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Reposted by Aguirre-Ghiso Lab

soledadsosalab.bsky.social @soledadsosalab.bsky.social · 11h

@susangkomen.bsky.social It is a profound honor to accept the Susan G. Komen Next Generation Researcher Award. Thanks for making me feel part of
this community and our shared fight against cancer. Thanks to my lab members, my family and my husband for making this possible. @cdi-einstein.bsky.social

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 3h

So proud of you !! A hugely deserved recognition of your past work and future vision. Congratulations!!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 1d

On Tuesday I had a great day of science and discussions visiting @danafarber.bsky.social & delivering the Harriet Tischler Memorial Lecture - thanks again Kornelia Polyak for a great day & for the stellar company during dinner with the amazing Joan Brugge and Alex Toker. @cdi-einstein.bsky.social

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 4d

Super honored to be visiting @danafarber.bsky.social to deliver the 2025 Harriet Tischler Memorial Lecture hosted by the amazing Nelly Polyak. Thanks for the invitation!
seminarsinoncology.dana-farber.org

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Reposted by Aguirre-Ghiso Lab

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 7d

Amazing work from investigators at the @cdi-einstein.bsky.social. Congrats @divijverma.bsky.social and team! Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion url: aacrjournals.org/cancerdiscov...

Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion

Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of f...

aacrjournals.org

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 7d

Amazing work from investigators at the @cdi-einstein.bsky.social. Congrats @divijverma.bsky.social and team! Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion url: aacrjournals.org/cancerdiscov...

Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion

Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of f...

aacrjournals.org

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 7d

The benefits of Tango dancing www.nature.com/articles/d41...

Creative hobbies could slow brain ageing at the molecular level

To keep the mind young, dance the tango.

www.nature.com

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 8d

Great @cdi-einstein.bsky.social seminar by Jose Javier Bravo Cordero from @mountsinainyc.bsky.social covering ECM architecture, metabolism and neuroscience. Fantastic work! Thanks for visiting us!

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 9d

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 9d

oncodaily.com/voices/metas.... Thanks for sharing this post with a broader audience @oncodaily.bsky.social the goal of our @cdi-einstein.bsky.social is to bring new science for interception of metasasis / recurrence and MRD at its earliest point.

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality - OncoDaily

Julio Aguirre-Ghiso: Metastasis and the Real Causes of Cancer Mortality / Adrienne Boire, Alexander Yang, Allison W. Kurian, Amy B. Knudsen, Amy

oncodaily.com

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

Management of metastasis-related lethality should expand from metastasis/recurrence treatment to metastasis prevention (earlier interception/treatments) and learn from the experience in cancer prevention. pubmed.ncbi.nlm.nih.gov/39636625/ A new mindset and technology expansion is needed for this.

Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020 - PubMed

Over the past 45 years, cancer prevention and screening accounted for most cancer deaths averted for these causes; however, their contribution varied by cancer site according to these models using pop...

pubmed.ncbi.nlm.nih.gov

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

But acting early is key. Managing late-stage metastatic symptoms is necessary but will likely offer only marginal survival gains. Treatments moved from stage IV to the adjuvant phase have revolutionized outcomes (Trastuzumab, Pembrolizumab, Osimertinib & combinations like Dabrafenib & Trametinib)

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

These data lead to the question, what do we need to focus on to change survival? Targeting metastasis early before they start to cause all the problems mentioned above or intervene the actual consequences of metastasis. Maybe both?

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

In patient with bone metastasis across all cancers, death unrelated to metastasis was 5.9%. www.sciencedirect.com/science/arti... So majority of deaths are cancer metastasis linked.

Comprehensive analysis of cancer and non-cancer mortality in patients with bone metastases: A population-based study

To characterize causes of death in patients with bone metastases and to support data-driven approaches to survivorship planning and clinical decision-…

www.sciencedirect.com

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

One could also ask: how many patients that have metastasis die due to causes not related to metastasis? In a large US registry-based study 82.6% of patients with metastatic cancer die from cancer, while 17.4% die from non-cancer causes pmc.ncbi.nlm.nih.gov/articles/PMC...

Causes of death among people living with metastatic cancer

Studying survivorship and causes of death in patients with advanced or metastatic cancer remains an important task. We characterize the causes of death among patients with metastatic cancer, across 13...

pmc.ncbi.nlm.nih.gov

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

What is the actual source of metastatic lethality? Organ failure, obstruction (directly by metastasis), cachexia, bleeding, infection, paraneoplastic syndromes and are considered "cancer (metastasis)-specific" causes of death. In melanoma these have been measured ascopubs.org/doi/10.1200/....

Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era.

e21522Background: Despite the drastic improvement in survival of patients with metastatic melanoma from immune checkpoint inhibitors (ICIs), almost half of patients still die from their disease. Facto...

ascopubs.org

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

Then people ask, do the metastases directly kill the patient, or is it a bystander effect of the metastasis? The answer has been expertly covered by pmc.ncbi.nlm.nih.gov/articles/PMC...

Roadmap: Why do patients with cancer die?

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. A large number of patients with cancer experience reduced life expectancy and have metas...

pmc.ncbi.nlm.nih.gov

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.frontiersin.org/journals/end...
The answer is that, yes, majority of the deaths are metastasis-linked.

Are 90% of deaths from cancer caused by metastases?

Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of canc...

pmc.ncbi.nlm.nih.gov

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 12d

Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 13d

Delighted to host Dr. Javier Bravo Cordero at our Cancer Dormancy Institute Seminar Series. Don't miss his exceptional work! @cdi-einstein.bsky.social @einsteinmededu.bsky.social @einsteincellbio.bsky.social

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 14d

I could not stay the entire meeting but it was great seeing friends and colleagues Evi Lianidou, Angela Nieto AndreasTrumpp Caroline Dive and many more at the 7th ACTC Meeting in Thessaloniki, Greece. Great to bring the science we are developing @cdi-einstein.bsky.social to this meeting.

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 16d

Delighted to have opened this fantastic meeting in beautiful Thessaloniki organized by the equally amazing Evi Lianidou presenting updates from the lab @cdi-einstein.bsky.social including our CH collaborative work with @rosslevinemd.bsky.social lab.

www.erasmus.gr/microsites/1...

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 21d

Excited about a day of exceptional cancer science being developed at our @einsteinmededu.bsky.social comprehensive cancer center. Featuring science being developed at our Cancer Dormancy Institute @cdi-einstein.bsky.social - proud to be part of this amazing community

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Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 23d

Happy to give the fist talk at this amazing symposium on our work with @rosslevinemd.bsky.social - thanks to @themarkfdn.bsky.social and the Samuel Waxman Cancer Research Foundation for their support ! Thanks to @jacksonlab.bsky.social for hosting and teaming on this symposium.

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 26d

Wonderful afternoon of games and good food with the lab last week celebrating our strong team.