Anders Sejr Hansen
@andersshansen.bsky.social
Associate Professor at MIT BE : http://ashansenlab.com
Interested in understanding the relationship between 3D genome structure and function
Interested in understanding the relationship between 3D genome structure and function
Reposted by Anders Sejr Hansen
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
January 1, 2026 at 7:03 PM
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Reposted by Anders Sejr Hansen
We co-submitted this article with the work of @andersshansen.bsky.social , @irate-physicist.bsky.social , and authors, who characterize similar cre microcompartments : rdcu.be/eWK1u
Dynamics of microcompartment formation at the mitosis-to-G1 transition
Nature Structural & Molecular Biology - Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and...
rdcu.be
December 29, 2025 at 1:05 PM
We co-submitted this article with the work of @andersshansen.bsky.social , @irate-physicist.bsky.social , and authors, who characterize similar cre microcompartments : rdcu.be/eWK1u
Reposted by Anders Sejr Hansen
Happy to share that my postdoc work with @jobdekker.bsky.social is out!
rdcu.be/eWHD2
We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.
rdcu.be/eWHD2
We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm
Nature Cell Biology - Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through...
rdcu.be
December 29, 2025 at 12:39 PM
Happy to share that my postdoc work with @jobdekker.bsky.social is out!
rdcu.be/eWHD2
We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.
rdcu.be/eWHD2
We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.
Reposted by Anders Sejr Hansen
Happy #FluorescenceFriday! Meet our CCCTC-binding factor cell line and plasmid. It illuminates a binding site involved in transcription and is available for just the cost of shipping!
📦 @coriellinstitute.bsky.social and @addgene.bsky.social
📦 @coriellinstitute.bsky.social and @addgene.bsky.social
December 26, 2025 at 9:12 PM
Happy #FluorescenceFriday! Meet our CCCTC-binding factor cell line and plasmid. It illuminates a binding site involved in transcription and is available for just the cost of shipping!
📦 @coriellinstitute.bsky.social and @addgene.bsky.social
📦 @coriellinstitute.bsky.social and @addgene.bsky.social
Reposted by Anders Sejr Hansen
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
December 23, 2025 at 2:51 AM
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
Excited to share a News & Views highlighting a new, excellent paper from @jobdekker.bsky.social and @allanaschooley.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inheriting chromosome conformation - Nature Cell Biology
Chromosomes unfold and refold each time cells divide. A study by Schooley et al. demonstrates that chromosome-intrinsic and cytoplasmic factors uniquely contribute to interphase chromosome structure, with new possibilities for how gene expression programs are passed from mother cells to daughter cells.
www.nature.com
December 23, 2025 at 2:51 AM
Excited to share a News & Views highlighting a new, excellent paper from @jobdekker.bsky.social and @allanaschooley.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
December 22, 2025 at 11:45 AM
See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
www.nature.com
December 22, 2025 at 6:56 PM
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
Reposted by Anders Sejr Hansen
Excellent @activemotifusa.bsky.social epigenetics podcast w @andersshansen.bsky.social
It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?)
Lots of ideas!
open.spotify.com/episode/19Nd...
It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?)
Lots of ideas!
open.spotify.com/episode/19Nd...
Region Capture Micro-C and 3D Genome Structure (Anders Sejr Hansen)
open.spotify.com
December 21, 2025 at 10:36 AM
Excellent @activemotifusa.bsky.social epigenetics podcast w @andersshansen.bsky.social
It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?)
Lots of ideas!
open.spotify.com/episode/19Nd...
It’s interesting, while going through specific projects and lines of questioning, the conversation acts as a nice reflection of the state of our field (fields?)
Lots of ideas!
open.spotify.com/episode/19Nd...
Reposted by Anders Sejr Hansen
An MIT lab director was killed in a shooting at his home in Brookline, Massachusetts Monday night, the school confirmed.
No one is in custody, Brookline police deputy superintendent said.
No one is in custody, Brookline police deputy superintendent said.
MIT professor Nuno Loureiro killed in shooting at his Brookline, Massachusetts home
MIT professor Nuno F.G. Loureiro was killed in a shooting at his home in Brookline, Massachusetts.
cbsn.ws
December 16, 2025 at 6:30 PM
An MIT lab director was killed in a shooting at his home in Brookline, Massachusetts Monday night, the school confirmed.
