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Reposted by David Entenberg

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 8d

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

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Reposted by David Entenberg

Montefiore Einstein Pathology @monteeinsteinpath.bsky.social · Sep 3

Metastasis drives most #breastcancer deaths.
A new study led by Dr. Rachel Hazan of Einstein shows how the Wnt/ERK/CDK4/6 pathway fuels the growth of aggressive hybrid tumor cells. Blocking it slowed tumor growth and reduced aggressiveness.
In British J of Cancer tinyurl.com/5xpscst6
#metasasis

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David Entenberg @dentenberg.bsky.social · Aug 29

Great go see this finally come out! Exciting work! Congratulations!

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David Entenberg @dentenberg.bsky.social · Aug 5

Please join me in congratulating the newly minted Dr. Madeline Friedman DeLuca! She did a phenomenal job in her thesis defense today!

#ProudPI

@cdi-einstein.bsky.social @einsteinmededu.bsky.social @monteeinsteinpath.bsky.social

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David Entenberg @dentenberg.bsky.social · Mar 26

Was a really great talk!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Mar 25

Really excited to hear the presentation by Dr. Morad on microbiota, dormancy and brain metastasis @gmorad.bsky.social @cdi-einstein.bsky.social - Thanks for sharing your data with us!

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David Entenberg @dentenberg.bsky.social · Mar 26

Congratulations Neta! !מזל טוב

Metastasis Research Society @metastasisresearch.bsky.social · Mar 24

1/8 The Metastasis Research Society’s mission is to support progressive research on processes fundamental to metastasis and connect researchers, clinicians, industry, advocates and patients. Learn more about the vision and research of our next President @netaerez.bsky.social 🧵👇

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David Entenberg @dentenberg.bsky.social · Mar 20

Got to hear the amazing Miriam Merad talk today. Fantastic work she's doing understanding how to better target tumor associated macrophages!

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David Entenberg @dentenberg.bsky.social · Mar 15

WR-JSHS? I heard that they are trying to get it back for next year.

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David Entenberg @dentenberg.bsky.social · Mar 15

What a fantastic day of science! Those were amazing projects!

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David Entenberg @dentenberg.bsky.social · Mar 15

Super excited to hear all the great student research at #WESEF (the second largest science fair in the country).

My list, just 7 of the nearly 800 projects being presented today, shows how students are helping to fight sickle cell disease, lung cancer, and inflammatory bowel disease.

David Entenberg @dentenberg.bsky.social · Mar 1

Welcome!!!

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David Entenberg @dentenberg.bsky.social · Feb 17

Just finished reviewing grants for study section. Quick question for other reviewers. What do you read first when reviewing a grant? Coment on your favorite method and why.

1️⃣ Abstract/Narrative
2️⃣️ Specific Aims
3️⃣ Research Strategy
4️⃣ Biosketches
5️⃣ Straight through like a book

📊 Show results

David Entenberg @dentenberg.bsky.social · Feb 16

Oh my! So glad to see you're trying it out the protocol and fighting metastasis.

If you haven't, check out our JoVE video. We introduced a few new tools to make the surgery easier.

app.jove.com/v/62761/a-pe...

Good luck. Reach out if you have any questions! Looking forward to seeing your videos!

A Permanent Window for Investigating Cancer Metastasis to the Lung

Watch this Scientific Journal Video about A Permanent Window for Investigating Cancer Metastasis to the Lung at JoVE.com

app.jove.com

David Entenberg @dentenberg.bsky.social · Feb 14

So excited to share the latest work from the amazing Serena Lucotti and the rest of the David Lyden Lab out now in Cell.

Super honored to have been able to help out in this great work!

news.weill.cornell.edu/news/2025/02...

www.cell.com/cell/abstrac...

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David Entenberg @dentenberg.bsky.social · Feb 11

For your favorite AI... Worked well in Perplexity.

My zip code is XXXXX. Look up who my senators are and who my representative in the house is and write separate letters to them urging them to oppose the NIH cuts to indirect costs. Talk about how it will be damaging to science and to the country.

David Entenberg @dentenberg.bsky.social · Feb 11

Please write to your representatives in congress asking them to oppose the cuts in NIH funding. Whether you think that limiting overhead is good or bad, drastically cutting funding in such a short time span is destructive. If this stands, the negative impact on science will be felt for generations.

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Reposted by David Entenberg

Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Feb 1

New work from @cdi-einstein.bsky.social member @dentenberg.bsky.social showing how in certain conditions chemotherapy may enhance mechanisms of dissemination. Important work. www.biorxiv.org/content/10.1...

Paclitaxel causes de novo induction of invasive breast cancer cells by repolarizing tumor-associated macrophages

Background Metastasis is the leading cause of breast cancer (BC) death, and tumor cells must migrate and invade to metastasize. BC cells that express the pro-metastatic actin regulatory protein MenaIN...

www.biorxiv.org

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David Entenberg @dentenberg.bsky.social · Feb 1

Our findings point to another way in which tumor associated macrophages help cancer cells escape and spread. But our findings also suggest that microenvironment-based therapies, like blocking macrophage repolarization, may reduce the pro-metastatic side effects of NAC in breast cancer.

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David Entenberg @dentenberg.bsky.social · Feb 1

increase in macrophage-tumor cell NF-kB/ Notch1 signaling, which results in MenaINV induction. Blocking the Notch pathway during paclitaxel treatment stops this effect.

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David Entenberg @dentenberg.bsky.social · Feb 1

One way this happens is through the increase in MenaINV, a protein tumor cells use to get in and out of blood vessels in the breast and the lung. In this new work investigated what may cause this increase. We find that NAC causes a re-polarization of tumor-associated macrophages. This leads to an

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David Entenberg @dentenberg.bsky.social · Feb 1

Neoadjuvant chemotherapy (NAC) helps shrink tumors and extend the lives of many breast cancer patients. That is clear. However, a few years ago we and others discovered that in some cases, neoadjuvant paclitaxel may have an unwanted side effect where dissemination is inadvertently increased.

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David Entenberg @dentenberg.bsky.social · Feb 1

Super excited to share the latest work by the amazing Madeline DeLuca-Friedman, now out as a preprint on @BioRxiv!

What's it all about? Keep reading!

www.biorxiv.org/content/10.1...

@cdi-einstein.bsky.social
@einsteinmededu.bsky.social
@monteeinsteinpath.bsky.social

Paclitaxel causes de novo induction of invasive breast cancer cells by repolarizing tumor-associated macrophages

Background Metastasis is the leading cause of breast cancer (BC) death, and tumor cells must migrate and invade to metastasize. BC cells that express the pro-metastatic actin regulatory protein MenaIN...

www.biorxiv.org

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David Entenberg @dentenberg.bsky.social · Jan 5

Sounds like a great evening!

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David Entenberg @dentenberg.bsky.social · Jan 5

Seems like a modern day version of Night on Earth.

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David Entenberg @dentenberg.bsky.social · Jan 5

Haven't seen it yet, but it's on my list!

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