Anders Sejr Hansen
@andersshansen.bsky.social
Associate Professor at MIT BE : http://ashansenlab.com
Interested in understanding the relationship between 3D genome structure and function
Interested in understanding the relationship between 3D genome structure and function
Reposted by Anders Sejr Hansen
We co-submitted this article with the work of @andersshansen.bsky.social , @irate-physicist.bsky.social , and authors, who characterize similar cre microcompartments : rdcu.be/eWK1u
Dynamics of microcompartment formation at the mitosis-to-G1 transition
Nature Structural & Molecular Biology - Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and...
rdcu.be
December 29, 2025 at 1:05 PM
We co-submitted this article with the work of @andersshansen.bsky.social , @irate-physicist.bsky.social , and authors, who characterize similar cre microcompartments : rdcu.be/eWK1u
Reposted by Anders Sejr Hansen
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
December 23, 2025 at 2:51 AM
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
December 22, 2025 at 11:45 AM
See this recent paper by @andersshansen.bsky.social that discovers similar microcompartmentalization during mitotic exit:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
Nice, they have such an elegant system to study chromosome conformation without nuclear import in their preprint www.biorxiv.org/content/10.1... and it was really nice to see we both came to similar findings and to be able to coordinate.
Interphase chromosome conformation is specified by distinct folding programs inherited via mitotic chromosomes or through the cytoplasm
Identity-specific interphase chromosome conformation must be re-established each time a cell divides. To understand how interphase folding is inherited, we developed an experimental approach that phys...
www.biorxiv.org
October 20, 2025 at 7:03 PM
Nice, they have such an elegant system to study chromosome conformation without nuclear import in their preprint www.biorxiv.org/content/10.1... and it was really nice to see we both came to similar findings and to be able to coordinate.
(8/8) Finally our preprint www.biorxiv.org/content/10.1... was co-submitted with the amazing work of @allanaschooley.bsky.social @jobdekker.bsky.social www.biorxiv.org/content/10.1... whose preprint should also be online soon and finds similar concepts in a different system. Thanks for coordinating!
Dynamics of microcompartment formation at the mitosis-to-G1 transition
As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D genome features including A/B-c...
www.biorxiv.org
October 20, 2025 at 7:00 PM
(8/8) Finally our preprint www.biorxiv.org/content/10.1... was co-submitted with the amazing work of @allanaschooley.bsky.social @jobdekker.bsky.social www.biorxiv.org/content/10.1... whose preprint should also be online soon and finds similar concepts in a different system. Thanks for coordinating!
(7/n) This was a wonderful team effort led by Viraat Goel, @irate-physicist.bsky.social @nicholas-aboreden.bsky.social James Jusuf in collab with Leonid Mirny and Gerd Blobel.
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
October 20, 2025 at 6:57 PM
(7/n) This was a wonderful team effort led by Viraat Goel, @irate-physicist.bsky.social @nicholas-aboreden.bsky.social James Jusuf in collab with Leonid Mirny and Gerd Blobel.
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
Thanks also to @dimitristypas.bsky.social @natsmb.nature.com and the reviewers for steering and improving the paper
(6/n) Any cell change that changes chromosome compaction (e.g. mitosis, differentiation, mechanical, osmotic) would be expected to result in stronger A/B/micro-compartments without strongly affecting loop extrusion.
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
October 20, 2025 at 6:55 PM
(6/n) Any cell change that changes chromosome compaction (e.g. mitosis, differentiation, mechanical, osmotic) would be expected to result in stronger A/B/micro-compartments without strongly affecting loop extrusion.
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
E.g. 2-fold compaction --> 6-fold MC dot change
www.nature.com/articles/s41...
(5/n) We think mitotic microcompartments are largely driven by entropy
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
October 20, 2025 at 6:52 PM
(5/n) We think mitotic microcompartments are largely driven by entropy
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction
Going back to thermo, G = H - T*S
We typically think in terms of H (e.g. affinity), but S is equally important.
Prediction: all affinity-driven interactions (A/B-compartments, microcompartments) should be favored by compaction