came here to say Elsbeth!! TGW and TGF were amazing too but tonally different (andf*ckJulianna)
October 30, 2025 at 5:26 AM
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Tissue localization of NK cells dictates surveillance of lung metastasis, with TGF-β-resistant CD27high NK cells infiltrating metastatic nodules with therapeutic promise @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 3:38 PM
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New research from Boston Children’s Hospital! Dual reporter mESC line created to study joint lineage cell differentiation & the roles of TGF-β, Wnt, & MAPK signaling pathways in joint lineage specification in vitro & ex vivo https://ow.ly/bo4j50XhLUS ISSCR
October 30, 2025 at 1:55 PM
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OT = oxytocin (hormone that declines with age, supports tissue repair & homeostasis)
ALK5 inhibitor (A5i) = blocks the TGF-β pathway, which rises with age and drives inflammation & fibrosis.
ALK5 inhibitor (A5i) = blocks the TGF-β pathway, which rises with age and drives inflammation & fibrosis.
October 26, 2025 at 5:27 PM
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#SmoothMuscleCell m6A Epitranscriptomics
METTL3 as a direct target gene of YY1
METTL3-IGF2BP1 stabilizes MYH11 MYLK2 TGFβ2 mRNAs
SMC Yy1 or Mettl3 KO🐭
⏬vasoconstriction
↔️vasorelaxation
AAV-SM22-METTL2 iv ⏫arterial contractility of SMC Yy1 KO🐭
#CardiovascRes 2025
academic.oup.com/cardiovascre...
METTL3 as a direct target gene of YY1
METTL3-IGF2BP1 stabilizes MYH11 MYLK2 TGFβ2 mRNAs
SMC Yy1 or Mettl3 KO🐭
⏬vasoconstriction
↔️vasorelaxation
AAV-SM22-METTL2 iv ⏫arterial contractility of SMC Yy1 KO🐭
#CardiovascRes 2025
academic.oup.com/cardiovascre...
October 24, 2025 at 6:55 PM
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I had a great discussion with Danone Canada president Frederic Guichard last week at the Toronto Global Forum. Thank you so much for all those who attended and thank you TGF for the invite!
October 22, 2025 at 12:39 PM
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Só pra facilitar, nós na TGF estamos trabalhando num jogo de cartas, estilo de arte lembra bastante hearthtstone, vc consegue ver um pouco aqui pra referencia:
www.kickstarter.com/projects/the...
www.thegambitfoundry.com/riftblade
No caso ele é um boardgame, mas precisamos do 3D pra versao mobile
www.kickstarter.com/projects/the...
www.thegambitfoundry.com/riftblade
No caso ele é um boardgame, mas precisamos do 3D pra versao mobile
Riftblade
Crush Rival Mages in the Ultimate Deckbuilding Battler
www.kickstarter.com
October 14, 2025 at 5:27 PM
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Hao's Preprint Reading List
October 11 2025
Endothelial TGFBR1/2 inhibits neuroinflammation
Endothelial ZBTB16 inhibits heart aging
Smooth muscle TGFβ2 inhibits thoracic aortic aneurysm
Treg inhibits abdominal aortic aneurysm
Spatially-resolved👤multi-organ aging
docs.google.com/document/d/e...
October 11 2025
Endothelial TGFBR1/2 inhibits neuroinflammation
Endothelial ZBTB16 inhibits heart aging
Smooth muscle TGFβ2 inhibits thoracic aortic aneurysm
Treg inhibits abdominal aortic aneurysm
Spatially-resolved👤multi-organ aging
docs.google.com/document/d/e...
October 11, 2025 at 12:38 PM
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And another LYVE1⁺ macrophages! Here at septa of white fat, which guide adipocyte stem cells toward "white" fate via TGFβ1. Depleting septal LYVE1⁺ macrophages boosts beiging and counteracts obesity.
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential
Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose ...
doi.org
October 8, 2025 at 11:40 AM
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Northwestern University studied 48 people with neurological Long COVID.
Three blood proteins, C5a, TGFβ1, and Gliomedin, identified brain fog with 94% sensitivity and 86% specificity.
This points to a potential diagnostic test.
www.sciencedirect.com/science/arti...
