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arvoiovs.bsky.social @arvoiovs.bsky.social · 2d

New genetics report in the IMI Myopia issue bit.ly/42yoJla by Virginie Verhoeven et al. from Erasmus MC University Medical Center provides an updated overview of current findings on myopia genetics and identifies priorities for future research.
doi.org/10.1167/iovs.66.13.22

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arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Achim Fieß et al. from Johannes Gutenberg University investigated optic nerve head morphology in children born preterm with and without retinopathy of prematurity.
doi.org/10.1167/iovs.66.13.21

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Mohammad Shahidullah et al. from the University of Arizona study the hydrostatic pressure responses to Piezo1 and TRPV4 in the mouse lens.
doi.org/10.1167/iovs.66.13.20

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Songtao Yuan, Xiying Mao et al. from Nanjing Medical University map macrophage diversity in Coats’ disease.
doi.org/10.1167/iovs.66.13.19

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Alexandre Reynaud et al. from McGill University investigate integration of visual motion signals in reduced visual conditions.
doi.org/10.1167/iovs.66.13.18

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Sarah Coupland et al. from the University of Liverpool predict monosomy 3 (M3) in uveal melanoma with clinical and histopathological features, including nuclear BRCA1-associated protein 1 immunohistochemistry and evaluate its prognostication performance.
doi.org/10.1167/iovs.66.13.17

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Marie-Louise Munch Bøegh et al. from Zealand University Hospital investigate vagal nerve function and correlation to CD4+ T-cell population in patients with neovascular age-related macular degeneration (nvAMD) and healthy individuals.
doi.org/10.1167/iovs.66.13.16

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Marie-Louise Munch Bøegh et al. from Zealand University Hospital investigate vagal nerve function and correlation to CD4+ T-cell population in patients with neovascular age-related macular degeneration (nvAMD) and healthy individuals.
doi.org/10.1167/iovs.66.13.16

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Yusuke Murakami et al. from Kyushu University describe a preclinical evaluation of pitavastatin nanoparticles for preserving cone photoreceptors in mouse models of RP.
doi.org/10.1167/iovs.66.13.15

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Anna Franziska Köller, Frank Schmitz et al. from Saarland University investigate alterations of photoreceptor synaptic ribbons in the retina of a human patient with oculocutaneous albinism type 1 (OCA1).
doi.org/10.1167/iovs.66.13.14

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Pei-Lung Chen, Ta-Ching Chen et al. from National Taiwan University enhance the molecular diagnosis of inherited retinal degeneration (IRD) by systematically identifying pathogenic splicing variants and characterizing their transcript-level consequences.
doi.org/10.1167/iovs.66.13.12

arvoiovs.bsky.social @arvoiovs.bsky.social · 3d

Linxin Xie, et al. from Shandong First Medical University perform comparative transcriptomic profiling of corneal compartments using single-cell and single-nucleus sequencing.
doi.org/10.1167/iovs.66.13.11

arvoiovs.bsky.social @arvoiovs.bsky.social · 6d

ason Comander et al. from Massachusetts Eye & Ear describe higher throughput assays for understanding the pathogenicity of variants of unknown significance in the RPE65 gene.
doi.org/10.1167/iovs.66.13.10

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arvoiovs.bsky.social @arvoiovs.bsky.social · 6d

Chenglong Yu et al. from Monash University develop and validate polygenic scores for retinal vessel calibers.
doi.org/10.1167/iovs.66.13.9

arvoiovs.bsky.social @arvoiovs.bsky.social · 9d

Siqi Xiong, Xiaobo Xia et al. from Xiangya Hospital find that the Transcription Factor Islet-1 Regulates Diabetes-Induced Inner Blood-Retinal Barrier Disruption.
doi.org/10.1167/iovs.66.13.8

arvoiovs.bsky.social @arvoiovs.bsky.social · 9d

Brian P. Brooks et al. from the National Eye Institute find that transgene-induced chromosomal rearrangement with aberrant human vascular endothelial growth factor at the optic fissure leads to uveal coloboma in mice.
doi.org/10.1167/iovs.66.13.7

arvoiovs.bsky.social @arvoiovs.bsky.social · 9d

Jong-Su Park, Chuanyu Guo & Xiangyun Wei from the University of Pittsburgh investigate the role of Crumbs2b in cone coalescence via planar orientational cell adhesions in zebrafish.
doi.org/10.1167/iovs.66.13.6

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Noelia Ruzafa et al. from the University of the Basque Country characterize the most resistant and vulnerable retinal ganglion cell subtypes in a chronic model of glaucoma in rats.
doi.org/10.1167/iovs.66.13.5

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Aman George et al. from the National Eye Institute @NatEyeInstitute find that TYROSINASE-deficient human retinal pigment epithelium exhibits melanosome maturation defects.
doi.org/10.1167/iovs.66.13.4

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Danli Shi et al. from Hong Kong Polytechnic University develop a deep learning algorithm for extracting features of choroidal vasculature from angiography images via a human-in-the-loop strategy and explore their relationship with multiple diseases.
doi.org/10.1167/iovs.66.13.3

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arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Lisa Brennan, Joshua Disatham & Marc Kantorow from Florida Atlantic University find that hypoxia-driven histone modifications govern gene regulation for mature eye lens formation.
doi.org/10.1167/iovs.66.13.2

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Cintia S. de Paiva et al. from the Cullen Eye Institute show how aging affects lipid homeostasis in lacrimal glands by upregulating lipogenesis and changing its specificity.
doi.org/10.1167/iovs.66.13.1

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Pascal-Raphael Blersch from Universitätsklinikum Erlangen investigate the efficacy of combining hyperthermic treatments with chemotherapeutics, such as cisplatin, docetaxel, & mitoxantrone, to develop better therapies for specific melanoma subtypes.
doi.org/10.1167/iovs.66.12.71

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Masuko Ushio-Fukai, Tohru Fukai et al. from the Medical College of Georgia investigate the novel role of copper transporter CTR1 and therapeutic potential of copper chelators in retinal ischemia-reperfusion injury.
doi.org/10.1167/iovs.66.12.70

arvoiovs.bsky.social @arvoiovs.bsky.social · 11d

Qingjiong Zhang, Wenmin Sun et al. from Zhongshan Ophthalmic Center investigate the pigmentation pattern of iris and fundus in 75 Chinese families with GPR143-associated ocular albinism.
doi.org/10.1167/iovs.66.12.69