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COVID Chronicles @covidchronicles.bsky.social · 2d

Ok. Allow me to circle back to your expertise (which I do value) when and if. You've given me food for thought.

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COVID Chronicles @covidchronicles.bsky.social · 2d

I agree. Removed.

COVID Chronicles @covidchronicles.bsky.social · 2d

Not looking to scare people. I am myself scared. It's been 1128 days since a mild infection sent me from running marathons to barely able to run errands. No one can tell me why or why me. So I've been seeing COVID through that lens. Exercising an excess of caution until we know more.

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COVID Chronicles @covidchronicles.bsky.social · 2d

I'm not a prof in immunology. I am well aware that studies are misinterpreted & that the journalistic class that should be breaking them down for us commoners have utterly failed at their jobs. I'm being earnest: if you have a page or resource that actually has a handle on COVID, I'd welcome it.

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COVID Chronicles @covidchronicles.bsky.social · 2d

So far you've blasted every link I've posted, offering none in return; used arguments from authority—a logical fallacy—dismissing findings in credible journals & putting the onus on me to defend them to you. You've clearly solved COVID. Too bad you're more interested in scolding than educating.

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COVID Chronicles @covidchronicles.bsky.social · 2d

Listen, I'm not looking to be right: I'm looking to be correct. If you can direct me to such studies, I'll gladly add them to my database. You're right that people seek to confirm their biases (myself included, being disabled from COVID). But I'm most interested in the truth.

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COVID Chronicles @covidchronicles.bsky.social · 2d

“We find that ex vivo isolated CD14+ monocytes from mild and moderate COVID-19 patients are phenotypically different from monocytes from healthy individuals” specifically reprogramming them to be “functionally pro-thrombotic” or prone to triggering blood clotting.

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 - Nature Communications

Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response and a pro-thrombotic signature following secondary SARS-CoV-2 challenge.

www.nature.com

COVID Chronicles @covidchronicles.bsky.social · 2d

“SARS-CoV-2 infected T helper cells express higher amounts of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may explain the poor adaptive immune response of many COVID-19 patients.”

SARS-CoV-2 uses CD4 to infect T helper lymphocytes

The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing immu...

doi.org

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COVID Chronicles @covidchronicles.bsky.social · 2d

“We observe a comparable reduction in B cells in both diseases and a more severe reduction in the total amount of T cells in COVID-19 as compared to AIDS patients”

(PDF) AIDS and COVID-19 are two diseases separated by a common lymphocytopenia

PDF | HIV and SARS-CoV-2 are responsible for two of the most dangerous and life-threatening infectious diseases of our times. To better analyze the... | Find, read and cite all the research you need o...

www.researchgate.net

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COVID Chronicles @covidchronicles.bsky.social · 2d

“COVID-19 is multiphasic in its pathogenesis, and includes a cytokine storm, lymphopenia and ARDS, which indicate poor prognosis. COVID-19 progression and severity are associated with a systemic dysregulation of the immune system and impaired type I IFN early responses.”

SARS-CoV-2 and HIV-1: So Different yet so Alike. Immune Response at the Cellular and Molecular Level

In the past half century, humanity has experienced two devastating pandemics; the HIV-1 pandemic and the recent pandemic caused by SARS-CoV-2. Both emerged as zoonotic pathogens. Interestingly, SARS-C...

www.ncbi.nlm.nih.gov

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COVID Chronicles @covidchronicles.bsky.social · 2d

“The relative risk of any autoimmune disease was 2.32 (95% confidence interval, 2.08–2.60). All the investigated outcomes showed a significant risk associated with COVID-19, and the long-term risk is substantial for systemic sclerosis and immunoglobulin G4–related disease.”

journals.lww.com

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COVID Chronicles @covidchronicles.bsky.social · 2d

“We found that SARS-CoV-2 infection causes immunodeficiency in recovered patients”

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

www.nature.com

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COVID Chronicles @covidchronicles.bsky.social · 2d

"Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection."

Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection

Mild to severe COVID-19, but not other respiratory infections, increased cellular senescence and exhaustion in CD4 and CD8 T cells over a 7-d period of inf

academic.oup.com

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COVID Chronicles @covidchronicles.bsky.social · 2d

A block would be unfortunate as we are not enemies. I'm sorry I was so abrasive. It was late and I get irate. That's on me. As for the google doc, it's not a conspiracy webpage: it's a list of vetted studies I co-curate (in an attempt to make sense of this plague). For easy access to key papers.

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COVID Chronicles @covidchronicles.bsky.social · 2d

The study's conclusions conveniently neglect pages upon pages of physiological proof of the damage SARS CoV-2 inflicts. Long COVID is not a binary condition—it's what we call it when the COVID-induced injuries are too severe to ignore.

