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JorgeBenitez @benitezja.bsky.social · 1d

That’s an option and everyone is trying to target Myc… an alternative option is to target the downstream pathways activated by Myc or the whole output…

JorgeBenitez @benitezja.bsky.social · 4d

A chemical epigenetic tool to probe site-specific DNA-binding protein complexes www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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JorgeBenitez @benitezja.bsky.social · 9d

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer www.science.org/doi/10.1126/...

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

Gene expression programs directed by MYC mediate oncogenic KRAS signaling in pancreatic cancer.

www.science.org

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JorgeBenitez @benitezja.bsky.social · 12d

First-line immunotherapy with or without chemotherapy versus BRAF plus MEK inhibitors in BRAFV600E-mutated metastatic non-small-cell lung cancer (FRONT-BRAF): a multicentre, retrospective cohort study www.thelancet.com/journals/lan...

First-line immunotherapy with or without chemotherapy versus BRAF plus MEK inhibitors in BRAFV600E-mutated metastatic non-small-cell lung cancer (FRONT-BRAF): a multicentre, retrospective cohort study

First-line ICIs with or without chemotherapy were associated with improved overall survival compared with BRAF and MEK inhibitors in participants with metastatic BRAFV600E-mutated NSCLC, particularly ...

www.thelancet.com

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Reposted by JorgeBenitez

AI x Bio Discovery @aixbiobot.bsky.social · 12d

De novo design of phospho-tyrosine peptide binders [new]
Designs binders for phosphorylated tyrosine sites on clinically relevant targets using a deep generative framework, enabling modulation of signaling pathways.

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Reposted by JorgeBenitez

The Economist @economist.com · 12d

The top-ranked country this year, as it was last year, is tiny Switzerland. Sweden comes second and America third econ.st/46EuZKN

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JorgeBenitez @benitezja.bsky.social · 14d

How Much Water and Energy do Data Centers Consume? A New Jersey Bill Demands Answers. insideclimatenews.org/news/2409202...

How Much Water and Energy do Data Centers Consume? A New Jersey Bill Demands Answers. - Inside Climate News

If signed, the bill would make data centers release quarterly reports on water and electricity use.

insideclimatenews.org

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JorgeBenitez @benitezja.bsky.social · 18d

Combinatorial prediction of therapeutic perturbations using causally inspired neural networks www.nature.com/articles/s41...

Combinatorial prediction of therapeutic perturbations using causally inspired neural networks - Nature Biomedical Engineering

PDGrapher uses large datasets of genetic and chemical interventions to find genetic targets that shift a gene expression phenotype from a diseased to a normal state.

www.nature.com

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JorgeBenitez @benitezja.bsky.social · 20d

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability jamanetwork.com/journals/jam...

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

jamanetwork.com

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JorgeBenitez @benitezja.bsky.social · 20d

The immune microenvironment of colorectal cancer www.nature.com/articles/s41...

The immune microenvironment of colorectal cancer - Nature Reviews Cancer

In this Review, Kennel and Greten highlight the role of immune cells in colorectal cancer (CRC) development, progression and metastasis as well as the impact of therapies on the immune microenvironmen...

www.nature.com

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JorgeBenitez @benitezja.bsky.social · 25d

Aspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with PIK3CA hotspot mutations www.nejm.org/doi/full/10....

Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer | NEJM

Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. Observational studies suggest that aspirin may also improve disease-free survival after diagnosis,...

www.nejm.org

JorgeBenitez @benitezja.bsky.social · Sep 3

Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer www.sciencedirect.com/science/arti...

Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer

The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsa…

www.sciencedirect.com

JorgeBenitez @benitezja.bsky.social · Aug 27

Load and lock: An emerging class of therapeutics that influence macromolecular dissociation www.science.org/doi/10.1126/...

Load and lock: An emerging class of therapeutics that influence macromolecular dissociation

Biology is governed by macromolecular interactions, perturbation of which often lies at the heart of disease. Most therapeutic drugs, whether they are small molecules or biologics, exert their effects...

www.science.org

JorgeBenitez @benitezja.bsky.social · Aug 26

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation www.sciencedirect.com/science/arti...

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Glutarimide analogs, such as thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce degradation of certain zinc finger (ZF) proteins. Althou…

www.sciencedirect.com

JorgeBenitez @benitezja.bsky.social · Aug 12

Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer #proteindegradation #protacs aacrjournals.org/clincancerre...

Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer

Abstract. Purpose: BMS-986365, a heterobifunctional AR LDD, was designed as a potent cereblon-dependent degrader and competitive antagonist of AR to overcome resistance to ARPIs in metastatic prostate...

aacrjournals.org

JorgeBenitez @benitezja.bsky.social · Aug 7

Arvinas rules out a solo vepdegestrant launch www.oncologypipeline.com/apexonco/arv...

Arvinas rules out a solo vepdegestrant launch

If Pfizer hands back the estrogen receptor degrader, Arvinas will seek a new partner.

www.oncologypipeline.com

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JorgeBenitez @benitezja.bsky.social · Aug 5

T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma
aacrjournals.org/cancerdiscov...

T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Broad-spectrum RAS inhibition acts in concert with the immune system to achieve deep antitumor responses.

aacrjournals.org

JorgeBenitez @benitezja.bsky.social · Aug 1

Why Your Name Matters www.newyorker.com/tech/annals-...

Why Your Name Matters

www.newyorker.com

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JorgeBenitez @benitezja.bsky.social · Jul 31

Brainshuttle platform from Roche. Looking forward to see clinical trials coming up with this platform in neuroscience and neuro-oncology www.roche.com/stories/clev...