#NatMetab
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natmetabolism.nature.com
✨New issue✨

Check out the latest in #Metabolism research from across all disciplines 🧪

Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics!

www.nature.com/natmetab/vol...
October 24, 2025 at 7:50 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪

www.nature.com/natmetab/vol...
September 24, 2025 at 8:58 PM
realbiomassspec.bsky.social
In vivo itaconate tracing reveals degradation pathway and turnover kinetics #NatMetab #MassSpec www.nature.com/articles/s42...
In vivo itaconate tracing reveals degradation pathway and turnover kinetics - Nature Metabolism
In this study, Willenbockel et al. trace circulating itaconate in vivo to gain insight into its fate and systemic metabolism.
www.nature.com
September 11, 2025 at 12:22 PM
realbiomassspec.bsky.social
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism #NatMetab #MassSpec www.nature.com/articles/s42...
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism - Nature Metabolism
By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular partitioning.
www.nature.com
September 10, 2025 at 6:29 PM
natmetabolism.nature.com
RESEARCH | ‪@mic-certo.bsky.social‬ C Mauro et al. (U Birmingham)

Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism
Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.
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September 9, 2025 at 4:48 PM
natmetabolism.nature.com
RESEARCH |
@lydialynch.bsky.social et al
@harvardmed.bsky.social‬ , Trinity College, Princeton

Animal-based fats accelerate tumour growth in obese mice, whereas plant-based fats do not

https://bit.ly/4lVM6Mf ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
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September 4, 2025 at 4:48 PM
natmetabolism.nature.com
RESEARCH | Chu, Chow et al (Chin U Hong Kong)

In this clinical trial, fermentable foods are shown to improve the efficacy of metformin, partially due to changes in the gut microbiota

https://bit.ly/4g4w6q3 ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes - Nature Metabolism
In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin due, at least in part, to changes in gut microbiota composition.
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August 30, 2025 at 4:45 PM
natmetabolism.nature.com
PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)

An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism
Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
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August 27, 2025 at 4:42 PM
natmetabolism.nature.com
COMMENT | @clemmensenc.bsky.social‬, @keisakamoto.bsky.social‬ et al (U Copenhagen)

Recent breakthroughs, innovations and future needs of therapeutic interventions to counteract obesity

https://bit.ly/4lMkCbY ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.
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August 26, 2025 at 4:42 PM
natmetabolism.nature.com
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #TumourMetabolism, #Lactate signalling, #WeighLoss, #Thermogenesis, #DietaryInterventions and many more topics!

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www.nature.com/natmetab/vol...
August 22, 2025 at 3:17 PM
natmetabolism.nature.com
RESEARCH |

@simonsterson.bsky.social‬ @katajistolab.bsky.social‬ et al.

Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪

https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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August 21, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH | JM Jacobsen, RE Kuhre et al. (Novo Nordisk, U Copenhagen)

CagriSema overcomes metabolic adaptation in response to weight loss in rats 🧪

https://bit.ly/4fMb9jA ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure - Nature Metabolism
This carefully designed study demonstrates that CagriSema overcomes metabolic adaptation in response to weight loss in rats.
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August 20, 2025 at 4:32 PM
natmetabolism.nature.com
RESEARCH | MJ Tol, Y Shimanaka, P Tontonoz et al. (UCLA)

Dietary omega6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis. 🧪

https://bit.ly/4fFED2o ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling - Nature Metabolism
Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.
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August 19, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH | M Kumar, TA Ryan et al 🧪
@weillcornell.bsky.social‬

Under glucose-depleted conditions, neurons can use fatty acids as alternative source of energy to support synaptic function

https://bit.ly/47hkX2X ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism
Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.
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August 15, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH | W Huang, YM Shah et al. ( ‪@umich.edu‬ )

ACSL4-driven changes in lipid metabolism modulate the sensitivity of intestinal cells to ferroptosis, thereby exacerbating IBD 🧪

https://bit.ly/3HBrmeH ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD - Nature Metabolism
Acyl-CoA synthetase long-chain family 4 (ACSL4)-driven changes in lipid metabolism are shown to modulate the sensitivity of intestinal epithelial cells to ferroptosis, thereby exacerbating inflammatory bowel disease.
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August 14, 2025 at 4:31 PM
natmetabolism.nature.com
RESEARCH |
@hanseulkim.bsky.social‬ @hutlab.bsky.social‬ ‪@longnguyen.bsky.social‬ - @hsph.harvard.edu‬

