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Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets

Cell Biology J-Club @cellclub.bsky.social · 15h

Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets www.biorxiv.org/content/10.1...

Spatiotemporal heterogeneities in intracellular LD polarity are central to cellular homeostasis but remain largely unexplored. Here, we introduce Excitation Spectral Phasor Microscopy (ExSPM), which i...

Cell Biology J-Club @cellclub.bsky.social · 1d

Membrane protein condensates polymerize actin and form filopodia

Neuronal morphogenesis is guided by filopodia, dynamically generated plasma membrane protrusions filled with parallel actin filaments. However, how filopodial actin filaments are locally produced, org...

Cell Biology J-Club @cellclub.bsky.social · 1d

Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale

Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...

Cell Biology J-Club @cellclub.bsky.social · 2d

CROP2, a Retriever-PROPPIN Complex Mediating Protein Export from Endosomes to the Plasma Membrane

Endosomes generate tubulo-vesicular carriers to redistribute proteins between plasma membrane, Golgi, and lysosomes. These transport routes employ distinct combinations of sorting nexins with complexe...

www.nature.com/articles/s41...

Cell Biology J-Club @cellclub.bsky.social · 2d

Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins - Nature Communications

ATG16L1 is a key autophagic protein. Here, the authors elucidate the molecular basis of ATG16L1 interactions with FIP200 and ATG8 family proteins, showing that the interaction of ATG16L1 with FIP200 is indispensable for the effective autophagic flux.

www.nature.com

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Cell Biology J-Club @cellclub.bsky.social · 3d

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

www.science.org

Cell Biology J-Club @cellclub.bsky.social · 3d

Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation

Integrin-adhesion complexes (IACs) form spontaneously in cells on extracellular matrix substrates, allowing them to sense matrix composition and transduce force. However, IACs often do not form unifor...

ASPL couples the assembly of stress granules with their VCP-mediated disassembly

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Cell Biology J-Club @cellclub.bsky.social · 3d

ASPL couples the assembly of stress granules with their VCP-mediated disassembly | Science Advances www.science.org/doi/10.1126/...

Disease relevant molecular interactions link RNP granule assembly with their active disassembly.

www.science.org

www.science.org/doi/10.1126/...

Cell Biology J-Club @cellclub.bsky.social · 3d

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

www.science.org

www.nature.com/articles/s41...

Cell Biology J-Club @cellclub.bsky.social · 3d

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation - Nature Communications

ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and partner enzyme activities; together, they integrate lipid saturation and cholesterol signals.

www.nature.com

Cell Biology J-Club @cellclub.bsky.social · 4d

The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion | PNAS www.pnas.org/doi/10.1073/...

The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion | PNAS

Autophagy is a crucial intracellular pathway for maintaining cellular homeostasis. It involves forming double-membrane vesicles called autophagosom...

www.pnas.org

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Cell Biology J-Club @cellclub.bsky.social · 4d

Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts | The EMBO Journal www.embopress.org/doi/full/10....

Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts | The EMBO Journal

imageimageCancer-associated fibroblasts play key roles in the pancreatic tumor microenvironment, but their targeting has yet been unsuccessful. This work investigates intracellular trafficking of memb...

www.embopress.org

Cell Biology J-Club @cellclub.bsky.social · 4d

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes url: rupress.org/jcb/article-...

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

This study defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at endosome

rupress.org

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub

Cell Biology J-Club @cellclub.bsky.social · 5d

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub www.biorxiv.org/content/10.1...

The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

Cell Biology J-Club @cellclub.bsky.social · 5d

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates www.biorxiv.org/content/10.1...

The endoplasmic reticulum (ER)'s continuous morphology is tightly controlled by ER-shaping proteins, whose genetic or expression defects drive a spectrum of neurodegenerative disorders from Hereditary...

MBOAT7 and CDS2 coordinate lipid droplet dynamics and cholesterol metabolism in liver

Cell Biology J-Club @cellclub.bsky.social · 6d

MBOAT7 and CDS2 coordinate lipid droplet dynamics and cholesterol metabolism in liver www.biorxiv.org/content/10.1...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent disorder worldwide characterized by the accumulation of hepatic lipid droplets (LDs). However, the mechanisms by ...

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal

Cell Biology J-Club @cellclub.bsky.social · 6d

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal www.embopress.org/doi/full/10....

imageimageIn synucleinopathies such as Parkinson’s disease, the intrinsically disordered protein α-synuclein aggregates into amyloid fibrils. This study explores the effect of structural polymorphism ...

www.embopress.org

www.nobelprize.org/prizes/medic...

Cell Biology J-Club @cellclub.bsky.social · 7d

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Cell Biology J-Club @cellclub.bsky.social · 7d

The Lysosome Surface is an Unappreciated Hub for Vasopressin V2 Receptor Signaling www.biorxiv.org/content/10.1...

The Lysosome Surface is an Unappreciated Hub for Vasopressin V2 Receptor Signaling

G protein-coupled receptors (GPCRs) have traditionally been understood to signal through heterotrimeric G proteins exclusively from the cell surface followed by β-arrestin (βarr)-mediated desensitizat...

Tubulin Acetylation Deficiency Promotes Axonemal Turnover and Increases Cytoplasmic Microtubules

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Cell Biology J-Club @cellclub.bsky.social · 8d

Tubulin Acetylation Deficiency Promotes Axonemal Turnover and Increases Cytoplasmic Microtubules www.biorxiv.org/content/10.1...

Tubulin post translational modifications regulate microtubule dynamics; among these, α tubulin acetylation has been linked to microtubule stability. We generated a Chlamydomonas mutant lacking the ace...

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

Cell Biology J-Club @cellclub.bsky.social · 9d

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane www.biorxiv.org/content/10.1...

Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids through the regulation of the activities of numerous lipid-metabolizing enzymes and lipid transfer ...