widespread gut dysbiosis in individuals with MASLD, also affecting the virome, and reveals microbial signatures that can classify MASLD and its subtypes.
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August 12, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH |

@simonsterson.bsky.social‬ @katajistolab.bsky.social‬ et al.

Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪

https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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August 21, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH | L Tu, Y Xu et al. (Baylor College of Medicine):

Vestibular glutamatergic neurons mediate motion-induced hypothermia and can be targeted to prevent diet-induced obesity 🧠 ✨

https://bit.ly/4mxlhzI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Vestibular neurons link motion sickness, behavioural thermoregulation and metabolic balance in mice - Nature Metabolism
Glutamatergic neurons in the parvocellular part of the medial vestibular nucleus mediate motion-induced hypothermia and can be targeted to prevent diet-induced obesity.
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May 15, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | AH Lee, VD Dixit et al.

‪@yaleschoolofmed.bsky.social‬

Reduced dietary availability of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans
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https://bit.ly/4lX21ur ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
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July 3, 2025 at 7:00 PM
natmetabolism.nature.com
RESEARCH | M Kumar, TA Ryan et al 🧪
@weillcornell.bsky.social‬

Under glucose-depleted conditions, neurons can use fatty acids as alternative source of energy to support synaptic function

https://bit.ly/47hkX2X ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism
Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.
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August 15, 2025 at 4:31 PM
natmetabolism.nature.com
NEWS&VIEWS | LO Dragsted, @hroager.bsky.social , @catalinacuparencu.bsky.social (U Copenhagen):

A methodology for assessing dietary intake using stool metagenomes to detect food DNA🧬💩

https://bit.ly/4lfJ1aK ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Querying stool for dietary information - Nature Metabolism
Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic data to detect food DNA from a broad range of foods.
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April 9, 2025 at 6:23 PM
natmetabolism.nature.com
✨New issue! ✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Macrophages, #Tcells, #Circadian biology, the effects of #Diet on #Body and #Brain - and many more topics!

www.nature.com/natmetab/vol...
March 26, 2025 at 4:46 PM
natmetabolism.nature.com
✨New issue!✨

🧪

Check out the latest in #metabolism research from across all disciplines.

Read about #Triglycerides in the #Brain, #CagriSema, #Exercise, #LipidMetabolism, the #Microbiome - and many more topics!

www.nature.com/natmetab/vol...
July 24, 2025 at 2:41 PM
natmetabolism.nature.com
COMMENT | @clemmensenc.bsky.social‬, @keisakamoto.bsky.social‬ et al (U Copenhagen)

Recent breakthroughs, innovations and future needs of therapeutic interventions to counteract obesity

https://bit.ly/4lMkCbY ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.
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August 26, 2025 at 4:42 PM
natmetabolism.nature.com
RESEARCH | @cdiener.com @gibbological.bsky.social et al. ( @isbscience.org @medunigraz.at )

Estimation of dietary intake from human stool by detecting food DNA in faecal metagenomes💩🧬

https://bit.ly/3YphSbw ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
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April 8, 2025 at 6:21 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines 🧫🐭👥

Read about #Obesity, #Diabetes, #Epidemiology, #Myokines, #Cancer, #Aging - and many more topics!

www.nature.com/natmetab/vol...
January 29, 2025 at 1:57 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #TumourMetabolism, #Lactate signalling, #WeighLoss, #Thermogenesis, #DietaryInterventions and many more topics!

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www.nature.com/natmetab/vol...
August 22, 2025 at 3:17 PM
natmetabolism.nature.com
RESEARCH BRIEFING | ‪@dylanduerre.bsky.social‬ @andreagalmozzi.bsky.social‬ et al. - ‪@uwmadison.bsky.social‬

A BCAA–haem axis regulates brown fat function

www.nature.com/articles/s42... ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
A BCAA–haem axis regulates brown fat function - Nature Metabolism
Activated brown adipose tissue takes up large amounts of branched-chain amino acids (BCAAs), but their fate remains unclear. We provide evidence of a metabolic link between BCAA catabolism and haem bi...
www.nature.com
June 18, 2025 at 2:06 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #EVs, #Exercise, #GlucoseMonitoring, #LiverMetabolism , #Mechanosensation, #Neurometabolism - and many more topics!

www.nature.com/natmetab/vol...
February 26, 2025 at 2:53 PM
natmetabolism.nature.com
RESEARCH | Ahrentløv, Rewitz et al. (U Copenhagen)

The gut hormone tachykinin is regulated by protein intake in flies and mice. In flies, Tk impacts food choices, sleep and lifespan
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https://bit.ly/4nI9OO9 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan - Nature Metabolism
The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.
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July 14, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | ‪@mic-certo.bsky.social‬ C Mauro et al. (U Birmingham)

Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism
Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
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September 9, 2025 at 4:48 PM
realbiomassspec.bsky.social
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism #NatMetab #MassSpec www.nature.com/articles/s42...
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism - Nature Metabolism
By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular partitioning.
www.nature.com
September 10, 2025 at 6:29 PM
natmetabolism.nature.com
RESEARCH | MJ Tol, Y Shimanaka, P Tontonoz et al. (UCLA)

Dietary omega6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis. 🧪

https://bit.ly/4fFED2o ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling - Nature Metabolism
Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.
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August 19, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH | W Huang, YM Shah et al. ( ‪@umich.edu‬ )

ACSL4-driven changes in lipid metabolism modulate the sensitivity of intestinal cells to ferroptosis, thereby exacerbating IBD 🧪

https://bit.ly/3HBrmeH ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD - Nature Metabolism
Acyl-CoA synthetase long-chain family 4 (ACSL4)-driven changes in lipid metabolism are shown to modulate the sensitivity of intestinal epithelial cells to ferroptosis, thereby exacerbating inflammatory bowel disease.
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August 14, 2025 at 4:31 PM