Statistics and surveys are one thing. This is quite another:

COVID research & implications

Covid research & implications Purpose: This document is a running curation of Covid research cited in scholarly journals and/or trustworthy popular media, with the goal of forming a story about the i...

docs.google.com

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COVID Chronicles @covidchronicles.bsky.social · 2d

I hadn't read the study in question, just did. And am keen on digging further, as this would be good news indeed. But to claim that Omicron did not induce Long COVID as previous strains had flies in the face of many other metrics. Including yours truly's lived experience. Beware your own bias.

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COVID Chronicles @covidchronicles.bsky.social · 2d

Aïe aïe aïe, you're comparing SARS CoV-2 to "other pandemics", as if we didn't have piles of evidence on COVID's ability to evade and hijack immunity (leading to spikes in Strep A, Cancers, etc).

Pretty bold for someone deploring how experts make bold statements outside their fields of expertise…

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COVID Chronicles @covidchronicles.bsky.social · 2d

Interesting.

And dispiriting for those of us whose 1st and only infection was in late 2022, while fully vaccinated and boosted, & ended up with crippling PEM.

Your comments seem to suggest that no one is developing PCC anymore. Testimonies on r/covidlonghaulers suggest otherwise.

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COVID Chronicles @covidchronicles.bsky.social · 2d

That's not to say people aren't latching on to every bit of confirmation they find (even if published in predatory journals with hack methodology) or dismissing good research because of scientific illiteracy, but there is a LOT of noise for what little signal we find.

It's exhausting, TBH.

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COVID Chronicles @covidchronicles.bsky.social · 2d

Yes & no:

Big name specialists who pushed "vax and relax" when there was clear evidence of SARS CoV-2 evading & corrupting immunity (of even vaccinated hosts) did more damage to institutional trust than the loons did.

The amount of bad science—"peer reviewed!"—I come across is eye-watering.

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COVID Chronicles @covidchronicles.bsky.social · 2d

We desperately need to get people off that platform. It's killing us all. #COVID #Climate #Fascism #Disinformation

Spam and Scams Proliferate in Facebook’s Political Ads

www.nytimes.com

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COVID Chronicles @covidchronicles.bsky.social · 3d

Except it siphons money from research that has legitimate, actionable leads to investigate.

It's dishonest and has become all too common. Drums up big headlines based on little more than a hyped-up hypothesis (and poor data), then we never hear from them again. They still get paid. We get nowhere.

The Bully Pulpit 🇨🇦 @thebullypulpit.bsky.social · Jul 24

JUNK SCIENCE ALERT: "Long-COVID breakthrough at #Montreal hospital. Researchers at Sainte-Justine Hospital in Montreal say they've made a breakthrough discovery in #LongCOVID"

Only they haven't—Their study has MAJOR flaws & their findings? Likely due to sex differences and contraception use (!!!) ↓

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COVID Chronicles @covidchronicles.bsky.social · 3d

I suspect the purpose of the press release was to drum up more funding.

Methodology looks so suspect, the findings are little more than conjecture.

The Bully Pulpit 🇨🇦 @thebullypulpit.bsky.social · 3d

Bad science alert:

1) No sex & age matching;
2) ME cases were from the CureME biobank; controls came from the company’s own biobank;
3) All cases were severe, house-bound; all controls were healthy & likely physically active (vs having other chronic conditions—depression, fibromyalgia, MS…)

👎

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COVID Chronicles @covidchronicles.bsky.social · 3d

That, I suspect, was the purpose of the press release: to drum up more funding.

Methodology looks suspect, per Dr Alastair Miller, Chris Ponting (Chair of Medical Bioinformatics, University of Edinburgh) & Kevin McConway (Emeritus Professor of Applied Statistics, Open University)

The Bully Pulpit 🇨🇦 @thebullypulpit.bsky.social · 3d

Bad science alert:

1) No sex & age matching;
2) ME cases were from the CureME biobank; controls came from the company’s own biobank;
3) All cases were severe, house-bound; all controls were healthy & likely physically active (vs having other chronic conditions—depression, fibromyalgia, MS…)

👎

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Reposted by COVID Chronicles

The Bully Pulpit 🇨🇦 @thebullypulpit.bsky.social · 3d

Bad science alert:

1) No sex & age matching;
2) ME cases were from the CureME biobank; controls came from the company’s own biobank;
3) All cases were severe, house-bound; all controls were healthy & likely physically active (vs having other chronic conditions—depression, fibromyalgia, MS…)

👎

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