With 121 exons #OBSCN codes for large mRNAs, not easily detectable in their full lengths. We used IntEREst #Bioconductor package to measure PSI for inclusion levles of each exon in #RNA & run differential exon inclusion across the studied samples. (5/6)

OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development scientiasalut.gencat.cat/handle/11351... #ScientiaVH

An interactive PSI visualization for the exon inclusion of OBSCN in pre- and post-natal muscle is available here👇. (4/6)

New #SkeletalMuscle paper: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development. #Myoblue tinyurl.com/3w3e2sbt

#OBSCN a #gene associated with #muscle function, has 121 exons. It codes for large RNAs, not easily detectable in their full lengths. We used IntEREst #Bioconductor package to measure PSI for inclusion of each exon in #RNA & run differential exon inclusion across the samples.

OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development skeletalmusclejournal.biomedcentral.com/articles/10.... #hvhebron #neuroped #obstetriciahvh [Text complet]

Our results suggest that the exon inclusion/skipping events in #OBSCN may be regulated by the expression of the #BUB3 gene, throughout skeletal & cardiac muscle development. (6/6)

Highly expressed in skeletal & cardiac muscles, #OBSCN is essential to #muscle function. Several OBSCN mutations associate with hypertrophic #cardiomyopathy & neuromuscular disorder. (3/6)

Correction: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development scientiasalut.gencat.cat/handle/11351... #ScientiaVH

Our paper about the alternative splicing of #OBSCN during skeletal #muscle and #cardiac muscle development, was just published in BMC #SkeletalMuscle, doi.org/10.1186/s133...

An interactive PSI visualization (developed using #RShiny) for the exon inclusion of #OBSCN in our studied pre- and post-natal skeletal and cardiac muscle samples is available at psivis.it.helsinki.fi:3838/OBSCN_PSIVIS/ , #NMD #AlternativeSplicing #RNA #PSIVIS