Three blood proteins, C5a, TGFβ1, and Gliomedin, identified brain fog with 94% sensitivity and 86% specificity.
This points to a potential diagnostic test.
www.sciencedirect.com/science/arti...
Blood Diagnostic Biomarkers for neurologic manifestations of Long COVID.
SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19…
www.sciencedirect.com
October 1, 2025 at 12:35 AM
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9 saves
locked tf in
September 23, 2025 at 8:02 PM
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1 quotes
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Now this is podracing.
Trying out a new Double Alpha Academy rig for competition, this should be fun!
Trying out a new Double Alpha Academy rig for competition, this should be fun!
September 23, 2025 at 9:54 PM
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A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy @fredhutch.org
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
September 24, 2025 at 2:36 AM
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Hibernating brown bear serum modulates the balance of TGF-β and BMP pathways in human muscle cells
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Hibernating brown bear serum modulates the balance of TGF-β and BMP pathways in human muscle cells
Muscle atrophy is observed in several pathophysiological situations, including physical inactivity, leading to negative health consequences, without a…
www.sciencedirect.com
September 22, 2025 at 5:40 PM
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Very interesting paper from the Frangogiannis’s lab — #Fibroblast -Specific Loss of #TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted #Heart (and cardiac rupture) www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @einsteinmededu.bsky.social
Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart | Circulation
BACKGROUND: In patients surviving myocardial infarction, adipose tissue infiltration within the
scar is a common pathological finding and has been suggested to contribute to dysfunction
and arrhythmog...
www.ahajournals.org
September 20, 2025 at 10:00 PM
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1) A new paper by the Scheibenbogen group reports that ME/CFS and Long Covid patients have more antibodies that target proteins with arginine-rich (poly-R) sequences.
Examples are:
- the neuronal antigen SRRM3
- the ion channel SLC24A3
- the TGF-b signalling regulator TSPLY2
Examples are:
- the neuronal antigen SRRM3
- the ion channel SLC24A3
- the TGF-b signalling regulator TSPLY2
September 19, 2025 at 1:22 PM
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I hope he tells them them TGF
themselves.
themselves.
September 18, 2025 at 11:32 PM
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'Here, we found that traumatic injury induced recruitment of myeloid progenitor cells to the sprouting axons of sensory nerves, where they gradually acquired a nerve-associated mac-like profile. This identity change was driven & maintained by the immediate microenvironment, particularly by TGFβ'
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular
mechanisms guiding their sustained functional adaptation remain unclear. Kolter and
Döring et al. show that local i...
www.cell.com
September 14, 2025 at 9:02 AM
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3 reposts
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COVID-19 triggers kidney injury via viral damage, inflammation, and microvascular thrombosis.
Failed tubular repair leads to fibrosis and CKD, driven by senescence, mitochondrial dysfunction, and pro-fibrotic signaling like TGF-β and Wnt/β-catenin.
gemini.google.com/share/fdaea3...
Failed tubular repair leads to fibrosis and CKD, driven by senescence, mitochondrial dysfunction, and pro-fibrotic signaling like TGF-β and Wnt/β-catenin.
gemini.google.com/share/fdaea3...
Gemini - What are the key cellular and molecular pathways that govern the transition from Acute Kidney Injury (AKI) to Chronic Kidney Disease (CKD) in post-COVID patients? Does incomplete or maladapt...
Created with Gemini
gemini.google.com
September 14, 2025 at 4:02 PM
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A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
September 7, 2025 at 7:12 PM
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Sensory neurons shape local macrophage identity via TGF-β signaling @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
September 6, 2025 at 2:34 AM
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#Medsky🧪 #IDSky #Virosky #immunosky #publichealth The RGD motif on the #SARSCoV2 Spike protein activates TGF-β signaling by binding to integrins, a family of cell surface receptors. This signaling pathway,
September 6, 2025 at 10:53 AM
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Can you use DNA traps to fight tumors?
This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬
Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr
This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬
Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr
DNA Trash Cans: Outsmarting Tumor Signals with Origami Tech!
DNA origami creates innovative "tumor traps" that capture cancer-signaling molecules, offering a groundbreaking approach to targeting and neutralizing uncontrolled cellular growth.
plentyofroom.beehiiv.com
September 4, 2025 at 4:33 PM
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