No one is in custody, Brookline police deputy superintendent said.
No one is in custody, Brookline police deputy superintendent said.
Reposted by Anders Sejr Hansen
Our (Viraat Goel, @andersshansen.bsky.social et al) paper Dynamics of microcompartment formation during the M-to-G1 transition is in this month's @natsmb.nature.com -- thanks to NSMB editors and staff for the cover space and art! www.nature.com/nsmb/volumes...
See quoted posts for quick summary
See quoted posts for quick summary
December 15, 2025 at 3:02 PM
Our (Viraat Goel, @andersshansen.bsky.social et al) paper Dynamics of microcompartment formation during the M-to-G1 transition is in this month's @natsmb.nature.com -- thanks to NSMB editors and staff for the cover space and art! www.nature.com/nsmb/volumes...
See quoted posts for quick summary
See quoted posts for quick summary
Reposted by Anders Sejr Hansen
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Anders Sejr Hansen
Absolutely fantastic Epigenetics and Genomics session on the latest frontiers of enhancer biology by @andersshansen.bsky.social, Martin Rivas and Mira Kassouf at the @ash.hematology.org annual meeting. Chaired by Megan McNerney.
December 6, 2025 at 3:44 PM
Absolutely fantastic Epigenetics and Genomics session on the latest frontiers of enhancer biology by @andersshansen.bsky.social, Martin Rivas and Mira Kassouf at the @ash.hematology.org annual meeting. Chaired by Megan McNerney.
Reposted by Anders Sejr Hansen
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 15, 2025 at 5:24 PM
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
November 14, 2025 at 8:01 AM
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
Reposted by Anders Sejr Hansen
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by Anders Sejr Hansen
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:51 PM
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...
October 20, 2025 at 7:05 PM
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...
Nice, they have such an elegant system to study chromosome conformation without nuclear import in their preprint www.biorxiv.org/content/10.1... and it was really nice to see we both came to similar findings and to be able to coordinate.
Interphase chromosome conformation is specified by distinct folding programs inherited via mitotic chromosomes or through the cytoplasm
Identity-specific interphase chromosome conformation must be re-established each time a cell divides. To understand how interphase folding is inherited, we developed an experimental approach that phys...
www.biorxiv.org
October 20, 2025 at 7:03 PM
Nice, they have such an elegant system to study chromosome conformation without nuclear import in their preprint www.biorxiv.org/content/10.1... and it was really nice to see we both came to similar findings and to be able to coordinate.
(8/8) Finally our preprint www.biorxiv.org/content/10.1... was co-submitted with the amazing work of @allanaschooley.bsky.social @jobdekker.bsky.social www.biorxiv.org/content/10.1... whose preprint should also be online soon and finds similar concepts in a different system. Thanks for coordinating!
Dynamics of microcompartment formation at the mitosis-to-G1 transition
As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D genome features including A/B-c...
www.biorxiv.org
October 20, 2025 at 7:00 PM
(8/8) Finally our preprint www.biorxiv.org/content/10.1... was co-submitted with the amazing work of @allanaschooley.bsky.social @jobdekker.bsky.social www.biorxiv.org/content/10.1... whose preprint should also be online soon and finds similar concepts in a different system. Thanks for coordinating!
(7/n) This was a wonderful team effort led by Viraat Goel, @irate-physicist.bsky.social @nicholas-aboreden.bsky.social James Jusuf in collab with Leonid Mirny and Gerd Blobel.
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
October 20, 2025 at 6:57 PM
(7/n) This was a wonderful team effort led by Viraat Goel, @irate-physicist.bsky.social @nicholas-aboreden.bsky.social James Jusuf in collab with Leonid Mirny and Gerd Blobel.
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
(6/n) Any cell change that changes chromosome compaction (e.g. mitosis, differentiation, mechanical, osmotic) would be expected to result in stronger A/B/micro-compartments without strongly affecting loop extrusion.
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
October 20, 2025 at 6:55 PM
(6/n) Any cell change that changes chromosome compaction (e.g. mitosis, differentiation, mechanical, osmotic) would be expected to result in stronger A/B/micro-compartments without strongly affecting loop extrusion.
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
(5/n) We think mitotic microcompartments are largely driven by entropy
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
October 20, 2025 at 6:52 PM
(5/n) We think mitotic microcompartments are largely driven by entropy
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction