Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, transcriptionally activates #SASP in senescent SMCs
SMC Jpx KO⏬🐭#Atherosclerosis +⏬lesional SMC senescence SASP
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, transcriptionally activates #SASP in senescent SMCs
SMC Jpx KO⏬🐭#Atherosclerosis +⏬lesional SMC senescence SASP
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
#microRNA #LongNoncodingRNA
#microRNA #LongNoncodingRNA
JPX, a chromosome-associated regulatory RNA, complexes with BRD4 & p65 (NFκB subunit) to mediates 3D chromatin remodeling &⏫transcriptional activation of senescence secretome in #SmoothMuscleCell
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
JPX, a chromosome-associated regulatory RNA, complexes with BRD4 & p65 (NFκB subunit) to mediates 3D chromatin remodeling &⏫transcriptional activation of senescence secretome in #SmoothMuscleCell
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
#microRNA #LongNoncodingRNA #evolution #PepperedMoth #MonkeyFlower
#microRNA #LongNoncodingRNA #evolution #PepperedMoth #MonkeyFlower
LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei
A similar pro-intimal role in #Atherosclerosis?
#NatureComms 2024
www.nature.com/articles/s41...
LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei
A similar pro-intimal role in #Atherosclerosis?
#NatureComms 2024
www.nature.com/articles/s41...
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis
Serum lipids also regulated by PSMB8-AS1
#CircRes 2023
www.ahajournals.org/doi/10.1161/...
PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis
Serum lipids also regulated by PSMB8-AS1
#CircRes 2023
www.ahajournals.org/doi/10.1161/...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
#microRNA #LongNoncodingRNA #PepperedMoth #MonkeyFlower
#microRNA #LongNoncodingRNA #PepperedMoth #MonkeyFlower
Iliac artery n=79
T2D->⏬ACTA2-AS1
#SmoothMuscleCell microdissected from FFPE section
T2D->⏫LINC00910/RUFY1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG
#SciReports 2024
www.nature.com/articles/s41...
Iliac artery n=79
T2D->⏬ACTA2-AS1
#SmoothMuscleCell microdissected from FFPE section
T2D->⏫LINC00910/RUFY1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG
#SciReports 2024
www.nature.com/articles/s41...