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Christoph Heuser-Loy @cheuserloy.bsky.social · 1d

Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x

Targeting organelle function in T cells for cancer immunotherapy

Nature Reviews Immunology - In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being...

rdcu.be

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Reposted by Christoph Heuser-Loy

Adrian Liston @labliston.bsky.social · 16d

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry

High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

currentprotocols.onlinelibrary.wiley.com

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Reposted by Christoph Heuser-Loy

Dimitrios L. Wagner @dlwagner.bsky.social · 22d

You like engineering T cells, but you are missing the right flavor?

Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1

We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪

Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases

Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...

www.biorxiv.org

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Reposted by Christoph Heuser-Loy

Adrian Liston @labliston.bsky.social · 22d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Christoph Heuser-Loy @cheuserloy.bsky.social · 22d

Applications for postdocs (MD/PhD) to the Mildred Scheel School of Oncology are open: msso-cologne-bonn.de/application
👩‍🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍

Application

msso-cologne-bonn.de

Reposted by Christoph Heuser-Loy

Cluster of Excellence ImmunoSensation @immunosens.bsky.social · 24d

🚨 Open #position! The group of Zeinab Abdullah is looking for two PhD students for

a) Characterisation of hepatic NK-like T cells

b) Dissecting the role of STING signalling in anti-viral T cell responses

Application deadline: October 30

More information: www.immunosensation.de/opportunitie...

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Reposted by Christoph Heuser-Loy

Adrian Liston @labliston.bsky.social · Sep 3

🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

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Reposted by Christoph Heuser-Loy

Miguel Reina-Campos @reinacampos.bsky.social · Aug 14

I could not get myself to watch it but hopefully this inspires others to pursue immunology! Follow your curiosity folks and don't let the current leadership discourage you, tides ebb and flow - we are ultimately on the right boat. cheers

La Jolla Institute for Immunology (LJI) @lji.org · Aug 14

LJI Assistant Professor Miguel Reina-Campos, Ph.D. (@reinacampos.bsky.social) leads fascinating #ImmuneCell research in his lab. Now he's being recognized by @aai.org on a national stage!

Congrats, Dr. Reina-Campos!
www.youtube.com/watch?v=ib7O...

#SanDiego #Science #STEM #health #medicine

Miguel Reina Campos, Ph.D., on receiving a 2025 ASPIRE Award

YouTube video by The American Association of Immunologists (AAI)

www.youtube.com

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Christoph Heuser-Loy @cheuserloy.bsky.social · Aug 4

Gradually for sure, kicking in (long) before reaching PI status if you ask me...

Nature @nature.com · Jul 30

Somewhere along the way, things shift in terms of how PIs are seen by their students

go.nature.com/4kZYQRx

From bench to big boss: mitigating the widening gap between PI and lab

Laboratory dynamics can change as the age and experience of the principal investigator increase. But there are ways to combat this.

go.nature.com

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Reposted by Christoph Heuser-Loy

BaumjohannLab @baumjohannlab.bsky.social · Jul 22

🚨 There is a new W2 Professorship for Tumor Immunology (permanent position) available in our department. 🎓 🧫 🧪 🔬

ℹ️ Check out the details here: www.uni-bonn.de/en/universit...

⏰ Apply now! Application deadline is August 26, 2025.

📢 Please share!

@unibonn.bsky.social @immunosens.bsky.social

W2 Professorship for Tumor Immunology

W2 Professorship

www.uni-bonn.de

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Reposted by Christoph Heuser-Loy

Superbugs 🦠🔬🏫🧒🏽 @superbugs.bsky.social · Jan 20

Naive T cell vs Killer T cell

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Christoph Heuser-Loy @cheuserloy.bsky.social · Jan 17

It was fitting more often than not last year, from my experience www.zeit.de/mobilitaet/2...

European Championship: How to Deutsche Bahn

Foreign football fans beware: riding the train in Germany is, uh, speziell. If you want to survive, here is what you need to know.

www.zeit.de

Reposted by Christoph Heuser-Loy

Adrian Liston @labliston.bsky.social · Jan 17

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

onlinelibrary.wiley.com

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Reposted by Christoph Heuser-Loy

Cluster of Excellence ImmunoSensation @immunosens.bsky.social · Jan 15

🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a

Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity

Application deadline is February 10!

Visit our website for more information.

#job #postdoc #science #immunology

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Reposted by Christoph Heuser-Loy

Prasad Jallepalli, MD, PhD @prasad.bsky.social · Dec 20

An excellent review on spike-in normalization in ChIP-seq. When done correctly, spike-in is a vast improvement in quantitation. However best practices are non-obvious. Suboptimal design & analysis are shown to lead to erroneous conclusions in the literature. www.nature.com/articles/s41...

The Wild West of spike-in normalization - Nature Biotechnology

The proper use of spike-in normalization in ChIP-seq improves sensitivity for detecting genome-wide changes between conditions, but improper use is common, calling some biological conclusions into que...

www.nature.com

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Reposted by Christoph Heuser-Loy

ImmunoSketch @immunosketch.bsky.social · Dec 31

Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines.

@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social

t.co/k5lwZHxzxi
#ImmunoSky 🧪

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Reposted by Christoph Heuser-Loy

Jon Lim, MRCP PhD @drjonlim.bsky.social · Dec 17

🔭 What’s in store next for cell therapy for solid tumours?

2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).

Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇

@natureportfolio.bsky.social

www.nature.com/articles/s43...

T cells lead the charge against solid tumors - Nature Cancer

In 2024, two groundbreaking approvals from the US Food and Drug Administration for T cell-based therapies that target solid tumors were achieved. Lifileucel, a polyclonal tumor-infiltrating lymphocyte...

www.nature.com

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Reposted by Christoph Heuser-Loy

Fabian Theis @fabiantheis.bsky.social · Dec 12

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1

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Reposted by Christoph Heuser-Loy

Josh Leonard @josh-leonard.bsky.social · Nov 27

VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
www.nature.com/articles/s41...

Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery ...

Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting d...

www.nature.com

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Reposted by Christoph Heuser-Loy

WirtschaftsWoche @wirtschaftswoche.bsky.social · Dec 8

Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.

Tauchsieder: Die Bonner Bubble-Republik

Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.

www.wiwo.de

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Christoph Heuser-Loy @cheuserloy.bsky.social · Dec 2

Great meeting, great science! Thank you for bringing everyone together @kischober.bsky.social

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Christoph Heuser-Loy @cheuserloy.bsky.social · Dec 2

Would be great if you could add me, too 😃

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Reposted by Christoph Heuser-Loy

Andrea Schmidts @schmidts.bsky.social · Nov 26

Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)

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Christoph Heuser-Loy @cheuserloy.bsky.social · Nov 19

Looking forward to expanding the network here. Let's paint the #immunosky with more stars!

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Christoph Heuser-Loy @cheuserloy.bsky.social · Nov 19

Earlier this year, it was my great pleasure commenting on the findings from the Tang lab at EPFL (www.epfl.ch/labs/tang-lab/) in Nature Biotech re/ IL-10/STAT3 & mitochondrial fitness in CAR T cells.

Article: doi.org/10.1038/s415...
Commentary: doi.org/10.1002/cac2...

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases - Nature Biotechnology

CAR T cells engineered to express IL-10 eradicate solid tumors and metastases.

doi.org

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