Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

What do GWAS and rare variant burden tests discover, and why?

Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?

Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)

www.biorxiv.org/content/10.1...

...........

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

we are very interested using our recently developed combinatorial Cas12a CRISPRi platform. happy to chat!

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

#FragileNucleosome seminar happening tomorrow!

Looking forward to sharing our work in the #FragileNucleosome series!

We're still recruiting!

We've successfully recruited one postdoc. We are still looking to recruit one more postdoc especially candidates with wet/dry lab hybrid background in genome regulation and/or interests in functional genomics approaches in novel human tissue biology models.

Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: are generally rare (2.3%)

www.biorxiv.org/content/10.1...

Happy new year! Our lab (hsiunglab.org) at UCSF is moving forward to next stages in our search for postdoc candidates. The positions are still open -- if interested please apply soon!

A little fun with numbers on this Sunday, showing just how successful DNA really is. First, here's what DNA looks like. I'll draw your attention to the "rise" in DNA, that is, the distance between two basepairs, which is 3.4 Angstroms, also known as 3.4x10^-10 meters...

Honored to be endorsed in your first post here!!

Where appropriate there would be exceptional opportunities to work collaboratively with the help of junior specialists in the lab, as well as with other UCSF labs with complementary expertise.

We esp. welcome individuals who add to our capabilities and perspectives in computation or specific biological domains in tissue biology.

My lab at UCSF (hsiunglab.org) is looking to recruit multiple postdocs across the spectrum of wet/dry lab interests to contribute to our research in synthetic gene regulation, combinatorial genetics, and tissue biology (including liver biology and immuno-oncology).