Multi-omic profiling indicates widespread transkingdom gut dysbiosis in MASLD
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https://bit.ly/3JbUkSS ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease - Nature Metabolism
High-resolution multi-omic profiling indicates widespread gut dysbiosis in individuals with MASLD, also affecting the virome, and reveals microbial signatures that can classify MASLD and its subtypes.
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August 12, 2025 at 4:31 PM
realbiomassspec.bsky.social
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke #NatMetab #MassSpec www.nature.com/articles/s42...
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke - Nature Metabolism
Wang et al. report a workflow to perform quantitative mass spectrometry imaging and provide insight into spatial metabolic remodelling undergone in the mouse brain upon ischaemia.
www.nature.com
August 6, 2025 at 6:52 AM
natmetabolism.nature.com
✨New issue!✨

🧪

Check out the latest in #metabolism research from across all disciplines.

Read about #Triglycerides in the #Brain, #CagriSema, #Exercise, #LipidMetabolism, the #Microbiome - and many more topics!

www.nature.com/natmetab/vol...
July 24, 2025 at 2:41 PM
natmetabolism.nature.com
RESEARCH | B Jackson, @lydiafinley.bsky.social‬
@mskcancercenter.bsky.social‬

Metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrients
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https://bit.ly/4nWqEsH ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Intracellular metabolic gradients dictate dependence on exogenous pyruvate - Nature Metabolism
Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.
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July 17, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | Ahrentløv, Rewitz et al. (U Copenhagen)

The gut hormone tachykinin is regulated by protein intake in flies and mice. In flies, Tk impacts food choices, sleep and lifespan
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https://bit.ly/4nI9OO9 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan - Nature Metabolism
The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.
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July 14, 2025 at 7:01 PM
natmetabolism.nature.com
NEWS&VIEWS | W Zhong, K Wang & A Zarrinpar
‪@ucsandiego.bsky.social‬

A study demonstrates that modulation of hypothalamic circuits can rapidly alter gut microbiota composition.
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https://bit.ly/40ONngn ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Mind over microbiota: neurons call the shots in the gut - Nature Metabolism
Although the gut microbiota can influence brain function, evidence for brain activity-driven changes in microbial communities is limited. Here, the authors provide direct support for bidirectional communication in the brain-to-gut axis by demonstrating that modulation of hypothalamic circuits can rapidly alter gut microbiota composition.
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July 10, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | Cani, Nogueiras, Claret et al. (UCLouvain, U S de Compostela, U Barcelona)

Hypothalamic hormones can drive remodelling of the gut microbiota within short periods of time
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https://bit.ly/3GEIRKx ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice - Nature Metabolism
Toledo et al. show that metabolic hormones acting in the hypothalamus, along with direct manipulation of hypothalamic neurons, can drive remodelling of microbial communities in the gut within short periods of time.
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July 9, 2025 at 7:01 PM
natmetabolism.nature.com
NEWS&VIEWS | T Ramalho & RT Gazzinelli
‪@umasschan.bsky.social‬

Itaconate inhibits the active site of a peroxiredoxin to amplify type I interferon response in macrophages
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https://bit.ly/4lGa2Dw ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Itaconate boosts type I IFN response by disrupting cytoprotection - Nature Metabolism
A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages.
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July 8, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | T Paulenda, MN Artyomov et al. (WUSTL)

Itaconate inhibits the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby enhancing type I interferon production.
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https://bit.ly/44Y13ar ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Itaconate modulates immune responses via inhibition of peroxiredoxin 5 - Nature Metabolism
Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon production.
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July 7, 2025 at 7:01 PM
natmetabolism.nature.com
RESEARCH | AH Lee, VD Dixit et al.

‪@yaleschoolofmed.bsky.social‬

Reduced dietary availability of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans
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https://bit.ly/4lX21ur ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
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July 3, 2025 at 7:00 PM